An electronic device equipped with sensors and antennas is the main part of the wireless body area networking (WBAN). Such a device is placed near human body and it usually works in a populated environment with many surrounding objects (e.g., building walls). The human body and the objects can change the radiation characteristics of the antenna and impact the performance of the wireless communication system. The wireless communication system's performance is also affected by the networking layers established on top of the physical layer. Therefore, any designing method for WBAN application should be pervasive, offering a joint physical-networking layer simulation and modeling strategy. To this end, in this chapter, a comprehensive simulation and modeling method is presented. First, antenna design limitations and challenges for wireless body area networking are studied with emphasis on evaluating the antenna's performance near the human body. Then, the antenna miniaturization techniques to reduce the antennas' dimension are reviewed. Later, a system level analysis and modeling are used to study short-range communication between the wearable antennas with remote nodes using IEEE 802.11g wireless networking protocol.