Performance of fourier domain vs time domain optical coherence tomography

Leitgeb, Rainer A.; Hitzenberger, Christoph K.; Fercher, Adolf Friedrich

doi:10.1364/oe.11.000889

Cited by 1,739 publications

(1,127 citation statements)

References 8 publications

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“…The instrument is a high-speed UHR OCT system using spectral/Fourier domain detection. [34][35][36] Spectral/Fourier domain detection operates by first measuring the interference spectrum between backscattered or backreflected light from the tissue and light from a stationary reference arm. The magnitude and echo time delay of the light signal from the tissue is measured by taking the Fourier transform of this interference spectrum.…”

Section: Methodsmentioning

confidence: 99%

“…Broad-bandwidth superluminescent diode light sources, similar to the one used in this study, recently have been shown to enable UHR OCT image resolution performance approaching that of femtosecond lasers. [27][28][29][30][31][32][33][34][35][36][37][38] Our research prototype high-speed UHR OCT system has been described in detail in previous publications. [29][30][31][32][33] This system can acquire up to 25 000 axial scans per second, corresponding to ~49 images (512 axial scans per image) per second.…”

Section: Methodsmentioning

confidence: 99%

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High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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Objective-To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design-Retrospective cross-sectional study.Participants-Five hundred eighty-eight eyes of 327 patients with various macular pathologies.Methods-High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ~3-μm axial image resolutions, acquisition speeds of ~25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures-High-definition macular pathologies.Results-Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density Conclusions-High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.Optical coherence tomography (OCT) is a medical imaging technology that can perform highresolution cross-sectional imaging of tissue morphology in situ and in real time. Optical coherence tomography imaging is analogous to ultrasound, except that it uses light rather than sound and measures the echo time delay and magnitude of reflected or backscattered light using low-coherence interferometry. Cross-sectional images are generated by directing an optical beam onto tissue and scanning it in the transverse direction, thus yielding a data set that can be displayed as false-color or grayscale images. Despite the successful clinical application of OCT technology, there are several limitations. Without using techniques such as eye tracking, the total permissible image acquisition time is limited by subject eye motion, which can cause imag...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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“…Optical coherence tomography (OCT) is a non invasive and cross sectional imaging technique that permits, for example, three dimensional images of micrometre resolution to be obtained from within the retina [1,2]. Historically, OCT systems were developed and optimized for medical applications.…”

Section: Introductionmentioning

confidence: 99%

Enhanced optical coherence vibration tomography for subnanoscale-displacement-resolution calibration of piezoelectric actuators

Zhong

Zhang

2015

Sensors and Actuators A: Physical

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We report a subnanoscale displacement resolution optical coherence vibration tomography (SOCVT) system for real time calibration of piezoelectric actuators. The calibrations of the actuators at nanoscale or microscale displacement ranges were performed by varying the input voltage over the entire range in the ascending and descending directions. The computational and experimental results demonstrated that the developed SOCVT could be used to characterize the dynamic hysteretic behaviour, nonlinear effect, and impulsive behaviour of piezoelectric actuators. The SOCVT technique is non contact and non invasive in nature, making it ideal for real time and in situ ultra precision calibration of piezoelectric actuators, which are widely used in active vibration control and nanopositioning.

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“…6,[14][15][16][17][18][19][20] Compared with conventional time domain OCT, Fourier domain OCT (FD-OCT) offers significant advantages in imaging speed and sensitivity. 21,22 There are two primary types of FD-OCT implementations, depending on the light source and detector configuration. One is the spectral domain OCT (SD-OCT) with a spectrometer and a line-scan charge-coupled device (CCD).…”

Section: Introductionmentioning

confidence: 99%

Extended scan depth optical coherence tomography for evaluating ocular surface shape

Shen

Cui

et al. 2011

J. Biomed. Opt.

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Abstract. Spectral domain optical coherence tomography (SD-OCT) with extended scan depth makes it possible for quantitative measurement of the entire ocular surface shape. We proposed a novel method for ocular surface shape measurement using a custom-built anterior segment SD-OCT, which will serve on the contact lens fitting. A crosshair alignment system was applied to reduce the misalignment and tilting of the eye. An algorithm was developed to automatically segment the ocular surface. We also described the correction of the image distortion from the segmented dataset induced by the nontelecentric scanning system and tested the accuracy and repeatability. The results showed high accuracy of SD-OCT in measuring a bicurved test surface with a maximum height error of 17.4 μm. The repeatability of in vivo measurement was also good. The standard deviations of the height measurement within a 14-mm wide range were all less than 35 μm. This work demonstrates the feasibility of using extended depth SD-OCT to perform noninvasive evaluation of the ocular surface shape. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Performance of fourier domain vs time domain optical coherence tomography

Cited by 1,739 publications

References 8 publications

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

Enhanced optical coherence vibration tomography for subnanoscale-displacement-resolution calibration of piezoelectric actuators

Extended scan depth optical coherence tomography for evaluating ocular surface shape

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