Performance of hydroxyapatite bone repair scaffolds created via three‐dimensional fabrication techniques

Roy, T. Dutta; Simon, Jean-Pierre; Ricci, John L.; Rekow, E. Dianne; Thompson, Van P.; Parsons, J. R.

doi:10.1002/jbm.a.20034

Cited by 113 publications

(37 citation statements)

References 31 publications

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“…Biodegradable and bioresorbable polymeric and composite scaffolds with defined internal structures have been manufactured directly as well as indirectly using stereolithography (SLA),3 fused deposition modeling,4 3D plotting,5, 6 and 3D printing 7–10. Ceramic scaffolds for bone replacement have been produced using laminated object manufacturing,11 selective laser sintering,12 SLA,13 and 3D printing 14. Furthermore, wax molds generated by the ModelMaker II RP system (Solidscape Inc., USA) were also used to fabricate ceramic15 and composite scaffolds 16…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional printing of porous ceramic scaffolds for bone tissue engineering

et al. 2005

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This article reports a new process chain for custom-made three-dimensional (3D) porous ceramic scaffolds for bone replacement with fully interconnected channel network for the repair of osseous defects from trauma or disease. Rapid prototyping and especially 3D printing is well suited to generate complex-shaped porous ceramic matrices directly from powder materials. Anatomical information obtained from a patient can be used to design the implant for a target defect. In the 3D printing technique, a box filled with ceramic powder is printed with a polymer-based binder solution layer by layer. Powder is bonded in wetted regions. Unglued powder can be removed and a ceramic green body remains. We use a modified hydroxyapatite (HA) powder for the fabrication of 3D printed scaffolds due to the safety of HA as biocompatible implantable material and efficacy for bone regeneration. The printed ceramic green bodies are consolidated at a temperature of 1250 degrees C in a high temperature furnace in ambient air. The polymeric binder is pyrolysed during sintering. The resulting scaffolds can be used in tissue engineering of bone implants using patient-derived cells that are seeded onto the scaffolds. This article describes the process chain, beginning from data preparation to 3D printing tests and finally sintering of the scaffold. Prototypes were successfully manufactured and characterized. It was demonstrated that it is possible to manufacture parts with inner channels with a dimension down to 450 microm and wall structures with a thickness down to 330 microm. The mechanical strength of dense test parts is up to 22 MPa.

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Section: Introductionmentioning

confidence: 99%

Three‐dimensional printing of porous ceramic scaffolds for bone tissue engineering

et al. 2005

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“…Some studies demonstrated that cell distribution within the TEBG directly influenced and even decided the distribution and growth pattern of bone regeneration [44], [45]. Well-defined 3D scaffold loaded with homogeneous osteoblasts and extracellular matrix promote discontinuous ingrowth with separated bone islands throughout the whole scaffold.…”

Section: Discussionmentioning

confidence: 99%

Repair of Segmental Bone Defect Using Totally Vitalized Tissue Engineered Bone Graft by a Combined Perfusion Seeding and Culture System

Wang

Zhang

et al. 2014

PLoS ONE

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BackgroundThe basic strategy to construct tissue engineered bone graft (TEBG) is to combine osteoblastic cells with three dimensional (3D) scaffold. Based on this strategy, we proposed the “Totally Vitalized TEBG” (TV-TEBG) which was characterized by abundant and homogenously distributed cells with enhanced cell proliferation and differentiation and further investigated its biological performance in repairing segmental bone defect.MethodsIn this study, we constructed the TV-TEBG with the combination of customized flow perfusion seeding/culture system and β-tricalcium phosphate (β-TCP) scaffold fabricated by Rapid Prototyping (RP) technique. We systemically compared three kinds of TEBG constructed by perfusion seeding and perfusion culture (PSPC) method, static seeding and perfusion culture (SSPC) method, and static seeding and static culture (SSSC) method for their in vitro performance and bone defect healing efficacy with a rabbit model.ResultsOur study has demonstrated that TEBG constructed by PSPC method exhibited better biological properties with higher daily D-glucose consumption, increased cell proliferation and differentiation, and better cell distribution, indicating the successful construction of TV-TEBG. After implanted into rabbit radius defects for 12 weeks, PSPC group exerted higher X-ray score close to autograft, much greater mechanical property evidenced by the biomechanical testing and significantly higher new bone formation as shown by histological analysis compared with the other two groups, and eventually obtained favorable healing efficacy of the segmental bone defect that was the closest to autograft transplantation.ConclusionThis study demonstrated the feasibility of TV-TEBG construction with combination of perfusion seeding, perfusion culture and RP technique which exerted excellent biological properties. The application of TV-TEBG may become a preferred candidate for segmental bone defect repair in orthopedic and maxillofacial fields.

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“…This enables control over various properties, such as thermal and electrical conductivity, hardness, magnetic properties, etc. It is very difficult to make fibre-reinforced composite using a powder-fibre mixture or jetting the fibre, but it is possible to infiltrate a porous preform of ceramics or metal obtained by 3DP with a metal or alloy to make the composite [12][13][14].…”

Section: Three-dimensional Printing (3dp)mentioning

confidence: 99%

Rapid Prototyping: Technologies, Materials and Advances

Dudek¹,

Rapacz-Kmita²

2016

Archives of Metallurgy and Materials

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In the context of product development, the term rapid prototyping (RP) is widely used to describe technologies which create physical prototypes directly from digital data. Recently, this technology has become one of the fastest-growing methods of manufacturing parts. The paper provides brief notes on the creation of composites using RP methods, such as stereolithography, selective laser sintering or melting, laminated object modelling, fused deposition modelling or three-dimensional printing. The emphasis of this work is on the methodology of composite fabrication and the variety of materials used in these technologies.

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Performance of hydroxyapatite bone repair scaffolds created via three‐dimensional fabrication techniques

Cited by 113 publications

References 31 publications

Three‐dimensional printing of porous ceramic scaffolds for bone tissue engineering

Three‐dimensional printing of porous ceramic scaffolds for bone tissue engineering

Repair of Segmental Bone Defect Using Totally Vitalized Tissue Engineered Bone Graft by a Combined Perfusion Seeding and Culture System

Rapid Prototyping: Technologies, Materials and Advances

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