Performance of magnetic chitosan–alginate core–shell beads for increasing the bioavailability of a low permeable drug

Seth, Anjali; Lafargue, David; Poirier, Cécile; Péan, Jean-Manuel; Ménager, Christine

doi:10.1016/j.ejpb.2014.05.017

Cited by 22 publications

(13 citation statements)

References 34 publications

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“…Once non-haem iron is inside the enterocyte, it can be either stored as ferritin or exported through the basolateral membrane from the ferrous iron pool to blood stream by the combined action of ferroportin (FPN) and hephaestin. [ [7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, IONP are employed as suitable platforms for biosensing [2], biomolecular-magnetic trapping [5], magnetic hyperthermia [6], imaging [7], drug-or gene-delivery [8][9]. There is a wide variety of IONP preparation methods providing controllable nanoparticle size and customized physical, chemical and biological functionalities without cytotoxicity drawbacks [4,[10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…The assessment of IONP toxicity, biodistribution and excretion routes after long-term exposure is mandatory prior to a safe incorporation into clinical practice. Little attention has been paid to the effects related to IONP oral exposure in spite of the use of engineered nanoparticles for nutritional [19][20][21][22][23] and pharmaceutical [8,[24][25] purposes is expected to increase [20,[26][27]]. An important issue is related to the oral administration of nanoparticles where magnetic ones offer the possibility to magnetically guide the drug delivery to intentionally enhance the drug release into the affected tissue [8].…”

Section: Introductionmentioning

confidence: 99%

“…Little attention has been paid to the effects related to IONP oral exposure in spite of the use of engineered nanoparticles for nutritional [19][20][21][22][23] and pharmaceutical [8,[24][25] purposes is expected to increase [20,[26][27]]. An important issue is related to the oral administration of nanoparticles where magnetic ones offer the possibility to magnetically guide the drug delivery to intentionally enhance the drug release into the affected tissue [8]. There exist toxicity and gastro-intestinal functioning concerns related to the oral exposure to IONP, especially regarding the absorption of metals like iron [20,[28][29].…”

Section: Introductionmentioning

confidence: 99%

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Safety assessment of chronic oral exposure to iron oxide nanoparticles

et al. 2015

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Iron oxide nanoparticles with engineered physical and biochemical properties are finding a rapidly increasing number of biomedical applications. However, a wide variety of safety concerns, especially those related to oral exposure, still needs to be addressed in order to reach the clinical practice. Here, we report on the effects of chronic oral exposure to low dose 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 reveal that oral administration of iron oxide nanoparticles is a safe route for drug delivery at low nanoparticle doses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety assessment of chronic oral exposure to iron oxide nanoparticles

et al. 2015

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“…Fluorescent and magnetic chitosan alginate core-shell beads containing the drug were prepared as previously described using a standard extrusion crosslinking method (Seth et al, 2014…”

Section: Fluorescent and Magnetic Chitosan-alginate Core-shell Beamentioning

confidence: 99%

Optimization of magnetic retention in the gastrointestinal tract: Enhanced bioavailability of poorly permeable drug

Seth

Lafargue

Poirier

et al. 2017

European Journal of Pharmaceutical Sciences

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Oral administration of low permeable drugs remains a challenge as they do not cross biological membrane efficiently and therefore exhibit a poor bioavailability. Herein, the effect of magnetic retention on the circulation and bioavailability of magnetic beads in the gastrointestinal tract in the presence of an external magnetic field is evaluated. Retention efficiency is imaged using magnetic resonance and near infrared techniques. The effect on bioavailability is then evaluated in a pharmacokinetic study. Iron oxide nanoparticles, the drug (dipeptidyl peptidase-IV inhibitor) and a fluorophore (Alexa Fluor-750) are co-encapsulated in chitosan-alginate core-shell beads. Retention of these beads is induced by the presence of an external permanent magnet on the abdomen of rats. After single administration of magnetic beads containing 20mg/kg of drug to fasted rats, a 2.5-fold increase in drug's bioavailability is observed in the presence of an external magnetic field, significantly higher than the same dose administered to rats without the field or for the drug in aqueous solution. Retention of the magnetic carriers in the presence of an external magnet proves to accumulate these carriers in a specific localization of the intestine leading to a significant improve in the drug's bioavailability.

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