“…In India, E. coli isolated from the Ganga river showed resistance to antibiotics cephalosporin (37%), ampicillin (20%), amoxicillin (20%), tetracycline (20%), and ciprofloxacin (5.30%) ( Biswas et al, 2015 ). Similarly, several studies had reported the presence of antibiotic-resistant E. coli in different environmental and clinical samples ( Sayah et al, 2005 ; Ram et al, 2007 , 2008 ; Li et al, 2010 ; Tagoe et al, 2011 ; Guo et al, 2014 , 2017 ; Adzitey et al, 2015 ; Chen et al, 2017 ; Muringani, 2017 ; Amer et al, 2018 ; Diwan et al, 2018 ; Igwaran et al, 2018 ; Lu et al, 2018 ; Mishra et al, 2018 ; Mitali et al, 2018 ; Vital et al, 2018 ; Amador et al, 2019 ; Sandhu et al, 2019 ). Study on distribution of ARGs in the present study reflects that the spring water of Sikkim are reservoirs of multiple ARGs.…”