Performance of noninvasive laser Doppler flowmetry and laser speckle contrast imaging methods in diagnosis of Buerger disease

You

et al. 2022

Sci Rep

The purpose of this study is to evaluate whether monitoring the changes of skin blood flow may be effective in assessing blood perfusion during endoscopic lumbar sympathectomy (ELS) in patients with plantar hyperhidrosis. In this study, a total of 30 patients who underwent surgical treatment for plantar hyperhidrosis at the Department of Thoracic and Cardiovascular Surgery in Yonsei University Gangnam Severance Hospital, Seoul, Korea, between July 2020 and December 2020, were retrospectively analyzed. Sympathetic denervation was performed on the third lumbar ganglion, and intraoperative laser doppler flowmetry (LDF) was used to detect the lumbar sympathetic chain accurately. We observed an abrupt increase of peripheral blood flow after sympathetic denervation, and the median percent changes of perfusion unit were 173.27 (inter-quartile range, IQR 195.48) and 392.98 (IQR 597.27) for the left and right sympathectomies, respectively. This study demonstrated the efficacy of monitoring skin blood flow via LDF during ELS. This result suggests that exact detection of blood flow using LDF is essential for improving the accuracy of ELS by checking the perfusion site on the sole in patients with plantar hyperhidrosis.

Section: Discussionmentioning

confidence: 97%

Evaluation of blood perfusion using laser doppler flowmetry during endoscopic lumbar sympathectomy in patients with plantar hyperhidrosis: a retrospective observational study

You

et al. 2022

Sci Rep

“…Moreover, increased perfusion units measured by LDF can re ect a digital vasodilatory response as the therapeutic effects of systemic sclerosis with Raynaud's phenomenon after nitroglycerin patch treatment 20 , and LDF can be used for objectively categorizing both the extent of microvascular circulatory impairment and treatment outcome in patients with thromboangiitis obliterans, known as Buerger's disease 21 . This suggests that we can consider the increased perfusion of the plantar region observed by LDF during ELS as potential evidence that ELS may be effective in treating peripheral vascular diseases, such as SSc and TAO [20][21][22] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Blood Perfusion Using Laser Doppler Flowmetry During Endoscopic Lumbar Sympathectomy in Patients with Plantar Hyperhidrosis: A Retrospective Observational Study

You

et al. 2022

Preprint

Background The purpose of this study is to evaluate whether monitoring the changes of skin blood flow may be effective in assessing blood perfusion during endoscopic lumbar sympathectomy (ELS) in patients with plantar hyperhidrosis. Methods In this study, a total of 30 patients who underwent surgical treatment for plantar hyperhidrosis at the Department of Thoracic and Cardiovascular Surgery in Yonsei University Gangnam Severance Hospital, Seoul, Korea, between July 2020 and December 2020, were retrospectively analyzed. Sympathetic denervation was performed on the third lumbar ganglion, and intraoperative laser doppler flowmetry (LDF) was used to detect the lumbar sympathetic chain accurately. Results We observed an abrupt increase of peripheral blood flow after sympathetic denervation, and the median percent changes of perfusion unit were 173.27 (inter-quartile range, IQR 195.48) and 392.98 (IQR 597.27) for the left and right sympathectomies, respectively. Conclusions This study demonstrated the efficacy of monitoring skin blood flow via LDF during ELS. This result suggests that exact detection of blood flow using LDF is essential for improving the accuracy of ELS by checking the perfusion site on the sole in patients with plantar hyperhidrosis.

Mìžnarodnij endokrinologìčnij žurnal

“…1). Цей шар може містити, залежно від типу тканини, такі ланки мікроциркуляторного русла: артеріоли, термінальні артеріоли, капіляри, посткапілярні венули, венули та артеріоловенулярні анастомози [26].…”

Section: результати та обговоренняunclassified

Prospects for the use of laser Doppler flowmetry to assess cutaneous blood microcirculation in diabetes mellitus

Шаєнко

Лігоненко

2022

The аrticle considers the scientific and clinical aspects of laser Doppler flowmetry (LDF) in the diagnosis of the state of the microcirculatory bed in diabetes mellitus. LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocation tests, which provides a study of the state of regulatory mechanisms of microcirculation. The difficulties with studying the microcirculation are caused by the very small size of microvessels. The prevention and treatment of various microcirculatory disorders is one of the most important problems in medical practice. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes mellitus. The use of LDF in scientific researches will make it possible to reveal changes in microcirculatory bed functioning that are characteristic of diabetes mellitus. The possibility of non-invasive quantitative assessment of the state of microcirculatory blood flow in real time and the relative ease of use explains the high popularity of LDF in scientific researches and makes this method promising for use in clinical practice. This method can be of important diagnostic value for the study of the state of different levels of regulation of the microcirculatory tract and dynamic monitoring of the effectiveness of the prescribed treatment. Combined use of LDF to identify the risk of developing diabetic foot syndrome will allow to personify the treatment of diabetes. Among the most promising points of application should be noted the study of microcirculation in the early diagnosis of diabetes and its complications, clarifying the risk of complications, monitoring the effectiveness of treatment. The development of optimal evaluation methods of microcirculation is a prospect for further research.