Performance of peripheral (serum and molecular) blood markers for diagnosis of endometriosis

Abstract

A combination of serum and molecular markers could allow a better diagnosis of endometriosis.

Survivin and Vegf as Novel Biomarkers in Diagnosis of Endometriosis/ Survivin i vegf kao novi biomarkeri u dijagnostici endometrioze

“…CA125 is a valuable marker in the diagnosis of endometriosis. Previous studies showed significantly higher levels of CA125 in the serum of patients with endometriosis (9, 10). Our results also revealed that the serum level of CA125 was significantly increased in patients with endometriosis.…”

Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

“…In spite of affecting 5 to 10% of women in reproductive age, the exact etiology of the disease remains an intriguing enigma, since it is currently accepted that multiple factors are involved in the pathogenesis of endometriosis [2][3][4][5][6][7][8]. In addition to an invasive phenotype of endometrial cells, neoangiogenesis and sustained local inflammatory response are believed to be crucial points in the pathophysiology of endometriosis [9][10][11][12][13][14][15]. Neoangiogenesis is evident by the visualization of peripheral vascularization of ectopic endometriotic tissue at laparoscopy and increased angiogenic activity and vascular endothelial growth factor (VEGF) levels found in peritoneal fluid of patients with endometriosis [3,11,12,[16][17][18].…”

Diagnostic value of serum tumor markers evaluation for adnexal masses

“…Literature data show that combined multiple tumor markers, such as serum Ca 125, Ca 19.9 and mRNA for Survivin gene, can improve the overall diagnostic accuracy of all stages of primary ovarian epithelial tumors and allow a better triage between endometriosis and malignant adnexal masses [7,24,25]. Up until now, different risk models and screening algorithms that combine and evaluate tumor markers together, aimed at improving the specificity and sensitivity of diagnostic tests, and allowing for an effective triage of women to appropriate institutions for their care, have been developed so far.…”