2020
DOI: 10.1093/alcalc/agaa027
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Performance of PEth Compared With Other Alcohol Biomarkers in Subjects Presenting For Occupational and Pre-Employment Medical Examination

Abstract: Abstract Aims To compare the performance of short- and long-term alcohol biomarkers for the evaluation of alcohol drinking in employment-related health controls. Methods The 519 blood samples originated from 509 patients (80% men) presenting at occupational health… Show more

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Cited by 28 publications
(31 citation statements)
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“…This study verifies the higher detection capability of PEth as a biomarker for alcohol consumption compared with CDT, as concluded in previous studies (Andresen‐Streichert et al, 2018; Helander et al, 2019a; Helander et al, 2012; Neumann et al, 2020; Winkler et al, 2013). A high number of subjects showed elevated PEth but not CDT levels.…”
Section: Discussionsupporting
confidence: 90%
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“…This study verifies the higher detection capability of PEth as a biomarker for alcohol consumption compared with CDT, as concluded in previous studies (Andresen‐Streichert et al, 2018; Helander et al, 2019a; Helander et al, 2012; Neumann et al, 2020; Winkler et al, 2013). A high number of subjects showed elevated PEth but not CDT levels.…”
Section: Discussionsupporting
confidence: 90%
“…The possibility of ultra‐rapid PEth metabolizers has been demonstrated in some individuals in previous research (Schröck et al, 2017a). Neumann and colleagues argue that 12 cases of low PEth, but positive CDT in their recent study possibly could be explained by relatively low PEth formation in some individuals (Neumann et al, 2020). In these cases, PEth must be considered a false negative result.…”
Section: Discussionmentioning
confidence: 93%
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“…Phosphatidylethanol (PEth), an ethanol (EtOH) biomarker, has been frequently used and characterized in the context of groups of individuals who consume unhealthy amounts of alcohol such as those attending alcohol treatment facilities and human immunodeficiency virus (HIV) clinics. There is increasing knowledge regarding the utility of PEth in the context of community‐dwelling adults (Helander et al, 2019; Neumann et al, 2020; Nguyen et al, 2018; Reisfield et al, 2020; Schrock et al, 2017; Ulwelling and Smith, 2018). However, less is known for older adults for whom alcohol consumption can have a different, often more detrimental, impact on health (Moos et al, 2005).…”
mentioning
confidence: 99%
“…Breath testing, which is used to estimate recent alcohol consumption from the blood alcohol concentration (BAC) at the moment of sampling, or other blood‐based measures such as ethyl glucuronide and ethyl sulfate can detect very recent alcohol ingestion (Halter et al, 2008; Mastrovito and Strathmann, 2020; Neumann et al, 2020; Reisfield et al, 2020). Other common blood‐ and urine‐based measures used in a clinical setting include carbohydrate‐deficient transferrin (CDT) and serum γ‐glutamyltransferase (GGT; Litten et al, 2010; Mastrovito and Strathmann, 2020; Neumann et al, 2020; Reisfield et al, 2020). However, CDT and GGT may be influenced by other factors besides alcohol intake, including smoking, gender, age, and various diseases (Andresen‐Streichert et al, 2018; Conigrave et al, 2003; Neumann et al, 2020).…”
mentioning
confidence: 99%