Performance of planar multisite microprobes in recording extracellular single-unit intracortical activity

Drake, Kenneth L.; Wise, K.D.; Farraye, Jamille; Anderson, David J.; BeMent, Spencer L.

doi:10.1109/10.7273

Cited by 332 publications

(195 citation statements)

References 11 publications

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“…Many types of microelectrode arrays have been developed, including microwires ( Nicolelis et al 1999;Williams et al 1999;Kralik et al 2001), silicon micromachined microprobes (SMMs; Drake et al 1988;Campbell et al 1991;Jones et al 1992;Hetke & Anderson 2002;Kipke et al 2003;Ludwig et al 2006) and polymer substrate probes (Rousche et al 2001;Schneider & Stieglitz 2004). Microwires and SMMs receive the most attention because they are easy to process and fabricate.…”

Section: Multiple Recording Electrode Typesmentioning

confidence: 99%

Biomaterials for the central nervous system

Zhong

Bellamkonda

2008

J. R. Soc. Interface.

218

163

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Biomaterials are widely used to help treat neurological disorders and/or improve functional recovery in the central nervous system (CNS). This article reviews the application of biomaterials in (i) shunting systems for hydrocephalus, (ii) cortical neural prosthetics, (iii) drug delivery in the CNS, (iv) hydrogel scaffolds for CNS repair, and (v) neural stem cell encapsulation for neurotrauma. The biological and material requirements for the biomaterials in these applications are discussed. The difficulties that the biomaterials might face in each application and the possible solutions are also reviewed in this article.

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Section: Multiple Recording Electrode Typesmentioning

confidence: 99%

Biomaterials for the central nervous system

Zhong

Bellamkonda

2008

J. R. Soc. Interface.

218

163

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“…Using hydraulic manipulators, silicon-substrate Michigan probes with 16 sputter-deposited iridium sites (Center for Neural Communication Technology, University of Michigan, Ann Arbor, MI) (Anderson et al 1989;Drake et al 1988;Najafi et al 1985) were inserted into the ICC and A1 (Fig. 1).…”

Section: Anesthesia and Surgerymentioning

confidence: 99%

Antidromic Activation Reveals Tonotopically Organized Projections From Primary Auditory Cortex to the Central Nucleus of the Inferior Colliculus in Guinea Pig

Lim¹,

Anderson²

2007

Journal of Neurophysiology

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. Auditory cortical responses to electrical stimulation of the inferior colliculus: implications for an auditory midbrain implant. J Neurophysiol 96: 975-988, 2006. First published May 24, 2006 doi:10.1152/jn.01112.2005. The success and limitations of cochlear implants (CIs) along with recent advances in deep brain stimulation and neural engineering have motivated the development of a central auditory prosthesis. In this study, we investigated the effects of electrical stimulation of the inferior colliculus central nucleus (ICC) on primary auditory cortex (A1) activity to determine the potential benefits of an auditory midbrain implant (AMI). We recorded multiunit activity in A1 of ketamine-anesthetized guinea pigs in response to single-pulse (200 s/phase) monopolar stimulation of the ICC using multisite silicon-substrate probes. We then compared measures of threshold, dynamic range, and tonotopic spread of activation for ICC stimulation with that of published data for CI stimulation. Our results showed that compared with cochlear stimulation, ICC stimulation achieved: 1) thresholds about 8 dB lower; 2) dynamic ranges Ն4 dB greater; and 3) more localized, frequency-specific activation, even though frequency specificity was partially lost at higher stimulus levels for low-frequency ICC regions. Our results also showed that stimulation of rostral ICC regions elicited lower thresholds but with greater activation spread along the tonotopic gradient of A1 than did stimulation of more caudal regions. These results suggest that an AMI may improve frequency and level coding with lower energy requirements compared with CIs. However, a trade-off between lower perceptual thresholds and better frequency discrimination may exist that depends on location of stimulation along the caudorostral dimension of the ICC. Overall, this study provides the foundation for future AMI research and development.

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“…4 Using the methods for silicon processing borrowed from the microelectronics industry, researchers have begun to microfabricate neural prosthetic devices for stimulation and chronic recording of nerve cells. 5,6 These miniature devices can cause considerably less tissue damage and more focused stimulation than larger versions. 7 However, there are considerable challenges before these devices can be fully exploited.…”

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confidence: 99%

Three-Dimensionally-Patterned Submicrometer-Scale Hydrogel/Air Networks That Offer a New Platform for Biomedical Applications

et al. 2008

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Phase mask interference lithography was employed to fabricate three-dimensional (3D) hydrogel structures with high surface area on neural prosthetic devices. A random terpolymer of poly(hydroxyethyl methacrylate-ran-methyl methacrylate-ran-methacrylic acid) was synthesized and used as a negative-tone photoresist to generate bicontinuous 3D hydrogel structures at the submicrometer scale. We demonstrated that the fully open 3D hydrogel/air networks can be used as a pH-responsive polymeric drug-release system for the delivery of neurotrophins to enhance the performance of neural prosthetic devices. Additionally an open hydrogel structure will provide direct access of neuronal growth to the device for improved electrical coupling.

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Performance of planar multisite microprobes in recording extracellular single-unit intracortical activity

Cited by 332 publications

References 11 publications

Biomaterials for the central nervous system

Biomaterials for the central nervous system

Antidromic Activation Reveals Tonotopically Organized Projections From Primary Auditory Cortex to the Central Nucleus of the Inferior Colliculus in Guinea Pig

Three-Dimensionally-Patterned Submicrometer-Scale Hydrogel/Air Networks That Offer a New Platform for Biomedical Applications

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