Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration

Palin, Letícia Pitol; Frigério, Paula Buzo; Moura, Juliana de; Silva, Livia Pilatti Mendes da; Oliveira, Letícia Marques Jordão de; Matsubara, Elaine Yoshiko; Tunchel, Samy; Shibli, Jamil Awad; Blay, Alberto; Saska, Sybele; Okamoto, Roberta

doi:10.3390/polym15010031

Cited by 8 publications

(17 citation statements)

References 59 publications

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“…70,124,125 Given the persistent good mechanical properties, machinability, non-antigenity, low inflammatory reaction, and predictable degradation rate, it has been widely used in various medical applications, such as sutures, drug carriers, airway stents, biliary stents, tissue engineering scaffolds. 51,124,[126][127][128][129][130][131] Both the Pansy occluder and Memsorb occluder used PDO as the skeleton material, and clinical trial results were satisfactory. 51,52,[68][69][70][71][72] The complete degradation took around 6-24 months, and the loss of support strength was slow during degradation, hence, it could provide good support for 5-6 weeks.…”

Section: Polydioxanonementioning

confidence: 97%

“…Compared with other biodegradable polymers, like PGA and PLA, PDO produces less acidic products, elicits weaker inflammatory reactions, and has better flexibility and tensile strength 70,124,125 . Given the persistent good mechanical properties, machinability, non‐antigenity, low inflammatory reaction, and predictable degradation rate, it has been widely used in various medical applications, such as sutures, drug carriers, airway stents, biliary stents, tissue engineering scaffolds 51,124,126–131 …”

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

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Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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Section: Polydioxanonementioning

confidence: 97%

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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“…The peak sintering temperature of 1200°C resulted in a single and pure β-TCP phase (purity ≤ 95%). [37]…”

Section: Printing Of Scaffoldsmentioning

confidence: 99%

“…The animals were euthanized by anesthetic overdosage of xylazine hydrochloride and ketamine hydrochloride at 7 (n=6 per group), 15 (n=6 per group), and 30 days (n=6 per group) after the surgical procedure. [37] 4.5. Laboratorial Processing…”

Section: Surgical Proceduresmentioning

confidence: 99%

Cell-Based Tissue Engineering for Guided Bone Regeneration in Rats: A Preliminary Study with 3D-Printed β-Tricalcium Phosphate Scaffolds and Polydioxanone Membranes

Pitol-Palin,

Moura,

Frigério

et al. 2024

Preprint

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Treatment of complex craniofacial deformities is still a challenge for medicine and dentistry because few approach therapies are available on the market that allows rehabilitation using 3D-printed medical devices. Thus, this preliminary study aims to evaluate the bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) scaffolds and polydioxanone membrane (PDO) with cell-based (ASCs) tissue engineering for guided bone regeneration in critical calvary defects of rats. Methods: Male rats were divided into three groups: β-TCP + PDO membrane (TCP/PG), β-TCP/ASCs + PDO membrane (TCPasc/PG), and β-TCP/ASCs + PDO membrane/ASCs (TCPasc/PGasc). A surgical defect in the right parietal bone was made, and the defect was filled with the 3D-printed β-TCP scaffold and PDO membrane with or without ASCs. The animals were euthanized 7, 14, and 30 days after the surgical procedure for histomorphometric and immunolabeling analyses. Results: Cell-based therapy promotes, especially in the TCPasc/PGasc group, a bone area formation at the defect border region and the center of the defect. Conclusions: Using 3D-printed β-TCP scaffolds and PDO membranes associated with cell-based therapy has excellent potential to improve and accelerate guided bone regeneration. Moreover, using ASCs optimized the bioceramics by increasing its osteoinductive and osteoprogenitor capacity even with the resorption of the printed scaffold.

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“…Synthetic resorbable membranes are designed to be biocompatible and to degrade over time, allowing the body to absorb them and promoting the regeneration of new bone tissue. Some examples of synthetic resorbable membranes for GBR include polylactic acid (PLA), − polyglycolide (PGA), , poly(lactic- co -glycolic) acid (PLGA), , polydioxanone (PDO), , polycaprolactone (PCL), − and polyethylene glycol (PEG) membranes. , However, synthetic bioresorbable membranes also suffer from lack of control over the resorption rate dictated by factors like local pH and lack of inertness because of unfavorable reactions during degradation (Figure ). …”

Section: Synthetic Resorbable Membranesmentioning

confidence: 99%

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

et al. 2023

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Lack of horizontal and vertical bone at the site of an implant can lead to significant clinical problems that need to be addressed before implant treatment can take place. Guided bone regeneration (GBR) is a commonly used surgical procedure that employs a barrier membrane to encourage the growth of new bone tissue in areas where bone has been lost due to injury or disease. It is a promising approach to achieve desired repair in bone tissue and is widely accepted and used in approximately 40% of patients with bone defects. In this Review, we provide a comprehensive examination of recent advances in resorbable membranes for GBR including natural materials such as chitosan, collagen, silk fibroin, along with synthetic materials such as polyglycolic acid (PGA), polycaprolactone (PCL), polyethylene glycol (PEG), and their copolymers. In addition, the properties of these materials including foreign body reaction, mechanical stability, antibacterial property, and growth factor delivery performance will be compared and discussed. Finally, future directions for resorbable membrane development and potential clinical applications will be highlighted.

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Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration

Cited by 8 publications

References 59 publications

Progress of biodegradable polymer application in cardiac occluders

Progress of biodegradable polymer application in cardiac occluders

Cell-Based Tissue Engineering for Guided Bone Regeneration in Rats: A Preliminary Study with 3D-Printed β-Tricalcium Phosphate Scaffolds and Polydioxanone Membranes

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations

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