Performance of Rapid Syphilis Tests in Venous and Fingerstick Whole Blood Specimens

Siedner, Mark J.; Zapitz, Virginia M.; Ishida, Masatoshi; Roca, Romeo De La; Klausner, Jeffrey D.

doi:10.1097/01.olq.0000137903.48413.5e

Cited by 47 publications

(36 citation statements)

References 5 publications

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“…16 The rationale of this approach should be discussed with the patient. † Rapid tests for syphilis are available 41 but their main role is likely to be in field conditions in developing countries and potentially in outreach work. † Neurological imaging should be considered in those with neurological symptoms or signs.…”

Section: Classificationmentioning

confidence: 99%

UK National Guidelines on the Management of Syphilis 2008

Kingston¹,

et al. 2008

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HIV-positive patients: Treat as appropriate for stage of infection, that is, HIV-positive patients are treated with the same regimens as HIV-negative patients † Management of sexual partners: Recognition that partner notification may be difficult in context of current syphilis outbreaks and achieving 60% partner notification rates is not always possible and screening in high-risk venues may be appropriate. † Auditable outcomes: Measuring rapid plasma reagin test (RPR)/Venereal Diseases Research Laboratory (VDRL) at commencement of therapy introduced as an auditable outcome. † Appendices:-Reference to sources of procaine penicillin G-Use of lidocaine as diluent for Benzathine penicillin G DIAGNOSIS History and examination † Symptoms of early syphilis † Details of previous treatment (place of treatment, diagnosis made, treatment given, RPR/VDRL titre at discharge) † Obstetric history, potential complications of syphilis e.g. miscarriages, stillbirths † Blood donation and antenatal screening history † Other treponemal infections; yaws, pinta and a history of living in countries where these conditions are endemic † In early infection examination of the genitals, skin, mucosal surfaces and lymph nodes for signs of primary and secondary syphilis. † In late and congenital syphilis a thorough clinical examination should be undertaken for the clinical manifestations of syphilis. This should include a full systems review including skin and mucosal surfaces, lymph nodes, cardiovascular and neurological systems.

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Section: Classificationmentioning

confidence: 99%

UK National Guidelines on the Management of Syphilis 2008

Kingston¹,

et al. 2008

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“…New treponemal tests that are faster and less expensive are also being developed for use in low-prevalence populations and resourcepoor environments. [85][86][87][88][89][90] Unfortunately, despite the fact that many of these rapid treponemal tests have shown great performance and potential for rapid, point-of-care screening, manufacturers have not sought Food and Drug Administration clearance.…”

Section: Interpretation Of Serological Test Results During Follow-upmentioning

confidence: 99%

Syphilis in the United States: An Update for Clinicians With an Emphasis on HIV Coinfection

Zetola

Engelman

Jensen

et al. 2007

Mayo Clinic Proceedings

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114

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Diagnosis and treatment of syphilis are challenging because of its variable clinical presentation and course and the lack of definitive tests of cure after treatment. This review of the most recent literature on the epidemiology, clinical manifestations, current diagnosis, and treatment of syphilis is focused toward clinicians who treat patients with this disease. Syphilis coinfection with human immunodeficiency virus is emphasized because it is increasingly common in the United States and affects the initial presentation, disease course, diagnosis, and treatment of syphilis. Of particular consequence is the effect of human immunodeficiency virus on the clinical diagnosis, prevalence, and course of neurosyphilis, one of the most serious consequences of syphilis infection. linicians from large metropolitan areas frequently face the challenge of diagnosing syphilis and treating patients with syphilis. In doing so, they are often faced with questions regarding interpretation of clinical findings and laboratory results and selection of appropriate therapy. Interpretation of the data available to answer these questions is often challenging given the paucity of large well-designed studies and the substantial variability that characterizes the clinical presentation of syphilis. Such a challenge is particularly found in the treatment of patients coinfected with syphilis and human immunodeficiency virus (HIV). To guide clinicians in this difficult task, we discuss the most recent literature on the epidemiology, clinical manifestations, diagnosis, and treatment of syphilis and the corresponding effects of HIV coinfection.

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“…In addition, as the levels of treponemal antibodies may be very low in the serum of early primary syphilis patients, the sensitivities of treponemal tests may also vary in their reactivity [5]. The lower antibody concentrations could decrease test sensitivity by diminishing the strength of the antigen-antibody interactions that are responsible for producing a positive test result [20].…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the Determine Syphilis TP assay for the detection of antibodies against Treponema pallidum for the serodiagnosis of syphilis

Zhuang

Tian

Chen

et al. 2011

Eur J Clin Microbiol Infect Dis

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Currently, infectious syphilis has been resurgent in China and has become a significant public health problem. The rapid expansion of syphilis screening programs is urgently required. In the present study, the performance of the Determine Syphilis TP assay (Determine TP assay) for the detection of antibodies against Treponema pallidum (T. pallidum) for syphilis serodiagnosis was evaluated. In total, 300 serum samples were tested for the presence of treponemal-specific antibodies using the Treponema pallidum particle agglutination (TPPA) assay, the Determine TP assay, and the InTec immunochromatography assay (InTec assay). The Determine TP assay detected 99, 11, and 5 positive results, whereas the InTec assay detected 97, 3, and 3 positive samples from group I (100 TPPA-positive sera), group II (13 TPPA 1:80 +/- sera), and group III (187 TPPA-negative sera), respectively. The sensitivity, specificity, and the rate concordant with TPPA for the Determine TP assay were 97.35, 98.91, and 97.33%, respectively. In comparison to the TPPA, the Determine TP assay is simple to perform and time-saving, making it a favorable alternative for the detection of T. pallidum-specific antibodies where other T. pallidum-specific confirmatory tests are not available. In addition, this rapid treponemal test promotes prompt treatment for syphilis by providing early laboratory diagnosis.

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Performance of Rapid Syphilis Tests in Venous and Fingerstick Whole Blood Specimens

Abstract: The Abbott Determine TP test was an easy and accurate test that could facilitate rapid detection of syphilis in at-risk patients.

Cited by 47 publications

References 5 publications

UK National Guidelines on the Management of Syphilis 2008

UK National Guidelines on the Management of Syphilis 2008

Syphilis in the United States: An Update for Clinicians With an Emphasis on HIV Coinfection

Evaluation of the Determine Syphilis TP assay for the detection of antibodies against Treponema pallidum for the serodiagnosis of syphilis

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