Recent development of research conducted in Japan into computer applications in bio-pro cess engineering is summarized, specially focusing on the application of knowledge engineering approaches to bio-process control. The issues of methodological investigation, their applications in process development, and examples of industrial applications of expert systems, artificial biotechnologia 4 (47) '99
11ÓToshiomi Yoshida neural networks, fuzzy theory, and genetic algorithm are thoroughly reviewed, and some repre sentative recent works are introduced more extensively.