Performance of the BD Veritor system SARS-CoV-2 antigen test among asymptomatic collegiate athletes: A diagnostic accuracy study

Kepczynski, Casey M.; Genigeski, Jaelin A.; Regnier, Daniel P. de; Jadhav, Emmanuel D.; Sohn, Minji; Klepser, Michael E.

doi:10.1016/j.rcsop.2021.100047

Cited by 1 publication

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“…RT-qPCR testing and other forms of testing (such as molecular point-of-care assays or serological testing) have been characterized and described as diagnostic approaches for SARS-CoV-2 elsewhere (Carter et al, 2020). Several assay characteristics, including time to result (Peeling et al, 2021), analytical sensitivity (Mak et al, 2020), cost per test (Neilan et al, 2020;Kepczynski et al, 2021;Love et al, 2021;Jakobsen et al, 2021b), infrastructure requirements for testing (Augustin et al, 2020), and volume of testing (Carter et al, 2020), need to be considered before determining the most appropriate testing strategy. As the priorities for specific test characteristics differ between testing sites, so does the overall value of a given diagnostic test.…”

Section: Discussionmentioning

confidence: 99%

Factors that Influence the Reported Sensitivity of Rapid Antigen Testing for SARS-CoV-2

et al. 2021

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Tests that detect the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigen in clinical specimens from the upper respiratory tract can provide a rapid means of coronavirus disease 2019 (COVID-19) diagnosis and help identify individuals who may be infectious and should isolate to prevent SARS-CoV-2 transmission. This systematic review assesses the diagnostic accuracy of SARS-CoV-2 antigen detection in COVID-19 symptomatic and asymptomatic individuals compared to quantitative reverse transcription polymerase chain reaction (RT-qPCR) and summarizes antigen test sensitivity using meta-regression. In total, 83 studies were included that compared SARS-CoV-2 rapid antigen-based lateral flow testing (RALFT) to RT-qPCR for SARS-CoV-2. Generally, the quality of the evaluated studies was inconsistent; nevertheless, the overall sensitivity for RALFT was determined to be 75.0% (95% confidence interval: 71.0–78.0). Additionally, RALFT sensitivity was found to be higher for symptomatic vs. asymptomatic individuals and was higher for a symptomatic population within 7 days from symptom onset compared to a population with extended days of symptoms. Viral load was found to be the most important factor for determining SARS-CoV-2 antigen test sensitivity. Other design factors, such as specimen storage and anatomical collection type, also affect the performance of RALFT. RALFT and RT-qPCR testing both achieve high sensitivity when compared to SARS-CoV-2 viral culture.

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