The accurate calculation of reactor core heating is vital for the design and safety analysis of reactor physics. However, negative KERMA factors may be produced when processing and evaluating libraries of the nuclear data files ENDF/B-VII.1 and ENDF/B-VIII.0 with the NJOY2016 code, and the continuous-energy neutron cross-section library ENDF71x with MCNP also has the same problem. Negative KERMA factors may lead to an unreasonable reactor heating rate. Therefore, it is important to investigate the influence of negative KERMA factors on the calculation of the heating rate. It was also found that negative KERMA factors can be avoided with the CENDL-3.2 library for some nuclides. Many negative KERMA nuclides are found for structural materials; there are many non-fuel regions in fast reactors, and these negative KERMA factors may have a more important impact on the power distribution in non-fuel regions. In this study, the impact of negative KERMA factors on power calculation was analyzed by using the RBEC-M benchmark and replacing the neutron cross-section library containing negative KERMA factors with one containing normal KERMA factors that were generated based on CENDL-3.2. For the RBEC-M benchmark, the deviation in the maximum neutron heating rate between the negative KERMA library and the normal library was 6.46%, and this appeared in the reflector region. In the core region, negative KERMA factors had little influence on the heating rate, and the deviations in the heating rate in most assemblies were within 1% because the heating was mainly caused by fission. However, in the reflector zone, where gamma heating was dominant, the total heating rate varied on account of the gamma heating rate. Therefore, negative KERMA factors for neutrons have little influence on the calculation of fast reactor heating according to the RBEC-M benchmark.