Performance of the CKD-EPI Equation to Estimate GFR in a Longitudinal Study of Autosomal Dominant Polycystic Kidney Disease

Shen, Chengli; Landsittel, Douglas; Irazabal, María V.; Yu, Alan; Chapman, Arlene B.; Mrug, Michal; Bae, Kyongtae T.; Bennett, William M.; Flessner, Michael F.; Torres, Vicente E.

doi:10.1053/j.ajkd.2016.10.021

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…All non-PKD kidney tissues were collected from patients with intra-renal tumors, as previously described ( Zimmerman et al, 2019c ). The eGFR estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula ( Shen et al, 2017 ) in non-PKD controls was in the range of 58-120 (average 89) ml/min/1.73m 2 ( Table S1 ). The average age of ADPKD patients was lower (53±11 years) than that of non-PKD controls (58±13 years; P =0.542).…”

Section: Methodsmentioning

confidence: 99%

A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models

Zimmerman

Cherakara

et al. 2023

Disease Models &Amp; Mechanisms

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Although renal macrophages have been shown to contribute to cystic kidney disease in PKD animal models, it remains unclear if there is a specific macrophage subpopulation involved. Here we analyze changes in macrophage populations during renal maturation in association with cystogenesis rates in conditional Pkd2 mutant mice. We demonstrate that CD206+ resident macrophages are minimal in a normal adult kidney but accumulate in cystic areas in adult-induced Pkd2 mutants. Using Cx3cr1 null mice, we reduced macrophage number, including CD206+ macrophages, and show this significantly reduces cyst severity in adult-induced Pkd2 mutant kidneys. We also found that the number of CD206+ resident macrophage-like cells increases in kidneys and in the urine from ADPKD patients relative to the rate of renal functional decline. These data indicate a direct correlation between CD206+ resident macrophages and cyst formation and demonstrate that the CD206+ resident macrophages in urine may serve as a biomarker for renal cystic disease activity in preclinical models and ADPKD patients.

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Section: Methodsmentioning

confidence: 99%

A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models

Zimmerman

Cherakara

et al. 2023

Disease Models &Amp; Mechanisms

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“…The different methods of kidney function measurement in ADPKD were compared in 5 studies. 101,[186][187][188][189] Patients with ADPKD face many challenges because of their disease and pain remains one of the most common symptoms they must deal with. Pain severity varies, which can be a frustrating problem that adversely affects QoL.…”

Section: Composite Endpointsmentioning

confidence: 99%