We are witnessing significant climatic changes and increasingly frequent extreme weather conditions affecting every part of the globe. In order to reduce and stop these unfavourable climate changes, there has been a shift to the use of renewables, and in this sense, a significant contribution of the photovoltaic (PV) power plant is planned. This paper analyses the safety, reliability, and resilience of PV systems to extreme weather conditions such as wind storms, hail, lightning, high temperatures, fire, and floods. In addition to using available information from the literature, temperature measurements were also carried out on the rooftop PV power plant in Slavonski Brod, as well as a numerical stress analysis at extreme wind speeds using Ansys software. The results of the analysis show that existing PV systems are very resilient to extreme weather conditions. Utility-scale PV systems can usually withstand wind speeds of up to 50 m/s without any problems, and only at higher speeds do local stresses occur in certain parts of the structure that are higher than permissible. Resistance to hail is also very high, and manufacturers guarantee resistance to hail up to 25 mm in size. At high air temperatures, the temperature of the panel frame can reach about 70 °C, the panel temperature up to 85 °C, and the temperature of the cable insulation over 60 °C, as measurements have shown. Such high temperatures lead to a drop in electricity production up to 30% but do not pose a fire hazard to the cables and the roof if the roof insulation is conducted correctly. Forest fires do not usually pose a direct threat to PV systems, but the smoke that spreads over a large area reduces the solar radiation reaching the PV panel. It can also cause an unfavourable “wiggle effect”. Lightning strikes to a PV panel are not common, although they are possible. With built-in safeguards, no major damage should occur. Flooding is always a possibility, but with properly designed drainage systems, the damage is minimal in most cases.