Performance on the APACHE II, SAPS II, SOFA and the OHCA score of post-cardiac arrest patients treated with therapeutic hypothermia

Abstract

ObjectiveThis study assessed the ability of the Acute Physiologic and Chronic Health Evaluation (APACHE) II score, Simplified Acute Physiology Score (SAPS) II, Sequential Organ Failure Assessment (SOFA) score, and out-of-hospital cardiac arrest (OHCA) score to predict the outcome of OHCA patients who underwent therapeutic hypothermia (TH).MethodsThis study included OHCA patients treated with TH between January 2010 and December 2013. The APACHE II score, SAPS II, and SOFA score were calculated at the time of admission and 24 h and 48 h after intensive care unit admission. The OHCA score was calculated at the time of admission. The area under the curve (AUC) of the receiver operating characteristic curve and logistic regression analysis were used to evaluate outcome predictability.ResultsData from a total of 173 patients were included in the analysis. The APACHE II score at 0 h and 48 h, SAPS II at 48 h, and OHCA score had moderate discrimination for mortality (AUC: 0.715, 0.750, 0.720, 0.740). For neurologic outcomes, the APACHE II score at 0 h and 48 h, SAPS II at 0 h and 48 h, and OHCA score showed moderate discrimination (AUC: 0.752, 0.738, 0.771, 0.771, 0.764). The APACHE II score, SAPS II and SOFA score at various time points, in addition to the OHCA score, were independent predictors of mortality and a poor neurologic outcome.ConclusionsThe APACHE II score, SAPS II, SOFA score, and OHCA score have different capabilities in discriminating and estimating hospital mortality and neurologic outcomes. The OHCA score, APACHE II score and SAPS II at time zero and 48 h offer moderate predictive accuracy. Other scores at 0 h and 48 h, except for the SOFA score, are independently associated with 30-day mortality and poor cerebral performance.

Association of extracerebral organ failure with 1-year survival and healthcare-associated costs after cardiac arrest: an observational database study

“…Previous studies have shown an association of admission SOFA and EC-SOFA with 28-/30-day mortality in single-centre settings of OHCA patients [13, 24, 25]. Association with neurologic outcome has produced conflicting results [24, 25].…”

Prognostic value of OHCA, C-GRApH and CAHP scores with initial neurologic examinations to predict neurologic outcomes in cardiac arrest patients treated with targeted temperature management

“…Recently, each prediction model has been compared with others, improved by adding new factors, or validated based on several other demographic features to overcome worldwide variations [1,[11][12][13]. However, there is still a shortage of external validation studies, and no…”

The value of neutrophil gelatinase-associated lipocalin and citrullinated alpha enolase peptide-1 antibody in diagnosis, classification, and prognosis for patients with sepsis

“…[ 26 , 27 ] APACHE II score is more likely to evaluate the severity of the disease, while SOFA score is more inclined to evaluate the organ injury of the patient Though the sensitivity of assessment ability varies between them, both are associated with severity or mortality for critically patients. [ 28 ] It may be more persuasive to use both scores together. Our results also showed that these 2 scores were associated with sepsis severity.…”

“…OF note, PCT was only molecule significantly correlated with both the APACHE II score ( r = 0.36) and SOFA score ( r = 0.50) as observed previously. [ 28 ] Additionally, plasma NGAL ( r = 0.31) was positively correlated with SOFA score. Quantitatively, PCT and NGAL concentrations were significantly higher in the sepsis shock group than in the sepsis group.…”