A multiobjective optimization technique based on the computational uid dynamics (CFD) simulations and the orthogonal test is proposed to reduce the pressure pulsation in this paper. ree levels of four well-known performance factors L 9 (3 4 ) were considered in the orthogonal test scheme: the number of blades, the blade setting angle, the hub ratio, and the distance between the blade and the guide vane. e evaluation indexes corresponded to the head, e ciency, shaft power, and pressure pulsation, respectively. An optimal con guration A 2 B 1 C 2 D 3 was obtained by comprehensive frequency analysis method, after intuitive and range analysis. In comparison with the nonoptimized model, the new design's head and e ciency increased by 17.8% and 4.26%, whilst the shaft power and the pressure pulsation coe cient reduced by 1.22% and 11%, respectively. Experiments conducted on the optimized pump were consistent with the CFD model. Six di erent rotational speed conditions in the optimal operating points were numerically calculated in order to explore the internal hydraulic characteristics of the optimized axial ow pump. It is veri ed that the comprehensive frequency analysis method based on the orthogonal test approach is e ective for the multiobjective optimization of the axial ow pump.