Traditionally,alarger number of experiments are needed to optimize the performance of the membrane electrode assembly (MEA) in proton-exchange membrane fuel cells (PEMFCs) since it involves complex electrochemical, thermodynamic,a nd hydrodynamic processes.H erein, we introduce artificial intelligence (AI)-aided models for the first time to determine key parameters for nonprecious metal electrocatalyst-based PEMFCs,t hus avoiding unnecessary experiments during MEA development. Among 16 competing algorithms widely applied in the AI field, decision tree and XGBoost showed good accuracy (86.7 %and 91.4 %) in determining key factors for high-performance MEA. Artificial neural network (ANN) shows the best accuracy (R2 = 0.9621) in terms of predictions of the maximum power density and ad ecent reproducibility (R2 > 0.99) on uncharted I-V polarization curves with 26 input features.H ence,m achine learning is shown to be an excellent method for improving the efficiency of MEA design and experiments.