Performance profile of FDG-PET and PET/CT for cancer screening on the basis of a Japanese Nationwide Survey

Minamimoto, Ryogo; Senda, Michio; Uno, Kimiichi; Jinnouchi, Seishi; Iinuma, Takeshi; Ito, Kengo; Okuyama, Chio; Oguchi, Kazuhiro; Kawamoto, Masami; Suzuki, Yutaka; Tsukamoto, Eriko; Terauchi, Takashi; Nakashima, Rumi; Nishio, Masami; Nishizawa, Sadahiko; Fukuda, Hiroshi; Yoshida, Tsuyoshi; Inoue, Tomio

doi:10.1007/s12149-007-0061-8

Cited by 57 publications

(54 citation statements)

References 10 publications

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“…This may be due to our close examination of all focal PET incidentalomas using US and FNAB and the long-term follow-up. The mean age of 1,501 subjects in our study was 43.7 years old, about 10 years younger than in the study by Chen et al (52.8 years old) and Minamimoto et al (the median age corresponded to the group of 50-59 years old) [6,7]. Given that the incidence of thyroid nodule and thyroid cancer increases with age [8], it is surprising that we found a higher incidence of thyroid cancer in our relatively younger subjects.…”

Section: Resultscontrasting

confidence: 60%

“…In our current study, thyroid cancer was proven in 11 of 20 focal PET incidentalomas in 1,501 healthy subjects. The cancer risk was 55%, markedly higher than in previous reports [1,6,7]. This may be due to our close examination of all focal PET incidentalomas using US and FNAB and the long-term follow-up.…”

Section: Resultsmentioning

confidence: 48%

“…It has been reported that the incidence of thyroid cancer in PET incidentaloma is about 30 to 50% by FDG-PET in systemic work-up of patients with malignancy in extra-thyroidal regions [1−5]. In healthy subjects who underwent general cancer screening, 6.7% to 32.9% of PET incidentalomas have been proven to be thyroid cancer [1,6,7]. These studies were all performed in subjects of relatively advanced age (mean ≥ 50 years old).…”

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confidence: 99%

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High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

et al. 2010

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Abstract. As 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is becoming a common imaging modality, the number of thyroid incidentalomas identified by FDG-PET (PET incidentaloma) is increasing. The purpose of this study was to elucidate the risk of cancer in focal thyroid PET incidentaloma in healthy subjects of relatively younger age as well as the usefulness of repeated FDG-PET. The study was conducted with an observation period of three years. A total of 1,501 healthy volunteers (mean age, 43.5±9.7 years) underwent the first FDG-PET from August 2003 to July 2004. When focal thyroid PET incidentaloma was found, further diagnostic examination was conducted. When thyroid cancer was suspected, surgical resection was performed with the patient's agreement. Patients with PET incidentaloma without surgery were offered annual US and FDG-PET and finally FNAB was performed in the fourth year. Focal thyroid PET incidentaloma was observed in 20 subjects. The final diagnoses in 20 subjects were malignant in 11 (ten papillary thyroid carcinoma (PTC) and one thyroid carcinoma showing thymus-like differentiation), indeterminate in one, and benign in eight subjects. Seven patients not treated surgically at the first examination had annual FDG-PET. One patient with PTC showed increasing SUVmax, but another with a benign nodule exhibited a similar increase. Others (one with PTC, one with an indeterminate nodule, and three with benign nodules) exhibited negligible SUVmax changes. When closely examined, focal thyroid PET incidentaloma in relatively young healthy adults has a high probability of malignancy. Repeated FDG-PET to follow up patients with thyroid nodules is ineffective.

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Section: Resultscontrasting

confidence: 60%

Section: Resultsmentioning

confidence: 48%

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confidence: 99%

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High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

et al. 2010

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“…Although PET has recently been proposed as a promising cancer screening test [47,48], the utility of PET in gastric cancer screening has not been evaluated. For gastric cancer screening, the usefulness of PET is limited because of physiological FDG uptake in the normal gastric wall and differences of FDG uptake according to the histological type of the tumor [1,2].…”

Section: Efficacy Of Pet For the Screening Of Gastric Cancermentioning

confidence: 99%

“…According to a multi-institutional study conducted by the Japanese Society of Nuclear Medicine and the Japan Radioisotope Association for cancer screening including PET, 30 cases of gastric cancer were found in 50,558 healthy subjects [47]. PET showed a relative sensitivity of 27% and PPV of 16%.…”

Section: Efficacy Of Pet For the Screening Of Gastric Cancermentioning

confidence: 99%

Japanese Gastric Cancer Association Task Force for Research Promotion: clinical utility of 18F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature

et al. 2011

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Since April 2010, the Japanese Public Health Insurance System has covered the costs incurred for performing 18 F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) imaging for patients with advanced gastric cancer. The aim of this review was to evaluate the clinical impact of PET for patients with gastric cancer. A systematic literature search was performed in PubMed/MEDLINE using the keywords ''gastric cancer'' and ''PET'' to search for relevant articles published from January 2000 to September 2010. The clinical impact of selected articles was assessed by the authors to evaluate the following: (a) tumor staging, (b) diagnosis for recurrent disease, (c) evaluation of treatment response, and (d) screening for gastric cancer. FDG uptake increases in papillary adenocarcinoma, tubular adenocarcinoma, and solid-type poorly differentiated adenocarcinoma. This uptake is also associated with glucose transporter 1 expression. The sensitivity and specificity of FDG-PET for metastatic lymph node detection were 21-40% and 89-100%, respectively. The sensitivity and specificity for distant metastasis detection were 35-74% and 74-99%, respectively. Treatment response can be detectable at an earlier stage by PET than by computed tomography (CT), because FDG uptake by cancer cells decreases according to the treatment response. In summary, although PET has limitations such as frequent false-negative cases in signetring cell carcinoma and non-solid type poorly differentiated carcinoma, it can contribute to the selection of a more appropriate treatment modality by detecting distant metastases and treatment response.

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Cytological evaluation by fine needle aspiration biopsy of incidental focal increased fluorodeoxyglucose uptake in thyroid on positron emission tomography scan

Cui

Azar

et al. 2017

Diagnostic Cytopathology

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Performance profile of FDG-PET and PET/CT for cancer screening on the basis of a Japanese Nationwide Survey

Cited by 57 publications

References 10 publications

High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodexyglucose positron emission tomography in relatively young healthy subjects: results of 3-year follow-up

Japanese Gastric Cancer Association Task Force for Research Promotion: clinical utility of 18F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature

Cytological evaluation by fine needle aspiration biopsy of incidental focal increased fluorodeoxyglucose uptake in thyroid on positron emission tomography scan

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