Performance status as a significant prognostic predictor in patients with urothelial carcinoma of the bladder who underwent radical cystectomy

Hinata, Nobuyuki; Miyazaki, Akira; Nishikawa, Masatomo; Tei, Hiromoto; Fujisawa, Masato

doi:10.1111/iju.12804

Cited by 22 publications

(21 citation statements)

References 21 publications

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“…1 . The initial search yielded a total of 495 potentially relevant abstracts, among which 16 articles 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 met all inclusion criteria. A total of 5,232 patients with UC were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Cao

Zhao

Zhong

et al. 2016

Sci Rep

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The effect of pre-operative renal insufficiency on urothelial carcinoma (UC) prognosis has been investigated by numerous studies. While the majority report worse UC outcomes in patients with renal insufficiency, the results between the studies differed wildly. To enable us to better estimate the prognostic value of renal insufficiency on UC, we performed a systematic review and meta-analysis based on the published literature. A total of 16 studies which involved 5,232 patients with UC, investigated the relationship between pre-operative renal insufficiency and disease prognosis. Estimates of combined hazard ratio (HR) for bladder urothelial carcinoma recurrence, cancer-specific survival (CSS) and overall survival (OS) were 1.65 (95% CI, 1.11–2.19), 1.59 (95% CI, 1.14–2.05) and 1.45 (95% CI, 1.19–1.71), respectively; and for upper urinary tract urothelial carcinoma recurrence, CSS and OS were 2.27 (95% CI, 1.42–3.12), 1.02 (95% CI, 0.47–1.57) and 1.52 (95% CI, 1.05–1.99), respectively. Our results indicate that UC patients with pre-operative renal insufficiency tend to have higher recurrence rates and poorer survival compared to those with clinically normal renal function, thus renal function should be closely monitored in these patients. The impact of intervention for renal insufficiency on the prognosis of UC needs to be further studied.

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Section: Resultsmentioning

confidence: 99%

Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Cao

Zhao

Zhong

et al. 2016

Sci Rep

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“…A study of 1,249 cases from Chen et al found that a low BMI might be associated with poorer survival among patients with stage III–IV GC 13. Hinata et al reported that impaired performance status was associated with an unfavorable prognosis in patients with urothelial carcinoma of the bladder who underwent radical cystectomy 14. One recent study revealed that preoperative PNI values maybe a useful predictor of long-term survival in patients with stage I and II GC 15.…”

Section: Introductionmentioning

confidence: 99%

Gastric cancer, nutritional status, and outcome

Liu¹,

Qiu²,

Kong³

et al. 2017

OTT

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BackgroundWe aim to investigate the prognostic value of several nutrition-based indices, including the prognostic nutritional index (PNI), performance status, body mass index, serum albumin, and preoperative body weight loss in patients with gastric cancer (GC).Materials and methodsWe retrospectively analyzed the records of 1,330 consecutive patients with GC undergoing curative surgery between October 2000 and September 2012. The relationship between nutrition-based indices and overall survival (OS) was examined using Kaplan–Meier analysis and Cox regression model.ResultsFollowing multivariate analysis, the PNI and preoperative body weight loss were the only nutritional-based indices independently associated with OS (hazard ratio [HR]: 1.356, 95% confidence interval [CI]: 1.051–1.748, P=0.019; HR: 1.152, 95% CI: 1.014–1.310, P=0.030, retrospectively). In stage-stratified analysis, multivariate analysis revealed that preoperative body weight loss was identified as an independent prognostic factor only in patients with stage III GC (HR: 1.223, 95% CI: 1.065–1.405, P=0.004), while the prognostic significance of PNI was not significant (all P>0.05). In patients with stage III GC, preoperative body weight loss stratified 5-year OS from 41.1% to 26.5%. When stratified by adjuvant chemotherapy, the prognostic significance of preoperative body weight loss was maintained in patients treated with surgery plus adjuvant chemotherapy and in patients treated with surgery alone (P<0.001; P=0.003).ConclusionPreoperative body weight loss is an independent prognostic factor for OS in patients with GC, especially in stage III disease. Preoperative body weight loss appears to be a superior predictor of outcome compared with other established nutrition-based indices.

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“…Of these, 6 did not provide sufficient clinical or endpoint data, 5 used inapplicable cut-off values and 1 was a duplicate. The remaining 12 publications [ 16 – 18 , 22 – 30 ] were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Prognostic implications of preoperative anemia in urothelial carcinoma: A meta-analysis

Luo

Wang

et al. 2017

PLoS ONE

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The prognostic significance of preoperative anemia (PA) has been identified in various malignancies. However, its predictive role in urothelial carcinoma (UC) remains controversial. The aim of this study was to investigate the prognostic value of PA in UC patients. We performed a meta-analysis of the association between PA and survival outcome in UC patients. Electronic databases were searched up to June 30, 2016. Study characteristics and prognostic data were extracted from each included study. Cancer-specific survival (CSS), recurrence-free survival (RFS), and overall survival (OS) were pooled using hazard ratio (HR) with corresponding 95% confidence intervals (CI). Herein, 12 studies comprising 3815 patients were included in the meta-analysis. There were 1593 (41.76%) patients in the PA group and 2222 (58.24%) in the control group. The overall pooled HRs of PA for CSS, RFS, and OS were significant at 2.21, (95% CI: 1.83–2.65, Pheterogeneity = 0.49, I2 = 0%), 1.87 (95% CI: 1.59–2.20, Pheterogeneity = 0.22, I2 = 28%), and 2.04(95% CI: 1.76–2.37, Pheterogeneity = 0.36, I2 = 9%) respectively. Stratified analyses indicated that PA was a predictor of poor prognosis based on ethnicity, sample size, tumor T stage, G grade, lymphovascular invasion (LVI), concomitant carcinoma in situ (CIS), and follow-up values. Our findings show that PA has negative prognostic effects on the survival outcome (CSS, RFS, and OS) in UC patients and can serve as a useful and cost-effective marker to aid prognosis prediction.

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Performance status as a significant prognostic predictor in patients with urothelial carcinoma of the bladder who underwent radical cystectomy

Cited by 22 publications

References 21 publications

Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Gastric cancer, nutritional status, and outcome

Prognostic implications of preoperative anemia in urothelial carcinoma: A meta-analysis

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