Performance Study of Whole-Body, Multislice Positron Computed Tomograph POSITOLOGICA-II

Takami, Katsumi; Ueda, Kazuhiko; Okajima, Kenichi; Tanaka, Eiichi; Nohara, Norimasa; Tomitani, Takehiro; Yamamoto, Mikio; Murayama, Hideo; Shishido, Fumio; Ishimatsu, Kenji; OHGUSHI, Akira; Inoue, Shinichi; Takakusa, Yasuo; Hayashi, T.; Nakase, Setsuo

doi:10.1109/tns.1983.4332367

Cited by 11 publications

(1 citation statement)

References 8 publications

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“…A whole-body, three-ring positron emission tomography system was used to follow the radioactivity in five sections covering an axial field of view of 72 mm of the brain (Takami et al 1983). The intervals between the section midpoints were 18 mm.…”

Section: Methodsmentioning

confidence: 99%

D1 dopamine receptor binding in mood disorders measured by positron emission tomography

Suhara

Nakayama

Ito³

et al. 1992

Psychopharmacology

153

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D1 dopamine receptor binding in mood disorders was studied by positron emission tomography (PET) using 11C-SCH23390. Ten patients with bipolar mood disorders and 21 normal controls were studied in the drug-free state. The patients were in euthymic (N = 6), depressed (N = 3) and manic (N = 1) states. Regional radioactivity in the brain was followed for 40 min by PET. A two-compartment model was used to obtain the binding potential (k3/k4) for the striatum and frontal cortex. The binding potentials for the frontal cortex for the patients were significantly lower than those for normal controls, whereas those for striatum were not significantly different. These findings suggest that D1 dopamine receptors in the frontal cortex may be in a different state in patients with bipolar mood disorders.

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Section: Methodsmentioning

confidence: 99%

D1 dopamine receptor binding in mood disorders measured by positron emission tomography

Suhara

Nakayama

Ito³

et al. 1992

Psychopharmacology

153

View full text Add to dashboard Cite

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Meßtechnik in der Emissions-Computertomographie

Jordan¹

1988

Nuklearmedizin / Nuclear Medicine

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Detection of benzodiazepine receptor occupancy in the human brain by positron emission tomography

Shinotoh

Iyo²,

Yamada

et al. 1989

Psychopharmacology

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Benzodiazepine receptor occupancy in the brain following oral administration of clonazepam (CZP) with a dose of 30 micrograms/kg in six healthy young men and a further dose of 50 micrograms/kg in one of the subjects was estimated by carbon-11 labeled Ro15-1788 and positron emission tomography (PET). The effects of CZP on the latency of auditory event-related potentials (P300) were also studied. Overall brain 11C uptake was depressed and the % inhibition of 11C uptake in the gray matter of the brain at 30 min after [11C]Ro15-1788 injection was 15.3-23.5% (mean, n = 6) following 30 micrograms/kg CZP when compared with that in the control experiment without any previous treatment. The 11C uptake in the cerebral cortex in the subject who received both doses decreased in a dose-related manner after 30 micrograms/kg and 50 micrograms/kg CZP. The P300 latency was prolonged significantly by 30 micrograms/kg CZP [31.6 +/- 16.3 ms (mean +/- SD, n = 6), P less than 0.05]. The P300 latency in the same subject was prolonged in a dose-related manner by 30 micrograms/kg and 50 micrograms/kg CZP. The technique using [11C]Ro15-1788 and PET permits comparison of the pharmacological effects with the percentage of receptor sites which benzodiazepines occupy in the human brain. P300 also seems to be useful to investigate the pharmacological effects of benzodiazepines.

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Performance Study of Whole-Body, Multislice Positron Computed Tomograph POSITOLOGICA-II

Cited by 11 publications

References 8 publications

D1 dopamine receptor binding in mood disorders measured by positron emission tomography

D1 dopamine receptor binding in mood disorders measured by positron emission tomography

Meßtechnik in der Emissions-Computertomographie

Detection of benzodiazepine receptor occupancy in the human brain by positron emission tomography

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