Perfusion abnormalities and decision making in cocaine dependence

Tucker, Karen A.; Potenza, Marc N.; Beauvais, John; Browndyke, Jeffrey N.; Gottschalk, Paola; Kosten, Thomas R.

doi:10.1016/j.biopsych.2004.06.031

Cited by 62 publications

(47 citation statements)

References 13 publications

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“…78 The evidence that many PD punders have dopaminergic psychosis further supports an impairment of cortical domains, 79 similar to cocaine and amphetamine addicts who have been shown to have a dysfunction of the frontal lobe. 80,81 Despite the hypothetical frontal dysfunction, cognitive decline is very rarely reported in PD punders and no study has specifically assessed the cognitive profile of these patients. However, a relative sparing of cognitive functions fits well with Braak's staging of progressive cortical involvement 82 and with the results of a magnetic resonance imaging study that suggested that damage to the mesial frontal region is linked with pathological collection in the absence of any cognitive dysfunction.…”

Section: Methods and Review Criteriamentioning

confidence: 99%

Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, nongoal oriented, repetitive activity. Men tend to repetitively tinker with technical equipment such as radio sets, clocks, watches and car engines, the parts of which may be analyzed, arranged, sorted and cataloged but rarely put back together. Women, in contrast, incessantly sort through their handbags, tidy continuously, brush their hair or polish their nails. Punders are normally aware of the inapposite and obtuse nature of the behavior; however, despite the consequent self-injury, they do not stop such behavior. The most common causes of punding are dopaminergic replacement therapy in patients affected by Parkinson's disease (PD) and cocaine and amphetamine use in addicts. The vast majority of information about punding comes from PD cases. A critical review of these cases shows that almost all afflicted patients (90%) were on treatment with drugs acting mainly on dopamine receptors D1 and D2, whereas only three cases were reported in association with selective D2 and D3 agonists. Epidemiological considerations and available data from animal models suggest that punding, drug-induced stereotypies, addiction and dyskinesias all share a common pathophysiological process. Punding may be related to plastic changes in the ventral and dorsal striatal structures, including the nucleus accumbens, and linked to psychomotor stimulation and reward mechanisms. Possible management guidelines are proposed.

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Section: Methods and Review Criteriamentioning

confidence: 99%

Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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“…These depressed rates of functional activity have been reported to persist for up to three months of abstinence (Volkow et al 1993), a finding that has been recently confirmed in our laboratory (Hanlon et al 2006). In addition, disruptions in cerebral perfusion have also been consistently observed in prefrontal brain regions (Tumeh et al 1990;Holman et al 1991;Weber et al 1993;Adinoff et al 2003;Tucker et al 2004). The majority of these studies, however, were conducted at rest when the subjects were lying quietly in the scanner.…”

Section: Neuroanatomical Substrates Of Cognitive Deficits Exhibited Bmentioning

confidence: 99%

Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys

Beveridge

Gill

Hanlon

et al. 2008

Phil. Trans. R. Soc. B

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Cocaine users display profound impairments in executive function. Of all the components of executive function, inhibition, or the ability to withhold responding, has been studied the most extensively and may be most impaired. Consistent with these deficits, evidence from imaging studies points to dysregulation in medial and ventromedial prefrontal cortices, areas activated during performance of inhibition tasks. Other aspects of executive function including updating, shifting and decision making are also deficient in cocaine users, and these deficits are paralleled by abnormalities in patterns of prefrontal cortical activation. The extent to which cocaine plays a role in these effects, however, is not certain, and cannot be determined solely on the basis of human studies. Investigations using a non-human primate model of increasing durations of cocaine exposure revealed that initially the effects of cocaine were restricted to ventromedial and orbital prefrontal cortices, but as exposure was extended the intensity and spatial extent of the effects on functional activity also expanded rostrally and laterally. Given the spatial overlap in prefrontal pathology between human and monkey studies, these longitudinal mapping studies in non-human primates provide a unique window of understanding into the dynamic neural changes that are occurring early in human cocaine abuse.

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“…Using a similar paradigm. Tucker et al 102 also found a significant correlation between Gambling Task performance and anterior cingulate regional cerebral blood flow (rCBF) changes in cocainedependent subjects. Interestingly, however, the relationship was in the opposite direction as that reported by Adinoff et al, 100 i.e., increased anterior cingulate rCBF was correlated with poorer Gambling Task performance.…”

Section: Decision Makingmentioning

confidence: 94%

“…[92][93][94][95][96][97][98][99] Other groups, however, have not observed differences between substance use disordered patients and controls in Gambling Task performance. [100][101][102] In general, patients in the positive studies were typically studied shortly following active use and endorsed more than one drug of abuse. In contrast, the negative studies assessed abstinent, cocaine-addicted subjects.…”

Section: Decision Makingmentioning

confidence: 99%

“…Differences between these two studies may be explained by the testing of recently using cocaine-addicted subjects (last use 4.6 ± 3.1 days prior to testing) in the Adinoff et al study 100 vs. at least two weeks abstinence in the Tucker et al study. 102 Using fMRI, Paulus et al 120 demonstrated a relationship between anterior cingulate and DLPFC (among other regions) activity and outcome predictability during a two-choice decision task. This group has also shown blunted activation of the DLPFC, as well as the OFC, in methamphelamine-addicted subjects during this same decision-making task.…”

Section: Decision Makingmentioning

confidence: 99%

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Impulsivity, Neural Deficits, and the Addictions

Adinoff

Rilling

Williams

et al. 2007

Journal of Addictive Diseases

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SUMMARYImpulsive behaviors are observed in a wide range of psychiatric disorders, including substance use, bipolar, attention-deficit hyperactivity, antisocial and borderline personality, gambling, and eating disorders. The shared phenotype of impulsivity is thought to significantly contribute to both the etiology and perpetuation of these disorders. In this review, we focus upon the relevance of impulsivity to the addictive disorders, particularly substance use disorders. First, the literature supporting the presence of impulsive behaviors prior to the onset of drug use and addiction is discussed. The relevance of impulsivity to relapse is then presented, with a focus on three distinct neurocognitive constructs: automaticity, response inhibition, and decision making. Automaticity is a quickly occurring relapse process resulting from the learned habits induced by persistent drug use. Addicted persons with response inhibition deficits are unable to suppress these previously reinforced behaviors. Decision-making deficits contribute to relapse through a poorly considered assessment of the consequences of drug use. The brain regions associated with each model of impulsive behavior are described, and relevant neurobiologic disruptions in addicted subjects are discussed in the context of their specific neurocognitive deficit(s). Descriptive confusions in the terminology and confounds inherent in the study of impulsivity are described. Empirical

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Perfusion abnormalities and decision making in cocaine dependence

Cited by 62 publications

References 13 publications

Insights into pathophysiology of punding reveal possible treatment strategies

Insights into pathophysiology of punding reveal possible treatment strategies

Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys

Impulsivity, Neural Deficits, and the Addictions

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