Perfusion-based functional magnetic resonance imaging with single-shot RARE and GRASE acquisitions

Crelier, Gérard; Hoge, Richard D.; Münger, P.; Pike, G. Bruce

doi:10.1002/(sici)1522-2594(199901)41:1<132::aid-mrm18>3.0.co;2-5

Cited by 33 publications

(19 citation statements)

References 14 publications

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“…Unfortunately, EPI is extremely sensitive to susceptibility artifacts, which results in spatial misregistration and signal voiding in the vicinity of magnetic field inhomogeneities. Several different data-recording strategies for FAIR ASL have been developed to overcome this limitation based on single-shot FSE imaging (11,12). However, these approaches have the disadvantage of significant blurring due to relatively long echo trains.…”

Section: Discussionmentioning

confidence: 99%

“…Single-shot fast spin-echo (FSE) approaches (e.g., RARE and HASTE) are hampered by strong blurring due to T2 decay during the acquisition of relatively long echo trains (15). The combined SE and gradient-echo (GRE) approach of GRASE suffers from complicated phase errors (11); however, a recent study reported that such errors can be reduced with the use of a single-shot three-dimensional approach (16). FAIR-FLASH perfusion imaging with repeated RF small-angle excitation can result in undesired saturation effects (13), and TurboFLASH imaging shows a markedly reduced signal yield compared to EPI (15).…”

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confidence: 99%

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FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Boss

Martirosian

Klose

et al. 2007

Magnetic Resonance Imaging

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Purpose:To estimate cerebral blood perfusion in areas of strong magnetic susceptibility changes with high spatial and temporal resolution using a flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling (ASL) method. Materials and Methods:We implemented an ASL method that is capable of imaging perfusion in areas of high magnetic susceptibility changes by combining a FAIR spin preparation with a true fast imaging in steady precession (TrueFISP) data acquisition strategy. A TrueFISP readout sequence was applied especially in regions with magnetic field inhomogeneities and compared with corresponding FAIR measurements obtained with a standard echo-planar imaging (EPI) readout. Quantitative perfusion images were obtained at 1.5 Tesla (1.5T) from eight healthy volunteers (24 -42 years old) and one patient (23 years old). FAIRTrueFISP perfusion images were compared with FAIR echoplanar images. T1 maps, which are necessary for quantitative perfusion estimation, were obtained with inversion recovery (IR) TrueFISP and IR EPI. Additionally, high-resolution perfusion measurements were performed on four volunteers at 3T. Results:The two ASL perfusion imaging modalities yielded comparable diagnostic image quality in brain areas with low susceptibility differences at 1.5T. Cerebral perfusion of gray matter (GM) areas was 105.7 Ϯ 5.2 mL/100 g/minute for FAIR-TrueFISP and 88.8 Ϯ 14.6 mL/100 g/minute for FAIR-EPI at 1.5T, and 70.4 Ϯ 7.1 mL/100 g/minute for FAIR-TrueFISP and 63.5 Ϯ 6.9 mL/100 g/minute for FAIR-EPI at 3.0T. Higher perfusion values at 1.5T were due to more pronounced partial-volume effects from fast moving spins at lower spatial resolution. The FAIR-TrueFISP sequence showed no significant distortions and markedly reduced signal void artifacts in areas of high susceptibility changes (e.g., near brain-bone transitions and close to metallic clips) compared to FAIR-EPI. At 3T, highly resolved FAIR-TrueFISP perfusion images were acquired with an in-plane resolution of up to 1.3 mm.Conclusion: FAIR-TrueFISP allows for assessment of cerebral perfusion in areas of critically high susceptibility changes with conventional ASL methods.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Boss

Martirosian

Klose

et al. 2007

Magnetic Resonance Imaging

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“…Instead, new imaging methods such as tailored RF pulses (Chen and Wyrwicz, 1999) or z shimming (Yang et al, 1997(Yang et al, , 1998 likely will be necessary to obtain reliable signal in these areas. It also has been suggested that use of spiral scanning could reduce susceptibility artifacts in the temporal lobe (Crelier et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility-Induced Loss of Signal: Comparing PET and fMRI on a Semantic Task

et al. 2000

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Functional magnetic resonance imaging (fMRI) has become a popular tool for investigations into the neural correlates of cognitive activity. One limitation of fMRI, however, is that it has difficulty imaging regions near tissue interfaces due to distortions from macroscopic susceptibility effects which become more severe at higher magnetic field strengths. This difficulty can be particularly problematic for language tasks that engage regions of the temporal lobes near the air-filled sinuses. This paper investigates susceptibility-induced signal loss in the temporal lobes and proposes that by defining a priori regions of interest and using the small-volume statistical correction of K. J. Worsley, S. Marrett, P. Neelin, A. C. Vandal, K. J. Friston, and A. C. Evans (1996, Hum. Brain Mapp. 4: 58 -83), activations in these areas can sometimes be detected by increasing the statistical power of the analysis. We conducted two experiments, one with PET and the other with fMRI, using almost identical semantic categorization paradigms and comparable methods of analysis. There were areas of overlap as well as differences between the PET and fMRI results. One anticipated difference was a lack of activation in two regions in the temporal lobe on initial analyses in the fMRI data set. With a specific region of interest, however, activation in one of the regions was detected. These experiments demonstrate three points: first, even for almost identical cognitive tasks such as those in this study, PET and fMRI may not produce identical results; second, differences between the two methods due to macroscopic susceptibility artifacts in fMRI can be overcome with appropriate statistical corrections, but only partially; and third, new data acquisition paradigms are necessary to fully deal with susceptibility-induced signal loss if the sensitivity of the fMRI experiment to temporal lobe activations is to be enhanced.

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“…Liu et al 97 accounted for this to a degree with the FAIR-HASTE technique, which minimizes susceptibility effects. Several other strategies for minimizing susceptibility artifact have been described, including GRASE, 3D fast spin echo-based (RARE) methods 5,43,98,99 and using spin-echo instead of gradient-echo echoplanar imaging. 100 These issues also apply to other clinical applications, especially evaluation of degenerative disorders such as Alzheimer's disease (AD) and perfusion fMRI (e.g., for memory).…”

Section: Epilepsymentioning

confidence: 99%

Clinical Neuroimaging Using Arterial Spin-Labeled Perfusion Magnetic Resonance Imaging

2007

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Summary:The two most common methods for measuring perfusion with MRI are based on dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL). Although clinical experience to date is much more extensive with DSC perfusion MRI, ASL methods offer several advantages. The primary advantages are that completely noninvasive absolute cerebral blood flow (CBF) measurements are possible with relative insensitivity to permeability, and that multiple repeated measurements can be obtained to evaluate one or more interventions or to perform perfusion-based functional MRI. ASL perfusion and perfusion-based functional MRI methods have been applied in many clinical settings, including acute and chronic cerebrovascular disease, CNS neoplasms, epilepsy, aging and development, neurodegenerative disorders, and neuropsychiatric diseases. Recent technical advances have improved the sensitivity of ASL perfusion MRI, and increasing use is expected in the coming years. The present review focuses on ASL perfusion MRI and applications in clinical neuroimaging.

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Perfusion-based functional magnetic resonance imaging with single-shot RARE and GRASE acquisitions

Cited by 33 publications

References 14 publications

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

FAIR‐TrueFISP imaging of cerebral perfusion in areas of high magnetic susceptibility differences at 1.5 and 3 Tesla

Susceptibility-Induced Loss of Signal: Comparing PET and fMRI on a Semantic Task

Clinical Neuroimaging Using Arterial Spin-Labeled Perfusion Magnetic Resonance Imaging

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