2024
DOI: 10.1101/2024.04.22.590587
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Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by64Cu-CTS PET Imaging

Friedrich Baark,
Aidan M. Michaels,
Edward C. T. Waters
et al.

Abstract: Background: Hypoxia is central to many cardiac pathologies, but clinically its presence can only be inferred by indirect biomarkers including hypoperfusion and energetic compromise. Imaging hypoxia directly could offer new opportunities for the diagnosis and sub-stratification of cardiovascular diseases. Objectives: To determine whether [64Cu]CuCTS Positron Emission Tomography (PET) can identify hypoxia in a murine model of cardiac hypertrophy. Methods: Male C57BL/6 mice underwent abdominal aortic constriction… Show more

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