Perfusion lung scanning in pulmonary hypertension

Murray, T; Te, Hilditch; Aa, Bolster; At, Elliott

doi:10.1097/00006231-199507000-00015

Cited by 2 publications

(1 citation statement)

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“…The V9/Q9 lung scan is a relatively inexpensive and widely available investigation that is recommended in the management and diagnosis of pulmonary hypertension to screen for CTEPH because of its higher sensitivity than computed tomography [4,5,25,26]. A normal or low-probability V9/Q9 lung scan effectively excludes CTEPH with a high sensitivity and specificity [4,5].…”

Section: Analysis Of Patients With Nonmatched Perfusion Defectsmentioning

confidence: 99%

Ventilation Perfusion Lung Scan In Pulmonary Veno-Occlusive Disease

Montani¹,

Seferian²,

Girerd³

et al. 2011

A60. Pulmonary Hypertension: Diagnosis

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Pulmonary veno-occlusive disease (PVOD), a rare form of pulmonary arterial hypertension (PAH), requires histological proof for definitive diagnosis; however, lung biopsy is not recommended in PAH. Recent conjoint European Respiratory Society/European Society of Cardiology guidelines suggest that nonmatched perfusion defects on ventilation/perfusion (V9/Q9) lung scanning in PAH patients may suggest PVOD. The aim of our study was to evaluate V9/Q9 lung scans in a large cohort of PVOD and idiopathic or heritable PAH patients.V9/Q9 lung scans from 70 patients with idiopathic or heritable PAH and 56 patients with confirmed or highly probable PVOD were reviewed in a double-blind manner.The vast majority of V9/Q9 lung scans were normal or without significant abnormalities in both groups. No differences in ventilation or perfusion lung scans were observed between PAH and PVOD patients (all p.0.05). Furthermore, no differences were observed between confirmed (n531) or highly probable PVOD (n525). Nonmatched perfusion defects were found in seven (10%) idiopathic PAH patients and four (7.1%) PVOD patients (p.0.05).Nonmatched perfusion defects were rarely seen in a large cohort of idiopathic or heritable PAH and PVOD patients. Future recommendations should be amended according to these results suggesting that V9/Q9 lung scanning is not useful in discriminating PVOD from idiopathic PAH.

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