Perfusion of subchondral bone marrow in knee osteoarthritis: A dynamic contrast-enhanced magnetic resonance imaging preliminary study

Budzik, Jean-François; Ding, J. C.; Norberciak, Laurène; Pascart, Tristan; Toumi, Hechmi; Verclytte, Sébastien; Coursier, Raphaël

doi:10.1016/j.ejrad.2016.12.023

Cited by 14 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Budzik et al recently showed that perfusion parameters were higher in OA bone compared to non-OA bone in knee OA [27]. They also showed a positive correlation with the WORMS scoring of BMLs.…”

Section: Discussionmentioning

confidence: 92%

Quantitative subchondral bone perfusion imaging in knee osteoarthritis using dynamic contrast enhanced MRI

Vries

Heijden

Verschueren

et al. 2020

Seminars in Arthritis and Rheumatism

View full text Add to dashboard Cite

Subchondral bone changes, characterized by increased bone turnover and vascularity, are believed to stimulate progression and pain in knee osteoarthritis (OA). The objective of this study was to evaluate the bone perfusion in knee OA using quantitative dynamic contrast enhanced MRI (DCE-MRI). Design: Unicompartmental knee OA patients were included and underwent 3 Tesla DCE-MRI and T2weighted MRI. Quantitative DCE-MRI analysis of Ktrans and Kep, representing perfusion parameters, was performed to evaluate differences between the most and least affected knee compartment. First, DCE-MRI parameter differences between epimetaphyseal and subchondral bone in both femur and tibia were assessed. Second, DCE-MRI parameters in subchondral bone marrow lesions (BMLs) were compared to surrounding subchondral bone without BMLs. Results: Twenty-three patients were analyzed. Median Ktrans and Kep in epimetaphyseal bone were significantly higher (p < 0.05) in the most affected (Ktrans: 0.014; Kep: 0.054 min À1 ) compared to least affected (Ktrans: 0.010; Kep: 0.016 min À1 ) compartment. For subchondral bone, DCE-MRI parameters were significantly higher (p < 0.05) in the most affected (Ktrans: 0.019; Kep: 0.091 min À1 ) compared to least affected (Ktrans: 0.014; Kep: 0.058 min À1 ) compartment as well. Subchondral BMLs detected on fat-saturated T2weighted images were present in all patients. Median Ktrans (0.091 vs 0.000 min À1 ) and Kep (0.258 vs 0.000 min À1 ) were significantly higher within subchondral BMLs compared to surrounding subchondral bone without BMLs (p < 0.001). Conclusions: Increased perfusion parameters in epimetaphyseal bone, subchondral bone and BMLs are observed in unicompartmental knee OA. BMLs likely account for most of the effect of the higher bone perfusion in knee OA.

show abstract

Section: Discussionmentioning

confidence: 92%

Quantitative subchondral bone perfusion imaging in knee osteoarthritis using dynamic contrast enhanced MRI

Vries

Heijden

Verschueren

et al. 2020

Seminars in Arthritis and Rheumatism

View full text Add to dashboard Cite

show abstract

“…It included end-stage OA with multiple pathological changes, particularly bone marrow lesions that could interfere with perfusion measurements and selected small ROIs. The study did not use fat suppression so that perfusion kinetics of normal bone could not be measured 9 . By enabling fat suppression in the DCE-MRI sequence, our study was able to measure perfusion kinetics and compare them in normal and OA bone.…”

Section: Discussionmentioning

confidence: 99%

Subchondral bone circulation in osteoarthritis of the human knee

Aaron

Racine

Voisinet

et al. 2018

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…The search yielded 135 articles (Supplementary Appendix) of which 113 were excluded by title, abstract, or full-text review for the following reasons: study of a medical treatment, surgical study, or procedure (23), bone density or mechanical properties of bone or cartilage (19), specific patient or animal subgroup (12), posttraumatic osteoarthritis (6), or receptors, hormones, or biological markers (6); interventional study (14); test of imaging technique (7); histological or morphometric study (5); review article (14) or letter (1); non-English language (6). Twenty-two articles were eligible, of which 13 [6][7][8][9][10][11][12][13][14][15][16][17][18] were cited because they had the highest relevance to inform the proposed clinical model (Fig. 2).…”

Section: Literature Searchmentioning

confidence: 99%

“…Budzik et al found that subchondral bone marrow (SCBM) vascularization was greatest in the compartment most affected by OA, both in tibia and femur, with a positive correlation between the extent of bone marrow edema and SCBM perfusion [11]. Lee et al hypothesized that changes in perfusion patterns in subchondral bone bear a functional relationship to bone remodeling and cartilage degeneration [6].…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

View full text Add to dashboard Cite

Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal BMI, and absence of knee pain at baseline. Both patients had Kellgren–Lawrence grade 1 in the affected knee at the time of twisting knee injuries leading to osteoarthritis diagnoses at age 50 (patient 1) and 51 (patient 2). Patient 1 developed a chronic right knee effusion, and progressed to Kellgren–Lawrence grade 3 bilaterally by the time she had a right total knee replacement at age 58. Patient 2 had subchondral fractures of the right knee with transient effusion, which healed after 1 year of partial weight-bearing with crutches and subsequent daily use of knee sleeves. Patient 2 had Kellgren–Lawrence grade 0 bilaterally upon surveillance imaging at age 58. The terms “osteoarthritis and knee and diagnostic imaging and subchondral bone and pathophysiology” were searched in the PubMed database to identify original research articles to inform a clinical model consistent with the patients’ outcomes. A fluid model of osteoarthritis was the best explanatory model for the discordant clinical trajectories of the age-matched siblings. Patient recommendations are presented based on these findings.

show abstract

Perfusion of subchondral bone marrow in knee osteoarthritis: A dynamic contrast-enhanced magnetic resonance imaging preliminary study

Cited by 14 publications

References 20 publications

Quantitative subchondral bone perfusion imaging in knee osteoarthritis using dynamic contrast enhanced MRI

Quantitative subchondral bone perfusion imaging in knee osteoarthritis using dynamic contrast enhanced MRI

Subchondral bone circulation in osteoarthritis of the human knee

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Contact Info

Product

Resources

About