Peri‐ and intraventricular cerebral sonography in second‐ and third‐trimester high‐risk fetuses: a comparison with neonatal ultrasound and relation to neurological development

Gelder-Hasker, M. R. van; Wezel‐Meijler, Gerda van; Groot, Laila de; Geijn, H.P. van; Vries, J.I.P. de

doi:10.1002/uog.179

Cited by 31 publications

(27 citation statements)

References 41 publications

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“…The first examined periventricular densities in 26 fetuses exposed to uteroplacental insufficiency before and after birth, with neurological follow-up until 24 months. 5 Grade-1A periventricular echodensities (white matter as bright or almost as bright as the choroid plexus) was seen in four fetuses. These densities were also seen within 24 h after birth.…”

Section: Transient Changes or Permanent Damagementioning

confidence: 92%

“…5,6 It has been demonstrated that the localization of the HII damage is age-dependent and widespread in neonates 2 :…”

Section: Age-related Predilection Areasmentioning

confidence: 99%

“…20 In a second group of fetuses exposed to uteroplacental insufficiency, five out of 26 had unilateral density in the thalamus that disappeared after birth. 5 This was explained as a normal finding caused by reflection of the thalamocaudate notch or by a transient phenomenon of unknown origin. Two of these fetuses, however, developed PVL after birth with neurological abnormalities.…”

Section: Transient Changes or Permanent Damagementioning

confidence: 99%

“…It is possible to obtain axial, coronal, and sagittal planes; anomalies should be examined in two directions to distinguish between abnormality and artefacts. 4,5 Both can achieve three-dimensional imaging. The diagnostic possibilities are same in fetuses with suspected brain anomalies.…”

Section: Similarities Between Us and Mrimentioning

confidence: 99%

“…deposition of other minerals, myelinization). A classification system for PVL and bleeding, which applies equally before and after birth, has been used for US, 5 whereas the systems differ for MRI. One scoring system for MRI evaluation after birth, covering eight aspects through the brain, looks attractive.…”

Section: Similarities Between Us and Mrimentioning

confidence: 99%

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Fetal brain monitoring: Future applications

Vries

2006

Seminars in Fetal and Neonatal Medicine

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Summary Future application of fetal brain monitoring is explored by selecting and analysing articles for information on types of brain damage that can be monitored, where in the brain this can be done, how long after the risk exposure, and with what method of investigation.A limited number ofdmainlydcase histories reported that early (cell death and oedema) and late (gliosis) effects of brain damage can be demonstrated before birth with multiplanar ultrasound and magnetic resonance imaging, and that hypoxic ischaemic injury or infection can induce local or widespread brain injury, occurring as transient or longer-lasting changes in age-related predilection areas for which normal features are known.The antenatal role of risk factors inducing abnormal brain development can be studied longitudinally with ultrasound and magnetic resonance imaging. A multidisciplinary approach will facilitate the introduction of various techniques with adequate know-how of underlying processes, to evaluate the predictive value on neurological outcome and prevent premature introduction into clinical application. ª

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Section: Transient Changes or Permanent Damagementioning

confidence: 92%

“…5,6 It has been demonstrated that the localization of the HII damage is age-dependent and widespread in neonates 2 :…”

Section: Age-related Predilection Areasmentioning

confidence: 99%

Section: Transient Changes or Permanent Damagementioning

confidence: 99%

Section: Similarities Between Us and Mrimentioning

confidence: 99%

Section: Similarities Between Us and Mrimentioning

confidence: 99%

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Fetal brain monitoring: Future applications

Vries

2006

Seminars in Fetal and Neonatal Medicine

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Inflammation in white matter: Clinical and pathophysiological aspects

Pleasure

Soulika

Singh

et al. 2006

Ment. Retard. Dev. Disabil. Res. Rev.

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While the central nervous system (CNS) is generally thought of as an immunopriviledged site, immune-mediated CNS white matter damage can occur in both the perinatal period and in adults, and can result in severe and persistent neurological deficits. Periventricular leukomalacia (PVL) is an inflammatory white matter disease of premature infants that frequently results in cerebral palsy (CP). Clinical and experimental studies show that both hypoxic/ischemic and innate immune mechanisms contribute to the destruction of immature oligodendroglia and of axons in the deep cerebral white matter in PVL. No data are yet available as to whether there is any genetic predisposition to PVL or to its neurological sequelae. Multiple sclerosis (MS) is an inflammatory white matter disease that often begins in young adulthood, causes multifocal destruction of mature oligodendroglia and of axons, and eventually leads to substantial cumulative neurological disability. Certain genetic polymorphisms contribute to susceptibility to MS, and adaptive immune responses to myelin-associated self antigens, or to exogenous antigens that mimic these self antigens, play a central role in the pathophysiology of this disease.

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