Peri‐Implantitis versus Periodontitis: Functional Differences Indicated by Transcriptome Profiling

Abstract

Taken together, our results suggest considering periimplantitis and periodontitis as disease entities with shared as well as with distinct features, which should be reflected on the therapeutical as well as on the scientific level.

Periodontally compromised vs. periodontally healthy patients and dental implants: A systematic review and meta-analysis

“…9 Having said this, a recent investigation demonstrated significantly different mRNA signatures between periodontitis and peri-implantitis. 10 Therefore, a pertinent question in relation to implant therapy in patients susceptible to periodontitis is whether these patients may also show an elevated risk for periimplant tissue destruction. Thus, the aim of this metaanalysis is to compare the survival rate of dental implants, postoperative infection, and marginal bone loss of dental implants inserted in PCPs and in periodontally healthy patients (PHPs).…”

Repurposing Toremifene for Treatment of Oral Bacterial Infections

“…Exponential-phase cells of S. mutans were incubated with 1ϫ and 4ϫ the MIC of toremifene or chlorhexidine at 37°C under shaking conditions (see Table S1 in the supplemental material). At periodic intervals, aliquots taken from the samples were serially diluted in MgSO 4 and subsequently plated on TSB agar. After incubation for 2 days as 37°C, cell viability was determined by CFU counting.…”

“…The Gram-negative anaerobic bacterium Porphyromonas gingivalis and the Gram-positive bacterium Streptococcus mutans are two important causative agents of oral infections. P. gingivalis is frequently involved in chronic inflammatory diseases, such as periodontitis and peri-implantitis, resulting in the destruction of soft and hard tissues surrounding teeth and dental implants, respectively (3,4). S. mutans is known to be the main pathogenic agent of dental caries, a chronic disease characterized by irreversible destruction of the tooth (5).…”

Biologic Markers of Failing Implants

“…Accordingly, microbial biofilm on peri-implant surfaces induces an inflammatory response in susceptible hosts; this response involves features shared with and distinct from features of periodontitis. 40,41 The classic inflammatory peptides and proteins that respond to bacterial inflammation are cytokines and chemokines produced by T lymphocytes and monocytes/macrophages. In addition, many nonspecific markers of inflammation make up the inflammatory milieu.…”