Peri-operative changes in serum immune markers after trauma: A systematic review

Easton, Ruth; Balogh, Zsolt J.

doi:10.1016/j.injury.2013.12.002

Cited by 53 publications

(42 citation statements)

References 76 publications

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“…However, some studies still find certain drawbacks to CRP as a predictor of stress-related complications [9, 22], including less accuracy in some patients. However, CAR is based on circulating levels of two acute phase proteins, CRP and albumin, which are also associated with inflammation from surgical trauma [19].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of the postoperative ratio of C-reactive protein to albumin for complications after colorectal surgery

Cao

Wang

et al. 2017

World J Surg Onc

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BackgroundThe ratio of C-reactive protein to albumin, as a novel inflammation-based prognostic score, is associated with outcomes in cancer and septic patients. The diagnostic accuracy of the CRP/albumin ratio has not been assessed in colorectal surgery for postoperative complications.MethodsA total of 359 patients undergoing major colorectal surgery between 2012 and 2015 were eligible for this study. Uni- and multivariate analyses were performed to identify risk factors for postoperative complications. Receiver operating characteristic curves were developed to examine the cutoff values and diagnostic accuracy of the CRP/albumin ratio and postoperative CRP levels.ResultsAmong all the patients, 139 (38.7%) were reported to have postoperative complications. The CRP/albumin ratio was an independent risk factor for complications (OR 4.413; 95% CI 2.463–7.906; P < 0.001), and the cutoff value was 2.2, which had a higher area under the curve compared to CRP on postoperative day 3 (AUC 0.779 vs 0.756). The CRP/albumin ratio also had a higher positive predictive value than CRP levels on postoperative day 3. Patients with CRP/albumin ≥2.2 suffered more postoperative complications (60.8% vs 18.6%, P < 0.001), longer postoperative stays (10 (4–71) vs 7 (3–78) days, P < 0.001), and increased surgical site infections (SSIs) (21.1% vs 4.8%, P < 0.001) than those with CRP/albumin <2.2.ConclusionsThe ratio of C-reactive protein to albumin could help to identify patients who have a high probability of postoperative complications, and the ratio has higher diagnostic accuracy than C-reactive protein alone for postoperative complications in colorectal surgery.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of the postoperative ratio of C-reactive protein to albumin for complications after colorectal surgery

Cao

Wang

et al. 2017

World J Surg Onc

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“…Moreover, pathophysiologic aspects, such as metabolic and inflammatory reactions, and insulin resistance are gaining increasing importance and might be valuable parameters to identify major interventions. [6,[13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

A Novel Approach to Major Surgery: Tracking Its Pathophysiologic Footprints

et al. 2015

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“…The proinflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8 and the antiinflammatory IL-10 have been considered important markers of inflammatory activity [10]. Therefore we focused on these.…”

Section: Discussionmentioning

confidence: 99%

Activation of Markers of Inflammation, Coagulation and Fibrinolysis in Musculoskeletal Trauma

Reikerås

Borgen

2014

PLoS ONE

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BackgroundTraumatic injury induces changes in mediators of inflammation and coagulation, but the pivotal roles of inflammation and coagulation has not been precisely clarified. Therefore we have studied markers of inflammation and coagulation after a standardized musculoskeletal trauma like total hip replacement surgery.MethodsWe allocated 21 patients aged 50 to 84 years who underwent total hip replacement surgery. Releases of TNF-α, IL-1β, IL-6, IL-8 and IL-10 and protrombin fragment F1.2 and plasmin-antiplasmin complex (PAP) were examined during surgery and up 6 days postoperatively, and systemic releases were compared to pre-operative values. Surgery induced significant increments in serum levels of IL-6 at 6 hours and at 1 day after surgery and in levels of IL-8 at 6 hours after surgery. There were no significant changes in serum levels of TNF-α, IL-1β or IL-10. There were significant increments in blood levels of F1.2 and PAP up to 6 days postoperatively with highest levels at 6 hours after surgery. There were only week correlations between IL-6 and IL-8 and F1.2 and PAP.ConclusionMajor musculoskeletal surgery causes changes of the inflammatory, coagulatory and fibrinolytic cascades in stable patients, but with no correlations between inflammation and coagulation and fibrinolysis.

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Peri-operative changes in serum immune markers after trauma: A systematic review

Cited by 53 publications

References 76 publications

Diagnostic accuracy of the postoperative ratio of C-reactive protein to albumin for complications after colorectal surgery

Diagnostic accuracy of the postoperative ratio of C-reactive protein to albumin for complications after colorectal surgery

A Novel Approach to Major Surgery: Tracking Its Pathophysiologic Footprints

Activation of Markers of Inflammation, Coagulation and Fibrinolysis in Musculoskeletal Trauma

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