Peri-Operative Nasal Eradication Therapy Prevents<i>Staphylococcus aureus</i>Surgical Site Infections in Aortoiliac Surgery

Langenberg, Jasper C M; Kluytmans, Jan; Mulder, Paul; Romme, Jannie; Ho, Gwan H.; Laan, Lijckle van der

doi:10.1089/sur.2018.029

Cited by 8 publications

(7 citation statements)

References 27 publications

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“…55 Of note, S. aureus eradication in this setting was associated with a decrease in S.aureus related SSIs but not in the SSIs due to other bacteria, which may be explained by the competing behaviour of bacteria causing SSI. 55…”

Section: Logistics and Peri-operative Carementioning

confidence: 75%

“…The incidence of S. aureus SSI was significantly lower in patients who were screened positive and who were treated for methicillin resistant S. aureus (MRSA) nasal carriage compared with patients negative for nasal MRSA carriage (0% vs. 13.6%). 55 In addition, both 30 day mortality reintervention rates were significantly lower in the treated group (1.3% vs. 13.6%). 55 Of note, S. aureus eradication in this setting was associated with a decrease in S.aureus related SSIs but not in the SSIs due to other bacteria, which may be explained by the competing behaviour of bacteria causing SSI.…”

Section: Logistics and Peri-operative Carementioning

confidence: 83%

“…55 In addition, both 30 day mortality reintervention rates were significantly lower in the treated group (1.3% vs. 13.6%). 55 Of note, S. aureus eradication in this setting was associated with a decrease in S.aureus related SSIs but not in the SSIs due to other bacteria, which may be explained by the competing behaviour of bacteria causing SSI. 55…”

Section: Logistics and Peri-operative Carementioning

confidence: 83%

See 2 more Smart Citations

Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections

Chakfé

Diener

Lejay

et al. 2020

European Journal of Vascular and Endovascular Surgery

370

322

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DEDICATIONAfter studying medicine at Hanover Medical School and philosophy and social psychology at the Leibniz University Hanover, Omke E. Teebken joined the Christian Albrechts University in Kiel at the end of the 1990s as a research fellow at the Clinic for Cardiovascular Surgery headed by Professor Dr Axel Haverich, whom Omke E. Teebken later followed back to Hanover.In Hanover, besides working as a clinician, Omke E.Teebken was particularly active scientifically, contributing to the establishment of the then newly founded Leibniz Laboratories for Biotechnology and Artificial Organs (LEBAO). His work focused on regenerative medicine and tissue engineering, and subsequently he wrote his habilitation thesis in in this field. After basic training in cardiac surgery, he specialised clinically in vascular surgery and played a pioneering role in the development of this field. Before being appointed director of the Clinic for Vascular Surgery e Endovascular Surgery at the Peine Clinic in 2016, Omke E. Teebken headed the Vascular Surgery e Endovascular Surgery Division of the Department of Cardiothoracic, Thoracic, Transplantation and Vascular Surgery at Hanover Medical School. Professor Teebken was a highly appreciated, committed, and competent colleague and teacher.On 8 April 2019, Professor Teebken passed away after a short and severe illness. He was member and author of the ESVS guideline writing committee, an esteemed colleague, and friend.We will always honor his memory.

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Section: Logistics and Peri-operative Carementioning

confidence: 75%

Section: Logistics and Peri-operative Carementioning

confidence: 83%

Section: Logistics and Peri-operative Carementioning

confidence: 83%

See 1 more Smart Citation

Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections

Chakfé

Diener

Lejay

et al. 2020

European Journal of Vascular and Endovascular Surgery

370

322

View full text Add to dashboard Cite

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“…It is commonly present as part of the normal flora of the skin and nose, with screening studies reporting carriage rates of around 20%. 146 An association between nasal carriage of Staphylococcus aureus and the development of SSI has been recognised. 147 Consequently, identification of nasal carriage before surgery and treatment of positives with a 5-day course of mupirocin and chlorhexidine soap has been associated with a significant reduction in rate of SSI caused by Staphylococcus aureus.…”

Section: Nasal Decolonisationmentioning

confidence: 99%

Surgical site infection: Prevention and management across health-care sectors

et al. 2020

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Aims, objectives and scope of document 4 Structure and content 4 2. Methodology and terminology 5 3. Epidemiology of surgical site infection 6 Surgical site infection: background 6 Signs and symptoms of SSI 7 Source of microorganisms related to SSI 10 Type of surgery and risk of SSI 10 Adjusting rates of SSI for variation in case-mix 12 Patient-related factors and the risk of SSI 12 Involving patients with diagnostics 13 Conclusion 13

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“…Of the various sites reported, the nose is considered to be an important reservoir in humans and nasal colonization has been reported to be an independent risk factor for SSIs (7)(8)(9). To reduce the incidence of S. aureus infections, nasal application of topical mupirocin has been widely reported in the literature (10,11). In one of the earliest randomized controlled trials (RCTs) on surgical patients, Bode et al (12) reported a significantly reduced incidence of SSIs in S. aureus carriers with the use of pre-operative nasal mupirocin and chlorhexidine soap.…”

Section: Introductionmentioning

confidence: 99%

Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis

Wang

2021

Exp Ther Med

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The purpose of the present study was to provide a systematic literature review and pool evidence on the efficacy of mupirocin-based decolonization protocol in reducing surgical-site infections (SSIs) in patients undergoing cardiothoracic (CT) surgery based on their Staphylococcus ( S .) aureus carrier state. The PubMed, Embase, Ovid, BioMed Central, Cochrane Central Register of Controlled Trials and Google Scholar databases were searched for studies comparing mupirocin-based decolonization with controls for reducing SSIs in patients following CT surgery. Studies were grouped based on the targeted population of intervention, i.e. carriers or all patients. A total of 17 studies were included. Of these, 8 studies used targeted mupirocin-based decolonization, while universal decolonization was performed in 9 studies. The results were conflicting for studies performing targeted decolonization and it was not possible to perform a meta-analysis due to non-homogenous studies. Pooled analysis of 34,859 patients indicated that universal mupirocin-based decolonization significantly reduced the risk of all SSIs [risk ratio (RR): 0.54; 95% CI: 0.40,0.75; I 2 =73.35%]. The intervention significantly reduced the risk of superficial SSIs (RR: 0.37; 95% CI: 0.25,0.55; I 2 =0%) but not of deep SSIs (RR: 0.45; 95% CI: 0.19,1.09; I 2 =80.67%). The results indicated a significantly reduced risk of S. aureus SSIs (SA-SSIs) with mupirocin-based decolonization (RR: 0.44; 95% CI: 0.32,0.61; I 2 =0%) but not for methicillin-resistant S. aureus (MRSA-SSIs; RR: 0.25; 95% CI: 0.05,1.28; I 2 =79.07%). Evidence on the role of targeted mupirocin-based decolonization to reduce SSIs after CT surgery was non-coherent and inconclusive. Analysis of low-quality retrospective studies suggested that universal mupirocin-based decolonization may reduce all SSIs, superficial SSIs and SA-SSIs, but not deep SSIs or MRSA-SSIs in patients after CT surgery.

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Peri-Operative Nasal Eradication Therapy PreventsStaphylococcus aureusSurgical Site Infections in Aortoiliac Surgery

Abstract: We conclude that S. aureus nasal screening and eradication with mupirocin and chlorhexidine reduces S. aureus SSI and its complications after aortoiliac surgery.

Cited by 8 publications

References 27 publications

Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections

Editor's Choice – European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections

Surgical site infection: Prevention and management across health-care sectors

Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis

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