2019
DOI: 10.1007/s00167-019-05700-2
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Peri-operative steroids reduce pain, inflammatory response and hospitalisation length following knee arthroplasty without increased risk of acute complications: a meta-analysis

Abstract: PurposeThere is no consensus regarding the risks and benefits of peri‐operative steroid supplementation in total knee arthroplasty (TKA). The aim of this meta‐analysis is to compare TKA protocols implemented with or without steroids in terms of pain, inflammatory response, hospitalisation length, and complications. MethodsA systematic literature search was performed on July 2019 in PubMed, Medline, Embase, Web of Science, Cochrane library, and the grey literature for a meta‐analysis of RCTs comparing peri‐oper… Show more

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Cited by 6 publications
(4 citation statements)
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“…Similar results were reported in articles focusing on IV administration of corticosteroids. Strong evidence supports the use of a single or multiple doses of intravenous dexamethasone to reduce postoperative pain, opioid consumption, nausea, and vomiting after primary TJA ( 5 , 6 ); In addition, IV corticosteroids are effective in decreasing ROM limitation ( 6 ) and are not associated with increased risks of complications ( 5 ). Compared to periarticular injections, IV administration of corticosteroids yields better results, especially in controlling postoperative nausea and vomiting, as the antiemetic effect is related to systemic absorption and plasma concentration of dexamethasone ( 19 ).…”
Section: Discussionmentioning
confidence: 99%
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“…Similar results were reported in articles focusing on IV administration of corticosteroids. Strong evidence supports the use of a single or multiple doses of intravenous dexamethasone to reduce postoperative pain, opioid consumption, nausea, and vomiting after primary TJA ( 5 , 6 ); In addition, IV corticosteroids are effective in decreasing ROM limitation ( 6 ) and are not associated with increased risks of complications ( 5 ). Compared to periarticular injections, IV administration of corticosteroids yields better results, especially in controlling postoperative nausea and vomiting, as the antiemetic effect is related to systemic absorption and plasma concentration of dexamethasone ( 19 ).…”
Section: Discussionmentioning
confidence: 99%
“…By adding steroids to perioperative drug protocols, which is called steroid supplementation, either through intravenous (IV) administration ( 5 ) or periarticular infiltration (PAI) ( 5 ), pain, opioid use, nausea and vomiting, limited range of motion, and inflammatory markers can be reduced without increasing short- and mid-term complications ( 6 ).…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, we can take corresponding measures to reduce the level of postoperative inflammatory response. Adding steroids to peri-operative drug protocols is effective in reducing postoperative CRP levels [ 21 ], which may potentially reduce the occurrence of postoperative fever.…”
Section: Discussionmentioning
confidence: 99%
“…administreres som en del af en multimodal tilgang sammen med paracetamol, NSAID og lokal infiltrationsanalgesi (LIA) [13][14][15].…”
Section: Ugeskrift For Laeger Ugeskrift For Laegerunclassified