Peri-Partum Cardiac Failure

Davidson, Neil

doi:10.1016/s0140-6736(78)91770-1

Cited by 38 publications

(34 citation statements)

References 10 publications

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“…6 There is wide geographical variation in the incidence of PCM, ranging from a low incidence of 1 in 15 000 deliveries in the United States, 52 an intermediate frequency of 1 in 1000 deliveries in South Africa, 48 and a high frequency of 1 in 100 deliveries in Zaria, Nigeria. 53 The cause of PCM is unknown. Several pathogenetic factors have been suggested, including poor socioeconomic status, unrecognized hypertension in pregnancy, excessive dietary salt intake, selenium deficiency, high parity, advanced maternal age, twin pregnancy, prolonged lactation, and viral myocarditis.…”

Section: Peripartum Cardiomyopathymentioning

confidence: 99%

Epidemiology and Etiology of Cardiomyopathy in Africa

Sliwa

Damasceno²,

Mayosi³

2005

Circulation

226

144

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Background— Cardiomyopathy, an often irreversible form of heart muscle disease that is associated with a dismal outcome, is endemic in Africa. The primary objective of this review was to summarize the current state of knowledge on the epidemiology and etiology of cardiomyopathy in people living in Africa and to identify new avenues for research. Methods and Results— We searched MEDLINE (January 1, 1966, through February 12, 2005) and reference lists of articles for relevant references. Unlike other parts of the world in which cardiomyopathy is rare, dilated cardiomyopathy is a major cause of heart failure throughout Africa. Similarly, peripartum cardiomyopathy is ubiquitous on the continent, with an incidence ranging from 1 in 100 to 1 in 1000 deliveries. There is an apparent marked regional variation in the pathogenesis of dilated cardiomyopathy and peripartum cardiomyopathy, underlining the heterogeneity of causative factors in these conditions. By contrast, endomyocardial fibrosis is restricted to the tropical regions of East, Central, and West Africa. Although the pathogenesis of endomyocardial fibrosis is not fully understood, it seems that the conditioning factors are geography and diet, the triggering factor may be an as yet unidentified infective agent, and the perpetuating factor is eosinophilia. Although epidemiological studies are lacking, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy seem to have characteristics similar to those of other populations elsewhere in the world. Conclusions— There is a need for large-scale epidemiological studies of the incidence, prevalence, determinants, and outcome of cardiomyopathy in Africa to inform strategies for the treatment and prevention of heart muscle disease on the continent.

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Section: Peripartum Cardiomyopathymentioning

confidence: 99%

Epidemiology and Etiology of Cardiomyopathy in Africa

Sliwa

Damasceno²,

Mayosi³

2005

Circulation

226

144

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“…16, 18, 20. 36, 37], Davidson and Parry [46] and Fillmore and Parry [47] reported an additional 397 patients, of which 3 died from cerebral embolism. These patients were not included in this summary since their prob lems appear to be a result of volume overload due to a high sodium intake with heat stress.…”

Section: Discussionmentioning

confidence: 99%

Peripartum Cardiomyopathy and Stroke

Dyken

Biller

1994

Cerebrovasc Dis

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In the United States, peripartum cardiomyopathy (PC) is an uncommon form of dilated cardiomyopathy, which, when associated with stroke, results in a high mortality rate. The estimated incidence of PC at the University of Iowa Hospitals and Clinics from 1/1/1976 to 7/1/1993 averaged only 1 out of every 8,135 deliveries. Of the total 5 cases diagnosed, only 1 presented with neurologic manifestations. Through the use of echocardiography, cine-computerized tomography and magnetic resonance imaging, a large left ventricular mural thrombus in a diffusely hypokinetic heart was found. Newer cardiac imaging techniques are improving our ability to diagnose the cause of stroke in the younger population, including women in the peripartum period, allowing early institution of appropriate medical treatment and hopefully improving prognosis.

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“…Haiti and South Africa with an incidence between 1:100 to 1:1 000, (3)(4)(5)(6)(7) is one of the reasons why numerous previous studies on PPCM relied on case reports, small numbers of patients or a review of medical records. One option was even a survey among 15 000 members of the American College of Cardiology by mail (8) in an effort to obtain basic information that totaled 123 patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical profi ling of patients with peripartum cardiomyopathy and its value for translational research

Förster

Sliwa

ker-Kleiner

2017

SAHJ

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Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery despite optimal medical therapy. Experimental data suggested that enhanced oxidative stress promotes the proteolytical processing of the lactation hormone prolactin into a biologically active derivative, the 16kDa prolactin, which appears to be a major cause for PPCM. We observed increased oxLDL levels in a subset of these PPCM patients, indicative of oxidative stress, enhanced Cathepsin D activity and substantial levels of the cleaved 16kDa form of prolactin. We therefore propose that the excessive generation of 16kDa prolactin mediates PPCM in humans and suggest that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM.

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Peri-Partum Cardiac Failure

Cited by 38 publications

References 10 publications

Epidemiology and Etiology of Cardiomyopathy in Africa

Epidemiology and Etiology of Cardiomyopathy in Africa

Peripartum Cardiomyopathy and Stroke

Clinical profi ling of patients with peripartum cardiomyopathy and its value for translational research

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