Peri-pubertal high caffeine exposure increases ovarian estradiol production in immature rats

Kwak, Yoojin; Choi, Hyeonhae; Bae, Jaeman; Choi, Yun Young; Roh, Jaesook

doi:10.1016/j.reprotox.2017.01.007

Cited by 15 publications

(12 citation statements)

References 38 publications

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“…Another hypothesis is that caffeine might interfere directly with ovarian physiology. In a previous study, female rats fed caffeine showed increased ovarian production of estradiol and delayed vaginal opening (27). Furthermore, several studies evaluating women showed the consumption of coffee and other caffeinated beverages was linked to a longer delay before becoming pregnant.…”

Section: Discussionmentioning

confidence: 88%

Effects of Caffeine on Egg Quality and Performance of Laying Hens

et al. 2020

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This study's objective was to determine the effects of caffeine intake at various levels, incorporated in the layers' food, on performance and egg quality of hens. A total of 576 hens, aged 56 weeks, were used. The layers were fed rations containing 0 (control), 150, 300, or 450 ppm of caffeine for 12 weeks. During the experimental period, performance parameters (weight, feed consumption, and livability) and egg production and quality (weight, Haugh unit, percentages of yolk, albumen and eggshell, yolk color, eggshell thickness, and resistance, and calcium and phosphorus eggshell contents) were evaluated. The highest concentration of caffeine in the diet (450 ppm) promoted a significant increase in the mortality of hens (1.45% per week) compared to controls (0.23%). There was a reduction in feed consumption by hens, decreased egg production, and reduced eggshell thickness and percentage, with the increase of caffeine. The egg yolk percentage was increased, and the eggshell percentage was reduced in the groups treated with 300 and 450 ppm of caffeine. Furthermore, reduced eggshell thickness was found in all groups that received caffeine. However, it was found that 150 ppm of caffeine in the food did not cause significant changes in most egg production and quality parameters. In summary, caffeine consumption by laying hens increased mortality rate and promoted deleterious effects on chicken production and egg quality at concentrations of 300 and 450 ppm.

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Section: Discussionmentioning

confidence: 88%

Effects of Caffeine on Egg Quality and Performance of Laying Hens

et al. 2020

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“…Uterine weight increases as puberty progresses in rodents and this increase is associated with E2 levels. However, studies have reported that increased E2 levels my cause a decrease or no change in uterine weight of immature rats (25,26,27). These unexpected results were explained by altered sensitivity of the estrogen receptors in the uterus due to high E2 concentrations or due to the substance used in the experiment (27).…”

Section: Discussionmentioning

confidence: 98%

“…However, studies have reported that increased E2 levels my cause a decrease or no change in uterine weight of immature rats (25,26,27). These unexpected results were explained by altered sensitivity of the estrogen receptors in the uterus due to high E2 concentrations or due to the substance used in the experiment (27). In this present study, absolute and relative uterine weight was increased in the HD group and both LH and E2 concentrations were higher in the HD group compared to the CT and LD groups.…”

Section: Discussionmentioning

confidence: 99%

Effects of 5-Hydroxymethylfurfural on Pubertal Development of Female Wistar Rats

Elmaoğulları

Kadan

Anadol

et al. 2020

Jcrpe

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Objective: 5-Hydroxymethylfurfural (HMF) is formed when sugars are heated in the presence of amino acids. HMF is naturally present in many foods. To investigate the toxic effects of HMF on the reproductive system of peripubertal rats. Methods: In the study, 24 immature female Wistar rat were divided into three groups: control (CT) fed with no HMF; low dose fed with 750 mg/kg/day of HMF and high dose (HD) groups fed with 1500 mg/kg/day of HMF. All groups received these diets for three weeks from postnatal day (PND) 21. The vaginal opening (VO) was monitored daily and euthanasia occurred on PND 44. Gonadotropin, estradiol (E2), progesterone and anti-Müllerian hormone (AMH) concentrations were measured. Reproductive organ weights and ovarian follicle counts were compared. Results: The HD HMF group had earlier VO. Higher mean luteinising hormone (2.9±1.2 vs 1.3±0.3 mIU/mL) and mean E2 (34.7±8.8 vs 21.2±3.9 pg/mL) and lower mean AMH (2.7±0.5 vs 4.7±0.7 ng/mL) concentrations were found in the HD compared to the CT group. The HD group also had increased number of secondary atrophic follicles. Conclusion: These results indicate that peripubertal exposure to HMF at HD result in precocious puberty and decreased AMH levels in female Wistar rats. Abstract 79 J Clin Res Pediatr Endocrinol 2020;12(1): [79][80][81][82][83][84][85] What is already known on this topic? What this study adds?5-Hydroxymethylfurfural (HMF) is an organic compound that is present at high amounts in processed foods and foodstuffs as a result of heating, roasting, frying and toasting. Data on potential genotoxic, mutagenic, carcinogenic, DNA-damaging, organotoxic and enzyme inhibitory effects of HMF and its metabolites are conflicting. To the best of our knowledge there are no published data about the effects of HMF on pubertal development. This is the first study of the effects of HMF on pubertal development. The results indicate that peripubertal exposure to HMF in high doses result in precocious puberty and decreased anti-Müllerian hormone levels in female Wistar rats.

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“…There is much concern about the impact on human health of environmental chemicals that are able to interfere with the endocrine system, particularly those that affect steroidogenesis. Previously, we showed that caffeine acts as an endocrine disruptor of the reproductive system in both immature male and female rats owing to its effects on sex hormone levels [16,17]. In addition, some of the effects of caffeine on gonadal sex steroid production in immature rats are sex specific [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, we showed that caffeine acts as an endocrine disruptor of the reproductive system in both immature male and female rats owing to its effects on sex hormone levels [16,17]. In addition, some of the effects of caffeine on gonadal sex steroid production in immature rats are sex specific [16,17]. In addition, sex differences in susceptibility to caffeine during both gestation and lactation have been reported in the offspring of rats [18].…”

Section: Introductionmentioning

confidence: 99%

The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats

Ryu

Roh

2019

Nutrients

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The consumption of high levels of dietary caffeine has increased in children and adolescents. Human and animal studies have shown that chronic intake of high doses of caffeine affects serum glucocorticoid levels. Given that glucocorticoids play a role in peripubertal organ growth and development, chronic high doses of caffeine during puberty might impair maturation of the adrenal glands. To evaluate any effects of caffeine exposure on growing adrenal glands, 22-day-old male (n = 30) and female Sprague Dawley rats (n = 30) were divided into three groups (n = 10/group); group 1 received tap water (control) and groups 2 and 3 received water containing 120 and 180 mg/kg/day caffeine, respectively, via gavage for 4 weeks. At the end of the experiment, adrenal glands were weighed and processed for histological analysis. Relative adrenal weights increased in both groups of caffeine-fed males and females, whereas absolute weights were decreased in the females. In the female caffeine-fed groups the adrenal cortical areas resembled irregularly arranged cords and the medullary area was significantly increased, whereas no such effects were seen in the male rats. Our results indicate that the harmful effects of caffeine on the adrenal glands of immature rats differ between females and males. Although female rats seemed to be more susceptible to damage based on the changes in the microarchitecture of the adrenal glands, caffeine affected corticosterone production in both female and male rats. In addition, increased basal adrenocorticotropic hormone levels in caffeine-fed groups may reflect decreased cortical function. Therefore, caffeine may induce an endocrine imbalance that disturbs the establishment of the hypothalamo–pituitary adrenal axis during puberty, thereby leading to abnormal stress responses.

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Peri-pubertal high caffeine exposure increases ovarian estradiol production in immature rats

Cited by 15 publications

References 38 publications

Effects of Caffeine on Egg Quality and Performance of Laying Hens

Effects of Caffeine on Egg Quality and Performance of Laying Hens

Effects of 5-Hydroxymethylfurfural on Pubertal Development of Female Wistar Rats

The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats

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