Periampullary carcinoma in a patient with agenesis of dorsal pancreas

Kapoor, Abhimanyu; Singh, R. K.

doi:10.1093/jscr/2011.9.4

Cited by 11 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathological result showed that our ADP case was associated with chronic suppurative pancreatitis, with moderate hyperplasia in focal ductal epithelium of the pancreas, which was actually considered to be the precancerous lesion of the pancreas. Previous studies have confirmed that ADP patients may combine with chronic pancreatitis and periampullary tumors including pancreatic adenocarcinoma, neuroendocrine tumor, solid pseudopapillary tumor of the pancreas, and cholangiocarcinoma [18,28–31] . Cholangiocarcinoma and solid pseudopapillary tumor of the pancreas were described to be combined with Chinese ADP patients in our review as well [8,10]…”

Section: Discussionsupporting

confidence: 74%

Agenesis of the dorsal pancreas with chronic suppurative pancreatitis

Xia

Jiang

et al. 2021

Medicine

View full text Add to dashboard Cite

Rationale: Agenesis of the dorsal pancreas (ADP) is a rare congenital anomaly of the pancreas. ADP is associated with some other medical problems such as diabetes mellitus, abdominal pain/bloating, pancreatitis, pancreatic neuroendocrine tumor and so on. In this study, we present a case of ADP with chronic suppurative pancreatitis, summarize the clinical characteristics of the reported cases in China and review the correlative literature. Patient concerns: A 51-year-old Chinese man, with a history of impaired fasting glucose, presented with jaundice, pruritus and dark urine. Laboratory analysis showed abnormal liver function and elevated carbohydrate antigen 19-9. Diagnoses: Contrast-enhanced computed tomography demonstrated a mass located at the head of pancreas and complete absence of the body and tail of pancreas. Endoscopic retrograde cholangiopancreatography demonstrated an eccentric malignant stricture about 1.6cm of distal common bile duct. Interventions: The patient underwent pancreaticoduodenectomy because of the suspicion of pancreatic tumor. The postoperative pathological result was chronic suppurative pancreatitis, with moderate hyperplasia in focal ductal epithelium. Outcomes: A long-term follow-up shows that the patient is asymptomatic with well-controlled diabetes mellitus and pancreatic exocrine insufficiency. Lessons: ADP is a quite rare congenital malformation of the pancreas with poorly-understood pathogenesis. The diagnosis of ADP depends on the imaging examination. The therapeutic strategy varies from person to person due to the different accompanying conditions.

show abstract

Section: Discussionsupporting

confidence: 74%

Agenesis of the dorsal pancreas with chronic suppurative pancreatitis

Xia

Jiang

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…The mechanism of tumorigenesis in ADP patients is unclear, but chronic pancreatitis caused by the ADP itself could be one of the risk factors for neoplasia [2]. Thus, the association of tumorigenesis with ADP indicates that every ADP patient should be observed with a focus on the early detection of pancreatic neoplasia [4,5,22,23]. According to literature reports and our own study, the clinical features of SPTs in patients with ADP are similar to those observed in patients without ADP [12,13,21,24,25].…”

Section: Discussionsupporting

confidence: 53%

Pancreatic Head Sparing Surgery for Solid Pseudopapillary Tumor in Patients with Agenesis of the Dorsal Pancreas

Shyr

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: This study aimed to clarify the feasibility and justification of pancreatic head sparing (PHS) enucleation for patients with agenesis of the dorsal pancreas (ADP) associated with a solid pseudopapillary tumor (SPT).Methods: Data of the SPT patients with and without ADP, including clinical presentations, surgical options, and surgical and survival outcomes, were recruited for comparison.Results: A total of 31 patients with SPTs were included, 3 of whom displayed ADP and underwent PHS enucleation. Surgical complications were comparable between the groups. Overall, the 5-year and 10-year disease-free survival rates were 100% and 90%, respectively. The 20-year and 25-year overall survival rates were 100% and 66.7%, respectively. Only one patient (3.2%) developed tumor recurrence 7.3 years after pancreatectomy for an SPT with lymph node involvement, and the patient survived 24.5 years after the initial operation. No tumor recurrence occurred in any patient with ADP after PHS enucleation.Conclusion: The association between tumorigenesis and ADP suggests that every congenital ADP patient should be observed for the early detection of pancreatic neoplasia. PHS enucleation seems to be feasible and justifiable for SPT patients with ADP in terms of surgical and survival outcomes, and this approach could be recommended to avoid pancreatic insufficiency.

show abstract

“…Solid pseudopapillary tumor in patients with agenesis of the dorsal pancreas reported in the world SPT of the pancreas with ADP is extremely rare, with only two cases having been reported in the literature prior to this study, 21 Herein, we describe another three cases, making a total of five reported thus far. More than 10 ADP cases have been associated with pancreatic neoplasia, although only about 100 occurrences of ADP are recorded in the literature, [1][2][3][4][5][6] The mechanism of tumorigenesis in ADP patients is unclear, but chronic pancreatitis caused by the ADP itself could be one of the risk factors for neoplasia, 2 Thus, the association of tumorigenesis with ADP indicates that every ADP patient should be observed with a focus on the early detection of pancreatic neoplasia, 4,5,22,23 According to literature reports and our own study, the clinical features of SPTs in patients with ADP are similar to those observed in patients without ADP, 12,13,21,24,25 This tumor usually occurs in young females, with less than 10% of cases reported in males. 11,26 Our series also agrees with previous research in terms of the most common localization of SPTs 27 and the most frequent symptom 10,12,14,21,25 being the pancreas head and epigastric pain, respectively.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic head sparing surgery for solid pseudopapillary tumor in patients with agenesis of the dorsal pancreas

Shyr

Wang

Chen

et al. 2022

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

Background: This study aimed to clarify the feasibility and justification of pancreatic head sparing (PHS) enucleation for patients with agenesis of the dorsal pancreas (ADP) associated with a solid pseudopapillary tumor (SPT). Methods: Data of the SPT patients with and without ADP, including clinical presentations, surgical options, and surgical and survival outcomes, were recruited for comparison. Results: A total of 31 patients with SPTs were included, three of whom displayed ADP and underwent PHS enucleation. Surgical complications were comparable between the groups. Overall, the 5- and 10-year disease-free survival rates were 100% and 90%, respectively. The 20- and 25-year overall survival rates were 100% and 66.7%, respectively. Only one patient (3.2%) developed tumor recurrence 7.3 years after pancreatectomy for an SPT with lymph node involvement, and the patient survived 24.5 years after the initial operation. No tumor recurrence occurred in any patient with ADP after PHS enucleation. Conclusion: PHS enucleation seems to be feasible and justifiable for SPT patients with ADP in terms of surgical and survival outcomes, and this approach could be recommended to avoid pancreatic insufficiency.

show abstract

Periampullary carcinoma in a patient with agenesis of dorsal pancreas

Abstract: Agenesis of dorsal pancreas is a rare developmental anomaly. We here report a case of agenesis of dorsal pancreas in a patient of periampullary carcinoma and highlight its implications on the management.

Cited by 11 publications

References 9 publications

Agenesis of the dorsal pancreas with chronic suppurative pancreatitis

Agenesis of the dorsal pancreas with chronic suppurative pancreatitis

Pancreatic Head Sparing Surgery for Solid Pseudopapillary Tumor in Patients with Agenesis of the Dorsal Pancreas

Pancreatic head sparing surgery for solid pseudopapillary tumor in patients with agenesis of the dorsal pancreas

Contact Info

Product

Resources

About