Perianal bowen's disease and anal intraepithelial neoplasia

Cleary, Robert K.; Schaldenbrand, John D.; Fowler, Jennifer; Schuler, J. M.; Lampman, Richard M.

doi:10.1007/bf02237107

Cited by 80 publications

(58 citation statements)

References 39 publications

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“…Trata-se de uma lesão pré-cancerosa, neoplasia intra-epitelial ou carcinoma in situ. Pode evoluir para o carcinoma epidermoide invasivo em aproximadamente 2-6% dos casos (2,13) .…”

Section: Discussão E Conclusãounclassified

“…As alterações genéticas possivelmente encontradas e utilizadas como indicadores de uma maior tendência invasiva das dermatoses pré-malignas, (DB, Eritroplasia de Queyrat e Papulose Bowenóide) (5) são as mutações no gene supressor tumoral p53, em até 80% dos casos (13) e a expressão do antígeno nuclear Ki-67. Ainda são necessárias mais pesquisas para definir o valor prognóstico da presença destas alterações quanto ao potencial de recorrência e invasão tumoral (10) .…”

Section: Discussão E Conclusãounclassified

“…Dentre as patologias a serem consideradas no diagnóstico diferencial da DB devemos citar: Doença de Paget, carcinoma basocelular, ceratose seborréica, líquen simples crônico, líquen escleroatrófico, condiloma acuminado, melanoma, eczemas, extensão descendente de carcinoma de reto (9) , psoríase (11) e papulose bowenóide (13 ) .…”

Section: Introductionunclassified

“…O tratamento de escolha da DB é a ressecção cirúrgica com margens de segurança (1,4,8,10,11,13) , muitas vezes sendo necessários enxertos ou avanços de retalhos para cobrir o defeito deixado na pele (3,4,13,14) . Porém diversas outras opções terapêuticas são ocasionalmente utilizadas no manejo da doença, tais como terapia fotodinâmica (2,9,10,13,14 ) , laser de argônio, crioterapia (2,8,9,10,13) e quimioterapia com 5-fluorouracil tópico com ou sem irradiação local (2,8,11,13) .…”

Section: Introductionunclassified

“…Porém diversas outras opções terapêuticas são ocasionalmente utilizadas no manejo da doença, tais como terapia fotodinâmica (2,9,10,13,14 ) , laser de argônio, crioterapia (2,8,9,10,13) e quimioterapia com 5-fluorouracil tópico com ou sem irradiação local (2,8,11,13) .…”

Section: Introductionunclassified

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Doença de bowen perianal - diagnóstico e tratamento: relato de caso

Netto

Yamane

Castro

et al. 2009

Rev bras. colo-proctol.

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“…Trata-se de uma lesão pré-cancerosa, neoplasia intra-epitelial ou carcinoma in situ. Pode evoluir para o carcinoma epidermoide invasivo em aproximadamente 2-6% dos casos (2,13) .…”

Section: Discussão E Conclusãounclassified

Section: Introductionunclassified

See 3 more Smart Citations

Doença de bowen perianal - diagnóstico e tratamento: relato de caso

Netto

Yamane

Castro

et al. 2009

Rev bras. colo-proctol.

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Anal intraepithelial neoplasia

Abbasakoor

Boulos

2005

British Journal of Surgery

113

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The aetiology of AIN is intricately linked with human papilloma viruses. The pathological processes involved in the progression of AIN are becoming clearer but the natural history, particularly the rate of progression to invasive cancer, remains unknown. There is no standard management for AIN and this is mainly due to difficulties in both diagnosis and treatment. A variety of treatment options have been tried with varying success. Surgery is associated with significant recurrence, particularly in HIV-positive patients. Non surgical approaches with imiquimod, photodynamic therapy and vaccination are appealing, and further work is required. Long-term follow-up of these patients is essential until the natural history of AIN becomes clearer.

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Environmental scan of anal cancer screening practices: worldwide survey results

et al. 2014

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Anal squamous cell carcinoma is rare in the general population but certain populations, such as persons with HIV, are at increased risk. High-risk populations can be screened for anal cancer using strategies similar to those used for cervical cancer. However, little is known about the use of such screening practices across jurisdictions. Data were collected using an online survey. Health care professionals currently providing anal cancer screening services were invited to complete the survey via email and/or fax. Information was collected on populations screened, services and treatments offered, and personnel. Over 300 invitations were sent; 82 providers from 80 clinics around the world completed the survey. Fourteen clinics have each examined more than 1000 patients. Over a third of clinics do not restrict access to screening; in the rest, eligibility is most commonly based on HIV status and abnormal anal cytology results. Fifty-three percent of clinics require abnormal anal cytology prior to performing high-resolution anoscopy (HRA) in asymptomatic patients. Almost all clinics offer both anal cytology and HRA. Internal high-grade anal intraepithelial neoplasia (AIN) is most often treated with infrared coagulation (61%), whereas external high-grade AIN is most commonly treated with imiquimod (49%). Most procedures are performed by physicians, followed by nurse practitioners. Our study is the first description of global anal cancer screening practices. Our findings may be used to inform practice and health policy in jurisdictions considering anal cancer screening.

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Perianal bowen's disease and anal intraepithelial neoplasia

Cited by 80 publications

References 39 publications

Doença de bowen perianal - diagnóstico e tratamento: relato de caso

Doença de bowen perianal - diagnóstico e tratamento: relato de caso

Anal intraepithelial neoplasia

Environmental scan of anal cancer screening practices: worldwide survey results

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