Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study

Segura-Sampedro, Juan José; Jiménez-Giménez, Carla; Jané‐Salas, Enric; Cabanillas-Balsera, Daniel; Martín-González, Jénifer; Segura-Egea, Juan José; López‐López, José

doi:10.1111/iej.13747

Cited by 10 publications

(22 citation statements)

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“…A prevalence study reported similar prevalence of RFT with RPL in patients with UC (31%) or Crohn's disease (21%; p > .05; Poyato‐Borrego et al, 2021), and a first age‐ and gender‐matched case–control study found no significant differences between IBD patients and controls (Poyato‐Borrego et al, 2020). However, the results of a recent age‐ and sex‐matched case–control study (Segura‐Sampedro et al, 2022), reported that the percentage of IBD patients with at least one RFT with AP was 54%, compared to only 11% in the control group (OR = 9.60; 95% CI = 2.35–39.35; p = .001). The authors concluded that dentists should monitor the evolution of periapical lesions of root treated teeth in patients with UC or Crohn's disease.…”

Section: Resultsmentioning

confidence: 97%

“…The authors suggested that BMs could be used in the treatment of AP. At this respect, two case–control studies have found a higher prevalence of AP in patients with IBD (Poyato‐Borrego et al, 2020; Segura‐Sampedro et al, 2022) compared to control subjects. On the contrary, a cross‐sectional study reported no association between the prevalence of AP and IBD (Piras et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

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Impact of systemic health on treatment outcomes in endodontics

et al. 2022

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Background:The healing of periapical lesions after root canal treatment (RCT) is not the result of the curative action of the treatment. The process of healing begins with inflammation, and is resolved by the clearance of the immunogen that induces the immune response. Then, the periapical tissue itself carries out the healing of the periapical lesion, by repair or by a combination of repair and regeneration, depending on the host's reparative response working properly. The ultimate objective of RCT is to achieve wound healing by removing the source of bacterial antigens and toxins, allowing chronic inflammatory tissue to become reparative tissue. Some systemic conditions increase the susceptibility of the host to infection or impair the tissue reparative response, maintaining the inflammatory process and periapical bone resorption after RCT. This can cause the failure of RCT and even the need for extraction of the affected tooth. Objective:To analyse the scientific literature on the possible influence of systemic conditions on the treatment outcomes in endodontics, as well as to discuss the biological mechanisms that may be involved. Methods:The search was carried out in PubMed, SCOPUS and EMBASE. The inclusion criteria established were original scientific articles reporting data about some systemic condition in relation to treatment outcomes in endodontics, including clinical studies and studies carried out in animal models.Results: Systemic factors (age, nutrition, stress, hormones, smoking habits), and systemic diseases, such as diabetes, cardiovascular diseases, osteoporosis, HIV infection, inflammatory bowel disease, and others, can influence or interfere in the repair of periapical tissues after RCT.Discussion: Some of these systemic diseases can alter bone turnover and fibroblast function, preventing or delaying periapical wound healing. Others can alter the microvasculature, reducing nutrients and oxygen supply to periapical tissues. As a result, these systemic conditions can decrease the success rate of RCT and provoke incomplete wound healing (typically granulomatous tissue formation) in the periapical region.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Impact of systemic health on treatment outcomes in endodontics

et al. 2022

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“…From Segura‐Sampedro et al (2022)—‘An additional 28 subjects, eight men and 20 women (58.6 ± 11.9 years), who agreed and met the same inclusion/exclusion criteria, healthy and who reported no history of inflammatory bowel disease (IBD), were matched for age and sex, constituting the “control group”. Controls were recruited from patients in the same city and health district, seeking for the first time routine dental care (not emergency care) in the same hospital between 2018 and 2021’.…”

Section: Process Involved In Developing the Preferred Reporting Items...mentioning

confidence: 99%

“…From Segura‐Sampedro et al (2022)—‘Twenty‐three patients with inflammatory bowel disease (IBD) (82%) had at least one tooth with radiolucent periapical lesion (RPLs), whilst in the control group (CG) 17 subjects (61%) showed radiographic signs of apical periodontitis (AP) [Odds ratio (OR) = 2.98; 95% confidence interval (CI) = 0.87–10.17; p = .076)]. The number of subjects with one or more root filled teeth (RFT) in the CG was 14 (50.0%) whilst in the study group (SG) they were 22 (78.6%; OR = 3.67; 95% CI = 1.14–11.79; p = .026).…”

Section: Process Involved In Developing the Preferred Reporting Items...mentioning

confidence: 99%

PROBE 2023 guidelines for reporting observational studies in endodontics: Explanation and elaboration

Nagendrababu¹,

Duncan

Fouad

et al. 2023

Int Endodontic J

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Observational studies play a critical role in evaluating the prevalence and incidence of conditions or diseases in populations as well as in defining the benefits and potential hazards of health‐related interventions. There are currently no reporting guidelines for observational studies in the field of Endodontics. The Preferred Reporting Items for study Designs in Endodontology (PRIDE) team has developed and published new reporting guidelines for observational‐based studies called the ‘Preferred Reporting items for OBservational studies in Endodontics (PROBE) 2023’ guidelines. The PROBE 2023 guidelines were developed exclusively for the speciality of Endodontics by integrating and adapting the ‘STrengthening the Reporting of OBservational studies in Epidemiology (STROBE)’ checklist and the ‘Clinical and Laboratory Images in Publications (CLIP)’ principles. The recommendations of the Guidance for Developers of Health Research Reporting Guidelines were adhered to throughout the process of developing the guidelines. The purpose of this document is to serve as a guide for authors by providing an explanation for each of the items in the PROBE 2023 checklist along with relevant examples from the literature. The document also offers advice to authors on how they can address each item in their manuscript before submission to a journal. The PROBE 2023 checklist is freely accessible and downloadable from the PRIDE website (http://pride-endodonticguidelines.org/probe/).

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“…Failure of the endodontic treatment can potentially be used for predicting the onset of apical periodontitis [ 136 ]. Despite differences in their origins, periodontitis and endodontic diseases demonstrate remarkable similarities such as a common microbiota that contains gram-negative anaerobic bacteria and elevated concentrations of systemic cytokines and inflammatory markers in association with both diseases [ 137 ]. Therefore, it has been proposed that endodontic lesions are more likely to develop cardiovascular disorders in a similar fashion to that found for periodontitis [ 138 ].…”

Section: Relation Between Tooth Conditions and Strokementioning

confidence: 99%

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

Shahi

Farhoudi

Dizaj

et al. 2022

JCM

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One of the primary causes of disability and mortality in the adult population worldwide is stroke. A person’s general health is significantly impacted by their oral and dental health. People who have poor oral health are more susceptible to conditions such as stroke. Stroke risk has long been linked to oral and dental conditions. The risk of stroke and its cost impact on the healthcare systems appear to be significantly reduced as a result of the decline in the incidence and prevalence of oral and dental illnesses. Hypothetically, better management of oral hygiene and dental health lead to reduced stroke risk. To the authors’ best knowledge, for the first time, the potential link between dental health and stroke were cross-examined. The most typical stroke symptoms, oral and dental illnesses linked to stroke, and the role of oral healthcare professionals in stroke prevention are revealed. The potential mediating processes and subsequent long-term cognitive and functional neurological outcomes are based on the available literature. It must be noted that periodontal diseases and tooth loss are two common oral health measures. Lack of knowledge on the effects of poor oral health on systemic health together with limited access to primary medical or dental care are considered to be partially responsible for the elevated risk of stroke. Concrete evidence confirming the associations between oral inflammatory conditions and stroke in large cohort prospective studies, stratifying association between oral disease severity and stroke risk and disease effects on stroke survival will be desirable. In terms of clinical pathology, a predictive model of stroke as a function of oral health status, and biomarkers of systemic inflammation could be useful for both cardiologists and dentists.

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Periapical and endodontic status of patients with inflammatory bowel disease: Age‐ and sex‐matched case–control study

Cited by 10 publications

References 74 publications

Impact of systemic health on treatment outcomes in endodontics

Impact of systemic health on treatment outcomes in endodontics

PROBE 2023 guidelines for reporting observational studies in endodontics: Explanation and elaboration

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

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