Peribiliary Cysts Associated with Severe Liver Disease: A Previously Unrecognized Tumor in a Lion (<i>Panthera Leo</i>)

Yu, Chi Ho; Kim, Kyoo Tae; Hwang, Du Na; Yhee, Ji Young; Moon, Chang Taek; Hur, Tai Young; Sur, Jung-Hyang

doi:10.1177/104063870701900617

Cited by 10 publications

(16 citation statements)

References 8 publications

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“…Na literatura, há apenas um relato da referida lesão nesta espécie, associada à doença hepática e responsável pela morte do animal (Yu et al 2007). No presente caso, a lesão observada no fígado era acentuada e comprometia grande parte do parênquima hepático, no entanto, não foram observados sinais clínicos associados aos cistos peribiliares e a morte ocorreu por outra causa.…”

Section: Discussionunclassified

“…Na prática clínica essa doença é pouco reconhecida (Nakanuma 2001). Não se conhece a patogenia exata para o surgimento dos cistos peribiliares, mas acredita-se que possam resultar da dilatação cística das glândulas peribiliares que circundam os grandes ductos biliares intra-hepáti-cos ou, talvez, serem congênitos (Yu et al 2007).…”

Section: Discussionunclassified

“…O primeiro diagnóstico diferencial são os cistadenomas biliares (Yu et al 2007). Estes ocorrem no parênquima hepático, diferente dos cistos peribiliares que se localizam do hilo hepático e nos grandes tratos portais.…”

Section: Discussionunclassified

“…Em Medicina Veterinária, cistos peribiliares são raramente descritos. Há relatos dessa lesão em fígados de suínos sadios, encontradas durante inspeção de abatedouro (Komine et al 2007, Komine et al 2008) e associada à letargia, emagrecimento progressivo e morte de um leão (Yu et al 2007). Este relato tem como objetivo descrever um caso de cistos peribiliares hepáticos em um leão-africano.…”

Section: Introductionunclassified

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Cistos peribiliares em leão-africano (Panthera leo)

Lucena

Fighera²,

Barros³

2011

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 31(2): 165-168, fevereiro 2011 RESUMO.-São descritos os achados macroscópicos e histopatológicos de cistos peribiliares em uma fêmea adulta de leão-africano (Panthera leo). Macroscopicamente, todos os lobos hepáticos continham numerosos cistos preenchidos por líquido translúcido. Histologicamente, os cistos estavam localizados no hilo hepático e nos tratos portais. Os cistos eram revestidos internamente por epitélio simples, constituído por células colunares ou cuboidais e não mucinosas, de acordo com avaliação para ácido periódico de Schiff/azul alciano. Na imuno-histiquímica, todas as células desse epitélio foram positivas para citoceratina. O leão morreu de complicações relacionadas a um carcinoma pulmonar e não foram observadas alterações clínicas associadas à lesão hepática, comprovando que cistos peribiliares em leões também ocorrem não associados a sinais clínicos.

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Section: Discussionunclassified

Section: Introductionunclassified

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Cistos peribiliares em leão-africano (Panthera leo)

Lucena

Fighera²,

Barros³

2011

Pesq. Vet. Bras.

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“…2,11,15,29 Gallbladder adenocarcinomas and hepatocellular carcinoma have been reported in lions. 19,20 In domestic animals, iron and copper accumulation have been linked to hepatic disease.…”

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Hepatic Lesions in 90 Captive Nondomestic Felids Presented for Autopsy

et al. 2014

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Hepatic lesions in nondomestic felids are poorly characterized. The purpose of this study was to evaluate hepatic lesions in 90 captive, nondomestic felids including tigers, cougars, and lions. Hepatic lesions were histologically characterized as vacuolar change (lipidosis or glycogenosis), biliary cysts, biliary hyperplasia, hepatitis, necrosis, neoplasia, fibrosis, veno-occlusive disease, cholestasis, hematoma, congestion, or hemorrhage. Stepwise logistic regression analyses were performed for vacuolar change, benign biliary lesions, hepatitis, lipogranulomas, extramedullary hematopoiesis, and hepatic stellate cell hypertrophy and hyperplasia, with species as the outcome variable. Ninety cats met the inclusion criteria. Seventy livers (78%) contained 1 or more lesions. Hepatocellular vacuolar change (41/90 [46%]) was the most common lesion overall. Extramedullary hematopoiesis, lipogranulomas, and hepatic stellate cell hyperplasia were also common. One snow leopard had veno-occlusive disease. Tigers were more likely than other felids to have no significant hepatic histologic lesions (odds ratio [OR], 12.687; P ¼ .002), and lions were more likely to have biliary cysts (OR, 5.97; P ¼ .021). Six animals (7%) died of hepatic disease: cholangiocellular carcinoma (n ¼ 2) and 1 each of hepatic lipidosis, hepatocellular necrosis, pyogranulomatous hepatitis, and suppurative cholecystitis. Hepatocellular iron and copper accumulations were present in 72 of 90 (80%) and 10 of 90 (11%) sections, respectively. Sinusoidal fibrosis was common (74/90 [82%]) and primarily centrilobular (65/74 [88%]). Hepatocellular iron, copper, and fibrosis were not significantly associated with hepatic lesions. Primary hepatic disease was not a common cause of death in nondomestic felids in this study.

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Multiple cyst formation in the liver and kidneys of a lion (Panthera leo): a case of polycystic kidney disease?

Gerhauser¹,

Philipp

Distl

et al. 2009

Eur J Wildl Res

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The present report describes the case of a 19-yearold male lion (Panthera leo) with polycystic lesions in liver and kidney. The animal suffered from inappetence and progressing hind limb weakness and was euthanized due to poor prognosis. Necropsy revealed multiple large, cystic cavities in the liver and numerous cysts in the renal cortex. Hepatic and renal cysts were lined by a flattened or cuboidal single-layered epithelium and derived from hepatic bile ducts and renal tubular structures, respectively, as confirmed by immunohistochemistry for the detection of different cytokeratins and carcinoembryonic antigen. Furthermore, a marked bile duct proliferation and fibrosis was found in the portal areas. Occasionally, renal cysts contained variable amounts of partly mineralized proteinaceous material, detached epithelial cells, and cellular debris. Additional findings included a moderate suppurative bronchopneumonia and other minor age-related degenerative changes. A mutation screen of exon 29 of the PKD1 gene did not reveal causative mutations like in domestic cats. This is the first report of polycystic kidney disease (PKD)-like lesions in a lion. The features of these lesions are similar to those of the adultonset form of PKD in Persian cats.

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Peribiliary Cysts Associated with Severe Liver Disease: A Previously Unrecognized Tumor in a Lion (Panthera Leo)

Cited by 10 publications

References 8 publications

Cistos peribiliares em leão-africano (Panthera leo)

Cistos peribiliares em leão-africano (Panthera leo)

Hepatic Lesions in 90 Captive Nondomestic Felids Presented for Autopsy

Multiple cyst formation in the liver and kidneys of a lion (Panthera leo): a case of polycystic kidney disease?

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