Pericardial and thoracic peri-aortic adipose tissues contribute to systemic inflammation and calcified coronary atherosclerosis independent of body fat composition, anthropometric measures and traditional cardiovascular risks

Yun, Chun‐Ho; Lin, Tzu-Chao; Wu, Yih‐Jer; Liu, Chuan-Chuan; Kuo, Jen‐Yuan; Yeh, Hung‐I; Yang, Fei-Shih; Chen, Su-Chiu; Hou, Charles Jia‐Yin; Bezerra, Hiram G.; Hung, Chung‐Lieh; Cury, Ricardo C.

doi:10.1016/j.ejrad.2011.01.035

Cited by 66 publications

(92 citation statements)

References 27 publications

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“…2,5 Consistent with previous publications, this present study demonstrated that patients with coronary atherosclerosis had significantly larger EAT volume. 7,15 However, the present study was first to demonstrate an inverse relationship between EAT volume and myocardial contractile function that is independent of CAD.…”

Section: Epicardial Adipose Tissue and Coronary Atherosclerosismentioning

confidence: 99%

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Epicardial Adipose Tissue Volume and Left Ventricular Myocardial Function Using 3-Dimensional Speckle Tracking Echocardiography

Goo

Roche

et al. 2016

Canadian Journal of Cardiology

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SUMMARYCoronary artery disease (CAD) and obesity are both independently associated with impaired myocardial systolic function. Epicardial adipose tissue (EAT) volume is another marker of visceral adiposity, and is associated with CAD. The association between EAT and myocardial systolic dysfunction versus other measures of obesity is unknown. This study showed that EAT volume is independently associated with myocardial systolic dysfunction, and may play a significant role in pathophysiology of diabetic, obesity and metabolic heart diseases.

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Section: Epicardial Adipose Tissue and Coronary Atherosclerosismentioning

confidence: 99%

“…15,16 Mediastinal fat and pericardial fat (outside the visceral pericardium and on the external surface of the parietal pericardium) were excluded.…”

Section: Epicardial Adipose Tissue Quantificationmentioning

confidence: 99%

Epicardial Adipose Tissue Volume and Left Ventricular Myocardial Function Using 3-Dimensional Speckle Tracking Echocardiography

Goo

Roche

et al. 2016

Canadian Journal of Cardiology

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“…CVD including coronary artery disease (CAD) and stroke account for 80% of all deaths in diabetic patients (5). There is evidence that abnormal lipid profile of excessive visceral fat tissue is linked with increased systemic inflammation, diabetes mellitus (DM) and CVD (6)(7)(8). Epicardial adipose tissue (EAT) is one of the visceral fat depots found in the body (9,10).…”

Section: Introductionmentioning

confidence: 99%

Epicardial Fat Thickness and its Association with Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus

2015

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“…There is growing evidence that excessive visceral adipose tissue (VAT) (including visceral abdominal, pericardial, and thoracic periaortic adipose tissue (TAT)) is linked to abnormal lipid profiles, enhanced systemic inflammation, diabetes mellitus (DM), and CVD (8,9,10,11,12,13). Perivascular fat is considered to be highly metabolically active, secreting substances with known vascular actions (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Perivascular fat is considered to be highly metabolically active, secreting substances with known vascular actions (8,9). TAT is a subtype of perivascular fat that can be quantified using multidetector computed tomography (MDCT) (11).…”

Section: Introductionmentioning

confidence: 99%

Thoracic periaortic adipose tissue is increased in patients with subclinical hypothyroidism

Akyürek

Efe

Kaya

2015

European Journal of Endocrinology

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Objective: To evaluate thoracic periaortic adipose tissue (TAT) volume in patients with subclinical hypothyroidism (SH) in comparison with controls and in relation to cardiovascular risk factors. Methods: The study population consisted of 28 newly diagnosed SH patients (mean (S.D.) age: 37.3 (G11.4) years, 85.7% were females) and 37 healthy volunteers (mean (S.D.) age: 35.3 (G10.7) years, 81.5% were females). Comparisons between patient and control groups used demographic characteristics, anthropometrics, and laboratory findings. All participants underwent thoracic radiographic assessment in the supine position, using an eight-slice multidetector computed tomography scanner and TAT volume was measured. Results: The TAT volume was determined to be 27.2 (G12.7) cm 3 in the SH group and 16.3 (G8.1) cm 3 in the control group, and the difference was statistically significant (P!0.001). In addition, TSH levels were significantly higher in the patient group compared with the control group (P!0.001). A significant correlation was also found between TSH levels and TAT volume (rZ0.572; P!0.001). In SH patients, no significant difference was noted in TAT levels with respect to sex (PZ0.383) or concomitant smoking status (PZ0.426). Conclusions: Our findings indicate that SH patients have significantly higher TAT values than controls and that increased TAT levels correlate with increased TSH levels.

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Pericardial and thoracic peri-aortic adipose tissues contribute to systemic inflammation and calcified coronary atherosclerosis independent of body fat composition, anthropometric measures and traditional cardiovascular risks

Cited by 66 publications

References 27 publications

Epicardial Adipose Tissue Volume and Left Ventricular Myocardial Function Using 3-Dimensional Speckle Tracking Echocardiography

Epicardial Adipose Tissue Volume and Left Ventricular Myocardial Function Using 3-Dimensional Speckle Tracking Echocardiography

Epicardial Fat Thickness and its Association with Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus

Thoracic periaortic adipose tissue is increased in patients with subclinical hypothyroidism

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