Pericardial angiosarcoma after mediastinal irradiation for seminoma: A case report and a review of the literature

Killion, Matthew J.; Brodovsky, Harvey; Schwarting, Roland

doi:10.1002/(sici)1097-0142(19960815)78:4<912::aid-cncr31>3.0.co;2-w

Cited by 26 publications

(14 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, no available studies provide data on the relationship between the prescribed radiation dose and RIS. RIS typically occurs within or at the edge of the radiation field [20]. Radiation doses greater than 50 Gy cause complete devitalization and bone death [21], while lower doses greater than 30 Gy are associated with permanent damage to the reparative mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced malignant fibrous histiocytoma of the maxilla

et al. 2011

View full text Add to dashboard Cite

Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual histiocytic and fibroblastic differentiation. We report on an MFH of the left maxilla that developed in a 79-year old woman 20 years after surgery and radiation for squamous cell carcinoma (SCC). Postoperative radiotherapy with 70 Gy was administered for a primary neoplasm of SCC of the left maxilla to a localized field through two lateral ports. This secondary neoplasm arose at the site of tumor resection (partial maxillectomy) within the irradiated field, and was resected. The development of sarcomas is a recognized complication of radiation therapy. The final diagnosis after the operation was MFH. The patient died of tumor recurrence at the skull base and within the cranium, 19 months after the operation. Radiation-induced sarcoma is well known, but radiation-induced MFH is relatively rare in the head and neck region. The details of this case are presented with a review of literature.

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation-induced malignant fibrous histiocytoma of the maxilla

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Pericardial angiosarcoma after RT is rare but has been described. 1 To our knowledge, this is the 2nd report of angiosarcoma of the pericardium after RT.…”

mentioning

confidence: 80%

“…Primary tumors of the pericardium are extremely rare, with an incidence of between 0.001% and 0.28% in an autopsy study 1 ; approximately 8% of those are angiosarcoma. In a study by Kirova and colleagues 2 of 16,705 patients who received radiation therapy (RT) for breast cancer, only 13 patients developed angiosarcoma of the breast, chest wall, or skin after a median follow-up period of 9.3 years.…”

mentioning

confidence: 99%

Angiosarcoma Causing Cardiac Constriction Late after Radiation Therapy for Breast Carcinoma

Sharma¹,

DeValeria²,

Scherber³

et al. 2016

Texas Heart Institute Journal

View full text Add to dashboard Cite

P ericardial constriction remains a difficult diagnosis that requires a high degree of clinical suspicion, careful clinical examination, and multimodality imaging. The cause of the constriction can be challenging to ascertain and often becomes evident only at the time of surgical resection. Such is the case we present.Primary tumors of the pericardium are extremely rare, with an incidence of between 0.001% and 0.28% in an autopsy study 1 ; approximately 8% of those are angiosarcoma. In a study by Kirova and colleagues 2 of 16,705 patients who received radiation therapy (RT) for breast cancer, only 13 patients developed angiosarcoma of the breast, chest wall, or skin after a median follow-up period of 9.3 years. Pericardial angiosarcoma after RT is rare but has been described.1 To our knowledge, this is the 2nd report of angiosarcoma of the pericardium after RT. Case ReportA 41-year-old woman presented with 8 weeks of progressive dyspnea, orthopnea, and cough. Her history included intracystic papillary carcinoma of the left breast 8 years earlier (treated with lumpectomy and postoperative RT). The details of the protocol and dosage of radiation used during the treatment were not available. The physical examination was consistent with pleural and pericardial effusions. The white cell count was elevated, as were the serum creatinine level (2 mg/dL [normal range, 0.6-1.1 mg/ dL] and the blood urea nitrogen level (46 mg/dL [normal range, 6-21 mg/dL]). Her other laboratory tests-coagulation profile, autoimmune/rheumatologic disease assay, and urinalysis-were within normal limits. A chest radiograph revealed bilateral pleural effusions. Computed tomography (Fig. 1) revealed a large amount of pericardial fluid extending to the aortic root, with an increased density suggesting hemorrhage or high protein content and a possible anterior mass over the right atrium, thought to represent an ill-defined mass or organized hematoma and pleural effusions.Transthoracic echocardiography revealed preserved left ventricular ejection fraction, diastolic dysfunction, bilateral pleural effusions, and evidence of effusive-constrictive pericarditis. Thoracocentesis and pericardiocentesis through a pericardial window revealed no malignant cells. Laboratory evaluation of the effusions for autoimmune and rheumatologic disease was negative.The patient underwent open-chest pericardiectomy for constrictive pericarditis. On the visceral pericardium, there were nodular masses-7-mm thick, rubbery, and dark red-brown-adherent to the parietal pericardium.Microscopically, these were spindle-cell neoplastic cells with marked nuclear pleomorphism, consistent with angiosarcoma (Fig. 2). The malignant cells expressed vimentin, factor VIII, podoplanin, and CD31, with focal expression of CD34. The

show abstract

“…Since primary and metastatic tumors are pathologically identical and because of the possibility of multicentric tumor, AS is diagnosed as primitive when a distant primary tumor is ruled out 4 . Only seventeen cases of primary angiosarcoma have been described in the literature [16][17][18][19][20][21][22][23][24] . Patients may present with hemorrhagic pericardial effusion, hemorrhagic pleuropericarditis, cardiac tamponade and thromboembolic phenomena.…”

Section: Discussionmentioning

confidence: 99%

“…Patients may present with hemorrhagic pericardial effusion, hemorrhagic pleuropericarditis, cardiac tamponade and thromboembolic phenomena. In one case report, pericardial AS occurs after mediastinal irradiation for seminoma 22 . There is a predominant right-sided location 21 .…”

Section: Discussionmentioning

confidence: 99%

Pancoast tobias syndrome revealing primary epithelioid pleuro-pericardial angiosarcoma: A case report and review of the literature

Coulibaly¹,

Marie-José²,

Pascal

et al. 2009

Indian J Thorac Cardiovasc Surg

View full text Add to dashboard Cite

Epithelioid angiosarcoma is a rare malignant vascular tumor with poor prognosis. Pleural or pericardial angiosarcomas are usually secondary tumors. We report a unique case of primary epithelioid angiosarcoma of the pleura and the pericardium in a 28-year-old man who was admitted for Pancoast Tobias syndrome. Thoracoscopy revealed a multifocal neoplasm and pleural biopsy showed a malignant tumor which histological and immunophenotypical features were characteristic of epithelioid angiosarcoma. (Ind J Thorac Cardiovasc Surg 2009; 25: 34-37)

show abstract

Pericardial angiosarcoma after mediastinal irradiation for seminoma: A case report and a review of the literature

Abstract: BACKGROUND.Second malignancies are a well recognized complication of radia-

Cited by 26 publications

References 25 publications

Radiation-induced malignant fibrous histiocytoma of the maxilla

Radiation-induced malignant fibrous histiocytoma of the maxilla

Angiosarcoma Causing Cardiac Constriction Late after Radiation Therapy for Breast Carcinoma

Pancoast tobias syndrome revealing primary epithelioid pleuro-pericardial angiosarcoma: A case report and review of the literature

Contact Info

Product

Resources

About