Pericardial disease after breast cancer radiotherapy

Marinko, Tanja

doi:10.2478/raon-2018-0035

Cited by 29 publications

(19 citation statements)

References 34 publications

(53 reference statements)

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“…Breast cancer (BC) is emerging as the leading cause of cancer-related deaths and the second highest mortality in women worldwide [1][2][3] . In the last few decades, outstanding advances have been achieved for breast cancer treatments, however, the morbidity and mortality are still high 4,5 . Existing research shows that the initiation factors inducing BC are complicated, including hormone disorders, heredity, environment.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

et al. 2020

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Compelling evidence has demonstrated the potential functions of circular RNAs (circRNAs) in breast cancer (BC) tumorigenesis. Nevertheless, the underlying mechanism by which circRNAs regulate BC progression is still unclear. The purpose of present research was to investigate the novel circRNA circRNF20 (hsa_circ_0087784) and its role in BC. CircRNA microarray sequencing revealed that circRNF20 was one of the upregulated transcripts in BC samples. Increased circRNF20 level predicted the poor clinical outcome in BC specimens. Functionally, circRNF20 promoted the proliferation and Warburg effect (aerobic glycolysis) of BC cells. Mechanistically, circRNF20 harbor miR-487a, acting as miRNA sponge, and then miR-487a targeted the 3'-UTR of hypoxia-inducible factor-1α (HIF-1α). Moreover, HIF-1α could bind with the promoter of hexokinase II (HK2) and promoted its transcription. In conclusion, this finding illustrates the vital roles of circRNF20 via the circRNF20/ miR-487a/HIF-1α/HK2 axis in breast cancer progress and Warburg effect, providing an interesting insight for the BC tumorigenesis.

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Section: Introductionmentioning

confidence: 99%

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

et al. 2020

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“…One of the RIHD after radiation is pericardial disease. This one is one of the earliest cardiac disorder after thoracic radiation and currently, near 5% to 6% of left breasts cancer cases treated with radiotherapy could develop it [30]. Pericardial disease after radiotherapy is dose-dependent and the mean cardiac absorbed dose described is near 36 or 40 Gy.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Radiotherapy-Induced Cardiac Complications: A Case Report

et al. 2019

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Patient: Male, 48Final Diagnosis: Late cardiac complications postradiotherapySymptoms: Chest pain • dyspnea • syncopeMedication: —Clinical Procedure: Diagnostic and therapeutic techniques in cardiologySpecialty: CardiologyObjective:Unusual or unexpected effect of treatmentBackground:Tumor disease has improved survival due to therapeutic advances and early diagnosis. However, anti-neoplastic treatment involves generating harmful side effects in the body, both in the short-term and in the long-term. One of the most important side effects is cardiovascular disease after radiotherapy, which in addition to being influenced by classic cardiovascular risk factors, can be also be influenced by anti-neoplastic therapy, and represents the main cause of death after a second cancer. We present a case that synthesizes the most relevant and determining aspects of radiotherapy-induced heart disease.Case Report:We present the case of a 48-year-old male with a personal history of mediastinal Hodgkin lymphoma who was treated with local radiotherapy 20 years ago, and who was admitted to hospital due to dyspnea and oppressive chest pain with efforts. He was diagnosed with severe aortic stenosis, and a coronary angiography confirmed the existence of coronary disease. Two years before, he had been admitted to hospital due to syncope and a pacemaker had been implanted. This patient experienced several cardiovascular complications that could be attributed to the radiotherapy treatment received in his past.Conclusions:Radiotherapy shows multiple cardiological complications, especially when applied at the thoracic level. This fact is very relevant, and this report can help determine the aspects of radiotherapy-induced heart disease affecting the mortality and morbidity of these patients.

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“…Radiation can also induce toxicity in organs such as heart, kidney and liver. Patients receiving radiation at the thoracic zone often show cardiotoxicity including pericardial disease and cardiovascular disease [ 94 , 95 ]. Urinary symptoms such as dysuria, hematuria, incontinence and frequency are also common sequela [ 96 ].…”

Section: Sequela Of Radiotherapy and Plant Extractsmentioning

confidence: 99%

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

et al. 2020

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Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation.

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Pericardial disease after breast cancer radiotherapy

Cited by 29 publications

References 34 publications

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

Long-Term Radiotherapy-Induced Cardiac Complications: A Case Report

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

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