Pericardial effusion with vesiculobullous lesions in a young female

Bullous lesions as a manifestation of systemic lupus erythematosus in two Mexican teenagers

“…The association of bullous SLE with lupus nephritis has been reported in adults [15-17]. It appears that the close relationship between bullous SLE and lupus nephritis is also important in children, as demonstrated by Sirka et al [11], Vijayalakshmi and Jayavardhana [12], Kumar and Agarwal [13], and the first of the two cases presented here.…”

“…It appears in less than 5% of patients with SLE, either in isolation or in addition to other cutaneous manifestations [15]. This condition usually affects young females, with only eleven cases reported in children [3-13] until now.…”

Unusual presentation of childhood Systemic Lupus Erythematosus

“…Bullous systemic lupus erythematosus (BSLE) is a rare, chronic, non-scarring blistering eruption, characterized by subepidermal blisters with acute predominantly neutrophilic inflammation in the upper dermis, immune complex linear deposition at the basement membrane by immunofluorescence, and immune deposits beneath the lamina densa by ultrastructural analysis [ 2 ]. Less than 5% patients with SLE develop vesiculobullous lesions in isolation or in addition to other cutaneous manifestations [ 3 ].…”

“…The precise delineation of bullous SLE from several primary blistering disorders (eg, bullous pemphigoid, dermatitis herpetiformis, pemphigus vulgaris, epidermolysis bullosa acquisita) is based on [ 1 ] widespread cutaneous vesiculobullous eruption [ 2 ] histology of skin lesions demonstrating acute neutrophilic upper dermal infiltrate and subepidermal separation [ 3 ] a positive direct or indirect immunofluorescence test demonstrating antibodies directed against the basement membrane [ 4 ] a tendency to respond to treatment with dapsone and [ 5 ] the presence of autoantibodies to type VII collagen as seen in epidermolysis bullosa acquisita (EBA).…”

Bullous Lupus: An Unusual Initial Presentation of Systemic Lupus Erythematosus in an Adolescent Girl

“…Bullous systemic lupus erythematosus (BSLE) is an autoantibody‐mediated subepidermal blistering disease that occurs in less than 5% of patients with systemic lupus erythematosus (SLE) (1). It occurs even less frequently in the pediatric population and only rarely presents as the initial manifestation of SLE (2).…”