Pericardial fluid cytology: An analysis of 128 specimens over a 6‐year period

Dragoescu, Ema; Liu, Lina

doi:10.1002/cncy.21246

Cited by 64 publications

(92 citation statements)

References 23 publications

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“…The incidence and cytomorphology of malignancies in body fluids have been described in adult patients, including results of ICC and other ancillary studies [1,2,3]. However, these parameters have not been adequately evaluated in pediatric patients and only a few studies in the earlier literature described the type of malignancies encountered in children [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Cytologic and Immunophenotypic Features of Malignant Cells in Pediatric Body Fluids

et al. 2015

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Objective: Cytospin preparations and immunocytochemistry are common methods in hospitals to evaluate malignancies in body fluids. Characteristics of malignant cells in pediatric body fluids have not been adequately evaluated. Study Design: 183 pleural, peritoneal and pericardial pediatric fluid specimens were examined by cytospin preparations and immunocytochemistry from two hospitals using similar procedural techniques. Cytologic diagnoses were correlated with the results of clinical history, histology and ancillary studies. Results: Forty cases with malignancy were identified (21.9%); the most common diagnoses were rhabdomyosarcoma and acute lymphoblastic lymphoma (9 and 8 cases, respectively). Small round cell tumors revealed similar morphology as clusters of small round cells with central nuclei and scant cytoplasm with frequent small vacuoles. Twenty-one cases were evaluated by immunocytochemistry, 12 by flow cytometry and 5 by cytogenetic analysis. CD3, CD20, TdT, CD10, desmin and myogenin were the most common markers. Staining artifacts causing interpretation difficulties were noted in 5 cases that were resolved by molecular studies and deferral for surgical specimens. Conclusions: Small round cell tumors are the most common malignancies encountered in pediatric body fluids and share a nonspecific morphology. Although immunocytochemistry is helpful to arrive at the correct diagnosis, other ancillary studies may be necessary, particularly in hematologic malignancies and other difficult cases.

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Section: Introductionmentioning

confidence: 99%

Cytologic and Immunophenotypic Features of Malignant Cells in Pediatric Body Fluids

et al. 2015

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“…One recent study of 128 cases showed similar results (24.2% malignant). 3 The percentage of malignant cases (12.5%) is similar with pleural effusions. 14 The majority of cases are diagnosed based on morphology and clinical history without ancillary studies.…”

Section: Discussionmentioning

confidence: 65%

“…However, in our series, "atypical cell" diagnosis only represents 3.7% of the total cases, which is much lower than other pleural and peritoneal effusion cytology specimens (w10%) in our institution. Other studies have shown an even lower atypical diagnostic rate (1.6%), 3 suggesting that reactive mesothelial cells in pericardial effusions do not cause significant diagnostic difficulty compared with other serous cavities.…”

Section: Discussionmentioning

confidence: 95%

“…The most recent article analyzed 128 pericardial specimens over a 6-year period and identified 31 malignant pericardial effusions. 3 Another study collected cases spanning a period of 24 years and identified 375 cases, with 65 cases of malignant pericardial effusion. 4 The sparse literature on the subject can be explained by the relatively rare occurrence of malignant pericardial effusions, and an unwillingness on behalf of clinical teams to perform pericardiocentesis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical presentation and cytopathologic features of malignant pericardial cytology: a single institution analysis spanning a 29-year period

Zhu

Booth

Reynolds

2015

Journal of the American Society of Cytopathology

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“…Pericardiocentesis is the gold standard for elucidating specific etiology. The main clinical purpose of the cytopathological evaluation is to identify malignant tumor cells and this method has a sensitivity of 66%-100% (19,20) . In conclusion, detection of etiology in pericardial effusions is very challenging and time consuming.…”

Section: Discussionmentioning

confidence: 99%

Could the cytological evaluation of pericardial effusions illuminate our path?

Ekmekçi¹,

Ekmekçi²,

Dere³

et al. 2018

Terh

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Objective: Pericardial effusion (PE) is a common clinical condition that can develop as a result of systemic or heart disease. In our study, we synthesized the cytopathological and clinical results of patients who underwent pericardiocentesis due to pericardial effusion. Method: A total of 213 patients who underwent percutaneous pericardiocentesis between 2007-2017 were included in the study: their cytologic and histopathologic diagnoses were noted and their relations were examined. Results: Hundred and thirty-two cases were male (61.9%), 81 were female (38.1%) and the mean of the study population age was 59.9 (min 13-max 97) years. Hundred and sixty-eight patients had benign (78.9%), 10 suspicious (4.6%), 3 non-diagnostic (1.4%) and 32 malignant cytologies (15.1%). Benign pericardial effusion was the most common diagnosis. Malignant cytology findings were interpreted as lung carcinoma (n=20: 62.5%), rhabdomyosarcoma (n=1: 3.1%), poorly differentiated adenocarcinoma (n=2: 6.2%), a gastrointestinal system carcinoma (n=4: 12.5%), undifferentiated epithelial tumor (n=1: 3.1%), breast carcinoma (n=1: 3.1%), and unspecified malignant tumor (n=3: 9%). Four (2.4%) of the 168 patients having diagnosis of benign cytology had previously received diagnosis of a malignant disease, however examination of cytological specimen. Did not reveal any malignancy. Three (30%) of the 10 patients with suspicious cytology, had received diagnosis of a malignant disease previously. Conclusion:In developed countries, it is reported that more than 50% of the PE's are idiopathic. The percentage of cancer-associated PE's is 10-25%. In our study, 78.9% of our cases had a benign diagnosis, and 15.1% had malignant PE consistent with the literature findings. Cytological sampling in pericardial fluid is a method that can shed light on the diagnosis of many diseases.

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Pericardial fluid cytology: An analysis of 128 specimens over a 6‐year period

Cited by 64 publications

References 23 publications

Cytologic and Immunophenotypic Features of Malignant Cells in Pediatric Body Fluids

Cytologic and Immunophenotypic Features of Malignant Cells in Pediatric Body Fluids

Clinical presentation and cytopathologic features of malignant pericardial cytology: a single institution analysis spanning a 29-year period

Could the cytological evaluation of pericardial effusions illuminate our path?

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