Pericardial mesothelioma presenting as a suspected ST-elevation myocardial infarction

Barroso, Ana Sofia; Leite, Sérgio; Friões, Fernando; Vasconcelos, M. Teresa S. D.; Azevedo, Daniela; Baldaia, Helena; Amorim, Mário Jorge; Dias, Paula

doi:10.1016/j.repce.2016.03.014

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…The use of speckle tracking imaging to assess cardiac strain has been confirmed to be sensitive of detecting subclinical myocardial impairment by a large body of evidence, and might be helpful to detect early subtle myocardial lesions in PPM [ 17 ]. Severe case with myocardial necrosis was reported in one 77-year-old male, manifesting as severe dyspnea, ST segment elevation, increased cardiac troponin level and hypokinetic ventricular wall motion in the patient cohort, similar to a 75-year-old woman with suspected ST-elevation myocardial infarction reported by Barroso et al [ 18 ].…”

Section: Discussionsupporting

confidence: 76%

Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study

Kong

Li²,

Wang

et al. 2018

Cardiovasc Ultrasound

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BackgroundLittle is known about the echocardiographic characteristics of primary malignant pericardial mesothelioma (PPM) due to its rarity. The aim of this study was to explore the sex-specific echocardiographic patterns of PPM and risk factors for in-hospital mortality.MethodsA retrospective information retrieval was conducted for cases of PPM reported from China during 1981 and 2015. The diagnosis was made by histopathological examinations and only cases with echocardiographic descriptions were included. Data on the clinical and echocardiographic findings were collected. Difference in clinical, sex-specific echocardiographic characteristics and findings across different time periods were assessed. Logistic regression analysis was performed to explore echocardiographic risk factors for in-hospital mortality.ResultsA total of 64 patients with PPM were included, with a mean age of 39.2 ± 15.6 years and minor male dominance (40, 62.5%). The most common echocardiographic presentations were pericardial effusion (55, 85.9%), pericardial masses (36.4%) and thickening (17.3%), respectively. The positive rate of pericardiocentesis was only 20.9%. Six patients (15.4%) died among 39 cases reporting in-hospital outcome. Logistics analysis identified no clinical or echocardiographic parameters associated with in-hospital mortality (all P > 0.05).ConclusionsThe echocardiographic signs of PPM are basically nonspecific with massive pericardial effusion as the most common sign, although no echocardiographic gender differences or association with in-hospital mortality could be identified.

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Section: Discussionsupporting

confidence: 76%

Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study

Kong

Li²,

Wang

et al. 2018

Cardiovasc Ultrasound

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Malignant primary pericardial mesothelioma presenting as effusive constrictive pericarditis: a case report study

Savarrakhsh

Vakilpour

Davani

et al. 2021

J Cardiothorac Surg

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Background Primary pericardial mesothelioma (PPM) is a rare malignancy with a high prevalence of mortality. The diagnosis is usually challenging using a variety of imaging modalities and invasive procedures and is generally performed at the later stages of the disease or in autopsy. This case study points to an unconventional presentation of PPM and the challenges in diagnosing this rare mortal malignancy. Case presentation This study presents a 44-year-old woman with no remarkable medical history with an initial diagnosis of effusive constrictive pericarditis at first hospitalization. Imaging evaluations, including transthoracic echocardiography and chest computed tomography scan, demonstrated visible thickened pericardium, pericardial effusion, and mass-like lesions in pericardium and mediastinum. The definite diagnosis of primary pericardial mesothelioma was established after pericardiectomy and histopathology examinations. Chemotherapy with pemetrexed and carboplatin was administrated to the patient, and she has been through four cycles of chemotherapy with no complications to date. Conclusion Constrictive pericarditis is an uncommon presentation of PPM. Due to the high mortality rate and late presentation, difficulties and uncertainties in diagnosis, being aware of this rare malignant entity in different cardiac manifestations, particularly when there is no clear explanation or response to treatment in such conditions, is highly important.

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Pericardial mesothelioma presenting as a suspected ST-elevation myocardial infarction

Cited by 2 publications

References 12 publications

Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study

Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study

Malignant primary pericardial mesothelioma presenting as effusive constrictive pericarditis: a case report study

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