Pericardiocentesis and systemic cytotoxic chemotherapy in the management of cardiac tamponade secondary to disseminated breast carcinoma.

Ramakrishnan, S.; Marshall, A.; Pickard, Julie; Tyrrell, C.J.

doi:10.1136/hrt.60.2.162

Cited by 8 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the echocardiographic finding of a mass in the left atrium accompanied by fever was not enough to lead clinicians to favor a working diagnosis of myxoma. While breast cancer has been reported to cause malignant pericardial effusion, 7 true intracavitary metastases (as suspected in this case) are rare. Tumor encasement of the heart in a case of breast cancer has been reported.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Cytologic Diagnosis of Unsuspected Cardiac Myxoma

Meir¹,

Maly²,

Doviner³

et al. 2004

Acta Cytologica

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Intraoperative Cytologic Diagnosis of Unsuspected Cardiac Myxoma

Meir¹,

Maly²,

Doviner³

et al. 2004

Acta Cytologica

View full text Add to dashboard Cite

“…The pericardial fluid was malignant in 97.4% (n=42) of the cases and benign in one patient. From the studies that reported the time to tamponade [2,3,7,8,[10][11][12][13][14][15][16]18], the median time to the occurrences of cardiac tamponade after the first cancer treatment was 26 months (0-156). There was no evidence of metastases to other extra-pericardial secondary sites in three of the included studies [11,13,15].…”

Section: Pathologic Characteristics Of Study Participantsmentioning

confidence: 99%

“…Fifteen studies reported survival time [1][2][3][4]7,[9][10][11][12][13][14][15][16][17][18]. The median survival time after diagnosis of tamponade was 13 months (0.13-57) (Table 4).…”

Section: Table 4: Intervention and Outcomes Of Study Participantsmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac Tamponade in Patients With Breast Cancer: A Systematic Review

Ilerhunmwuwa¹,

Sedeta²,

Wasifuddin³

et al. 2022

Cureus

View full text Add to dashboard Cite

Cardiac tamponade is a rare presentation in breast cancer and may be associated with poor prognosis. In this article, we reviewed the characteristics and survival outcomes of patients with breast cancer who developed cardiac tamponade. Three databases (PubMed, EMBASE and SCOPUS) were searched for relevant articles published from 1978 to 2022 and 16 articles were identified comprising 64 cases. The median age of the cases was 52 years. Cardiac tamponade was diagnosed with echocardiogram or computerized tomography of the chest or both in 91.9%, 1.6% and 6.5% of the cases, respectively. Cytology of the pericardial fluid was done in 90.5% of the cases while biopsy in addition to cytology was done in 9.5% of cases. Tamponade was proven to be malignant in 97.4% of the cases. The initial treatment for tamponade was pericardiocentesis. Adjunct therapies ranged from the insertion of a pericardial window, pericardiectomy, radiotherapy and chemotherapy. The median time from the first treatment of breast cancer to the onset of tamponade was 24 months while the median survival following diagnosis of tamponade was 13 months. There was no significant correlation (spearman rank-sum correlation coefficient = 0.35, p = 0.165) between time to tamponade (interval time from the first diagnosis of breast cancer and the onset of cardiac tamponade) and survival. Cardiac tamponade may adversely affect survival in patients with breast cancer. Early diagnosis with echocardiogram and cytology may guide management and expectations. Further observational studies are needed to determine the predictors of cardiac tamponade and optimal treatment in patients with breast cancer.

show abstract

“…Without any additional treatment, the rate of recurrence is high (up to 40%) and by extending the drainage for several days, the rate of recurrence is reduced [66] . Systemic CT without further local interventions has been reported to be effective in lymphomas and in some cases of solid tumors (mostly breast and ovarian) [67][68][69][70][71][72] .…”

Section: Percutaneous Drainagementioning

confidence: 99%

Neoplastic pericardial disease: Old and current strategies for diagnosis and management

Lestuzzi¹

2010

WJC

View full text Add to dashboard Cite

The prevalence of neoplastic pericardial diseases has changed over time and varies according to diagnostic methods. The diagnostic factor is usually the detection of neoplastic cells within the pericardial fluid or in specimens of pericardium, but the diagnosis may be difficult. Accurate sampling and cytopreparatory techniques, together with ancillary studies, including immunohistochemical tests and neoplastic marker dosage, are essential to obtain a reliable diagnosis. The goals of treatment may be simply to relieve symptoms (cardiac tamponade or dyspnea), to prevent recurrent effusion for a long-term symptomatic benefit, or to treat the local neoplastic disease with the aim of prolonging survival. Immediate relief of symptoms may be obtained with percutaneous drainage or with a surgical approach. For long term prevention of recurrences, various approaches have been proposed: extended drainage, pericardial window (surgical or percutaneous balloon pericardiostomy), sclerosing local therapy, local and/or systemic chemotherapy or radiation therapy (RT) (external or with intrapericardial radionuclides). The outcomes of various therapeutic approaches vary for different tumor types. Lymphoma and leukemias can be successfully treated with systemic chemotherapy; for solid tumors, percutaneous drainage and the use of systemic and/or local sclerosing and antineoplastic therapy seems to offer the best chance of success. The use of "pure" sclerosing agents has been replaced by agents with both sclerosing and antineoplastic activity (bleomycin or thiotepa), which seems to be quite effective in breast cancer, at least when associated with systemic chemotherapy. Local chemotherapy with platinum, mitoxantrone and other agents may lead to good local control of the disease, but the addition of systemic chemotherapy is probably relevant in order to prolong survival. The surgical approach (creation of a pericardial window, even with the mini-invasive method of balloon pericardiostomy) and RT may be useful in recurring effusions or in cases that are refractory to other therapeutic approaches.

show abstract

Pericardiocentesis and systemic cytotoxic chemotherapy in the management of cardiac tamponade secondary to disseminated breast carcinoma.

Abstract: SUMMARY Three patients with cardiac tamponade secondary to disseminated breast carcinoma were treated by pericardiocentesis followed by systemic cytotoxic chemotherapy. This approach controlled pericardial effusion in all the patients and extended their survival.

Cited by 8 publications

References 12 publications

Intraoperative Cytologic Diagnosis of Unsuspected Cardiac Myxoma

Intraoperative Cytologic Diagnosis of Unsuspected Cardiac Myxoma

Cardiac Tamponade in Patients With Breast Cancer: A Systematic Review

Neoplastic pericardial disease: Old and current strategies for diagnosis and management

Contact Info

Product

Resources

About