Pericarditis Epistenocardica or Dressler Syndrome? An Autopsy Case

Feola, Alessandro; Stefano, Noè De; Pietra, Bruno Della

doi:10.1155/2015/215340

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Pericarditis is a common sequelae of transmural myocardial infarction (MI) and arises “early” as pericarditis epistenocardica or as a “delayed” presentation in the form of Dressler syndrome[ 25 ].…”

Section: Clinical Models Of Post Inflammatory Pericarditismentioning

confidence: 99%

“…DS is presumably a recurrent immune-inflammatory syndrome arising from the release of auto-myocardial antigens from necrosis of myocardial tissues. The formation of immune complexes are believed to trigger a hypersensitivity reaction from molecular mimicry and cross-reactions[ 25 , 30 ]. Indeed, the presence of increased anti-myocardial antibodies following myocardial injury has been previously suggested and supports a possible autoimmune pathogenesis[ 31 ].…”

Section: Clinical Models Of Post Inflammatory Pericarditismentioning

confidence: 99%

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Established and novel pathophysiological mechanisms of pericardial injury and constrictive pericarditis

Ramasamy¹,

Mayosi²,

Sturrock³

et al. 2018

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This review article aims to: (1) discern from the literature the immune and inflammatory processes occurring in the pericardium following injury; and (2) to delve into the molecular mechanisms which may play a role in the progression to constrictive pericarditis. Pericarditis arises as a result of a wide spectrum of pathologies of both infectious and non-infectious aetiology, which lead to various degrees of fibrogenesis. Current understanding of the sequence of molecular events leading to pathological manifestations of constrictive pericarditis is poor. The identification of key mechanisms and pathways common to most fibrotic events in the pericardium can aid in the design and development of novel interventions for the prevention and management of constriction. We have identified through this review various cellular events and signalling cascades which are likely to contribute to the pathological fibrotic phenotype. An initial classical pattern of inflammation arises as a result of insult to the pericardium and can exacerbate into an exaggerated or prolonged inflammatory state. Whilst the implication of major drivers of inflammation and fibrosis such as tumour necrosis factor and transforming growth factor β were foreseeable, the identification of pericardial deregulation of other mediators (basic fibroblast growth factor, galectin-3 and the tetrapeptide Ac-SDKP) provides important avenues for further research.

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Section: Clinical Models Of Post Inflammatory Pericarditismentioning

confidence: 99%