Pericarditis in Systemic Rheumatologic Diseases

Kontzias, Apostolos; Barkhodari, Amir; Yao, Qingping

doi:10.1007/s11886-020-01415-w

Cited by 27 publications

(32 citation statements)

References 98 publications

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“…For example, about a 20% increased chance of developing AS was observed in those who inherit HLA-B27 and have a parent with AS. 28 However, in this case, and in our study, having a family history resulted in an earlier diagnosis of AS. The same as in the study Dincer et al showed that patients with a family history of AS had a shorter diagnostic delay.…”

Section: Discussioncontrasting

confidence: 42%

The Time Lag Between the Onset of Symptoms and Diagnosis of Ankylosing Spondylitis in Sulaymaniyah Province, Iraq

Merza

Mustafa

2022

Hosp Pract Res

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Background: Ankylosing spondylitis (AS) is a chronic, progressive, and disabling disease among rheumatological diseases. Objectives: Current study aimed to investigate the Time lag between the onset of symptoms and final diagnosis of AS, and also identify the factors that contribute to that delay in Sulaymaniyah province. Methods: In this cross-sectional study, 104 (AS) patients who satisfied the modified New York 1984 criteria were enlisted. The time lag was defined as the diagnosis delay (DD) between the appearance of the first symptoms and the correct diagnosis of AS. Spearman correlation analysis was used to detect correlations between variables. Results: The higher percentage of variables with DD≥6 years were urban 32 (74.4%), housewife 15(34.9%), had no family history 42 (97.7%), with high diploma 33 (76.7%), and positive HLAB27 31 (72.1%), the first specialist consulted orthopedics 21(48.8%) then GP 6 (14.9). Moreover, the higher percentage of variables with DD<6 years were diagnosis years between 2000 to 2020, rural 55 (90.2), 39 (63.9%) respectively, higher education 47 (77%), employee and worker 22 (36.1%), positive family history 44 (72.1%), positive human leukocyte antigen (HLAB27-61) (100%), inflammatory back pain 47 (77%), rheumatologist 29 (47.5%). The average year’s DD is 6.48. A statistically significant positive correlation was detected between the DD and age, age at diagnosis but, a negative correlation was found between the DD time and, age at symptom onset. Conclusion: The Time lag between the onset of symptoms of AS and the final diagnosis in Sulaymaniyah was 6.48 years. (HLA-B27), age, age at diagnosis, education level, occupation, 1st specialist, 1st symptom at onset of disease and family history are the factors that affect delayed diagnosis in Sulaymaniyah patients with AS.

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Section: Discussioncontrasting

confidence: 42%

The Time Lag Between the Onset of Symptoms and Diagnosis of Ankylosing Spondylitis in Sulaymaniyah Province, Iraq

Merza

Mustafa

2022

Hosp Pract Res

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“…In general, complications of rheumatoid arthritis-associated pericarditis are related to the disease activity of rheumatoid arthritis [7]. When a patient with poorly controlled rheumatoid arthritis complains of symptoms, such as chest pain, dyspnea, and lower leg edema, it is necessary to proceed with a systematic and detailed evaluation to rule out pericarditis [10]. In this case, it may have been difficult to suspect the complication of pericarditis because the joint symptoms were not critical.…”

Section: Discussionmentioning

confidence: 99%

Pericarditis With Cardiac Tamponade Mimicking Yellow Nail Syndrome in a Patient With Rheumatoid Arthritis and a Paucity of Joint Symptoms

Tokonami¹,

Ohta²,

Tanaka³

et al. 2022

Cureus

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Pericarditis is a cardiac disease that commonly manifests with rheumatoid arthritis, and its complications are related to rheumatoid arthritis disease activity. The diagnosis can be complicated in patients with multiple extra-joint complications of rheumatoid arthritis. We report a case of pericarditis in an 82-year-old woman with few joint symptoms who was admitted to the hospital due to worsening edema of the lower legs and dyspnea, which progressed to cardiac tamponade. The patient presented with gradual onset of edema of both lower limbs and bilateral pleural effusion and was initially diagnosed with yellow nail syndrome. Ultimately, the patient was diagnosed with rheumatoid pericarditis due to a rapid increase in pericardial effusion. She was treated with non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine; however, the symptoms were progressive and required pericardiocentesis. After pericardiocentesis, the patient responded well to NSAIDs and colchicine, and systemic edema was relieved. This case highlights the fact that pericarditis associated with rheumatoid arthritis is not necessarily related to the severity of joint symptoms. Moreover, it can be difficult to differentiate pericarditis from multiple other diseases, such as yellow nail syndrome, in patients with rheumatoid arthritis who mainly have extra-articular symptoms.

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“…Рассматривая потенциальные «кардиологические» показания для назначения анакинры, следует принимать во внимание благоприятное влияние ингибиторов ИЛ-1 на прогрессирование атеросклероза и снижение риска осложнений после перенесенного острого инфаркта миокарда [214][215][216][217][218][219]. Другим потенциальным показанием для назначения анакинры при РА (и других ИВЗ) является развитие резистентного перикардита и плеврита [291]. Следует иметь в виду целесообразность применения анакинры у тяжелых пациентов с подагрическим артритом и другими микрокристаллическими артритами, частыми коморбидными патологиями при которых являются ЗСН, СД2 и хроническая болезнь почек [102, [292][293][294], затрудняющие применение стандартной терапии (НПВП, глюкокортикостероиды).…”

Section: Discussionunclassified

“…Научно-практическая ревматология. 2022;60(3):[280][281][282][283][284][285][286][287][288][289][290][291][292][293][294][295][296][297][298] …”

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The role of interleukin 1 in the development of human diseases: focus on Anakinra (IL-1 receptor antagonist)

Насонов

Samsonov

2022

Naučno-praktičeskaâ revmatologiâ

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According to modern concepts, human immune-mediated inflammatory diseases (IMIDs), depending on the prevailing mechanisms of immunopathogenesis, are divided into two main categories – autoimmune and autoinflammatory.At the same time, both autoimmune and autoinflammatory mechanisms are involved in the pathogenesis of most IMIDs, the complex interaction of which is reflected in the polymorphism of clinical manifestations, course variants, outcomes, and therapy efficacy. It is assumed that hyperproduction of cytokines of the interleukin (IL) 1 family, which is one of the key regulators of innate immunity, determines the “crossover” between the mechanisms of autoinflammation and autoimmunity in IMIDs. Anakinra is currently used in clinical practice to suppress the pathological effects of IL-1. An analysis of the results of the clinical use of Anakinra indicates that treatment with this drug should be considered as a promising direction in the pharmacotherapy of systemic autoinflammatory diseases (SAIDs) and critical conditions in children and adults associated with the development of hyperinflammation. The main directions of the Anakinra clinical research program are presented, including: determining the place of the drug in the implementation of the "Treat to Target" strategy and personalization of therapy, primarily in patients with “resistant” (difficult-to-treat) subtype of rheumatoid arthritis and comorbid pathology, as well as with severe forms of microcrystalline arthritis; the possibility of using Anakinra to improve the early diagnosis of SAIDs in children and adults; creation of the Russian register of patients with SAIDs, who are potentially indicated for treatment with Anakinra.

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Pericarditis in Systemic Rheumatologic Diseases

Cited by 27 publications

References 98 publications

The Time Lag Between the Onset of Symptoms and Diagnosis of Ankylosing Spondylitis in Sulaymaniyah Province, Iraq

The Time Lag Between the Onset of Symptoms and Diagnosis of Ankylosing Spondylitis in Sulaymaniyah Province, Iraq

Pericarditis With Cardiac Tamponade Mimicking Yellow Nail Syndrome in a Patient With Rheumatoid Arthritis and a Paucity of Joint Symptoms

The role of interleukin 1 in the development of human diseases: focus on Anakinra (IL-1 receptor antagonist)

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