Pericranial nerve blockade as a preventive treatment for migraine: Experience in 60 patients

Piñero, M. Ruíz; Carrillo, P. Mulero; Hueso, M.I. Pedraza; Rodríguez, C. de la Cruz; Mesonero, L. López; Peral, Á.L. Guerrero

doi:10.1016/j.nrleng.2016.07.001

Cited by 13 publications

(30 citation statements)

References 26 publications

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“…Both the authors independently read the titles and the abstracts and excluded the articles which prima facie did not address our review question regarding the efficacy and safety of the GON block in CM. Thirteen open-label studies 29,[32][33][34][35][36][37][38][39][40][41][42][43] and 10 placebo-controlled trials [44][45][46][47][48][49][50][51][52][53] were read in detail. Of these, nine open-label studies 29,[34][35][36][38][39][40][41]43 and four placebo-controlled studies [47][48][49][50] were found suitable for the present review meeting the inclusion and exclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, nine open-label studies 29,[34][35][36][38][39][40][41]43 and four placebo-controlled studies [47][48][49][50] were found suitable for the present review meeting the inclusion and exclusion criteria. Four open-label 32,33,37,42 and six placebo-controlled studies [44][45][46][51][52][53] that were excluded for efficacy and safety analysis have been briefly described separately (Appendix 1) to highlight the reasons for their exclusion. because of biases, uncontrolled open-label studies often pave the way for the proper conduct of RCTs if some beneficial effects are observed and the hypothesis is generated.…”

Section: Resultsmentioning

confidence: 99%

“…Piñero et al included 60 migraine patients, 43 of whom had CM. 37 Besides using dual blocks (GON block and SON block), the study did not show the results separately for CM and hence excluded. A proof of concept study by Vanderpol and Jonker evaluated the influence of patient positioning on clinical outcomes after GON block for treatment of various headaches including CM.…”

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

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Role of greater occipital nerve block for preventive treatment of chronic migraine: A critical review

Chowdhury

Mundra

2020

Cephalalgia Reports

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Objective: The aim of this study is to critically analyze the evidence of the efficacy and safety of greater occipital nerve (GON) block for the preventive treatment of chronic migraine (CM). Background: A rigorous scientific assessment of efficacy and safety of the GON block for preventive treatment in CM is not available. This critical review was undertaken for this purpose. Methods: References for this review were identified by searches of articles published in the English language in PubMed between 1969 and April 15, 2020 using “greater occipital nerve block,” “chronic migraine,” “migraine,” “headache,” and “treatment” as keywords. Results: Out of potential 532 articles, 9 open-label and 4 placebo-controlled trials that studied the role of GON block for prevention of CM were identified and reviewed. Open-label trials reported a reduction of headache severity and frequency in 35–68% of patients. The beneficial effect of a single block lasted up to 4 weeks. Randomized controlled trials (RCTs) used varied methodology and techniques of GON block and the outcomes were reported at different time points. A single RCT showed a beneficial effect of the GON block at 1 week. However, the GON block was found to be safe and well tolerated. Conclusion: Long-term efficacy of GON block in CM shall need further well-designed RCTs using standardized methodology. This study, in addition, reviewed the limitations and uncertainties regarding the technique and methods of use of GON block in CM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Declaration Of Conflicting Interestsmentioning

confidence: 99%

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Role of greater occipital nerve block for preventive treatment of chronic migraine: A critical review

Chowdhury

Mundra

2020

Cephalalgia Reports

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“…In this review, 14 trials on GON block for migraine treatment are summarized; however, one of these trials consists of patients with migraine but also cluster headache, new daily persistent headache, and hemicrania continua (15–28). Seven of these trials were RCTs (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Lidocaine was used in one trial (16). In addition, a mixture of bupivacaine and mepivacaine (27) and a mixture of bupivacaine and lidocaine (15) was used in just one trial. (Table 1 and Table 2).…”

Section: Resultsmentioning

confidence: 99%

Greater occipital nerve block in migraine prophylaxis: Narrative review

İnan

Unal-Artık

et al. 2019

Cephalalgia

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Objectives The importance and popularity of peripheral nerve block procedures have increased in the treatment of migraine. Greater occipital nerve (GON) block is a commonly used peripheral nerve block method, and there are numerous researches on its use in migraine treatment. Materials and methods A search of PubMed for English-language randomized controlled trials (RCT) and open studies on greater occipital nerve block between 1995 and 2018 was performed using greater occipital nerve, headache, and migraine as keywords. Results In total, 242 potentially relevant PubMed studies were found. A sum of 228 of them which were non-English articles and reviews, case reports, letters and meta-analyses were excluded. The remaining articles were reviewed, and 14 clinical trials, seven of which were randomized-controlled on greater occipital nerve block in migraine patients, were identified and reviewed. Conclusions Although clinicians commonly use greater occipital nerve block in migraine patients, the procedure has yet to be standardized. The present study reviewed the techniques, drugs and dosages, the frequency of administration, side effects, and efficacy of greater occipital nerve block in migraine patients.

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Evaluation of the efficacy of peripheral nerve block alone in episodic and chronic migraine patients

Evcili

Yabalak

2023

Arq Neuropsiquiatr

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Background Peripheral nerve block (PNB) is usually performed in patients with migraine who are resistant to treatment with medications. Objective To compare the efficacy of PNB alone and PNB combined with prophylactic medications in migraine patients. Method The data on migraine patients who underwent PNB in our clinic between November 2019 and January 2022 were retrospectively reviewed. Blocks of the greater occipital nerve (GON), lesser occipital nerve (LON) and supraorbital nerve (SON) were performed upon admission and in the second week. Results The study included 116 patients. While 21 out of 39 episodic migraine (EM) patients continued to use prophylactic medications, 18 were followed up with PNB alone. While 49 out of 77 chronic migraine (CM) patients continued to use prophylactic medications, 28 were followed up with PNB alone. Comparison of the admission and second-month data of the patients who only underwent PNB and those who continued the drug treatment together with PNB in both the EM and the CM group showed that the number of days with pain, number of analgesics taken and scores on the Visual Analog Scale (VAS) and the Migraine Disability Assessment (MIDAS) were significantly reduced in both groups (p < 0.01). Comparison of the second-month data of the patients followed up with PNB alone and those followed up with PNB together with prophylactic medications showed that there was no significant difference between the EM and CM patients (p > 0.05). Conclusion Bilateral GON, LON and SON block with lidocaine injection seems to be an effective treatment on its own, without the need for prophylactic medications, in both EM and CM patients during a two-month follow-up.

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Pericranial nerve blockade as a preventive treatment for migraine: Experience in 60 patients

Cited by 13 publications

References 26 publications

Role of greater occipital nerve block for preventive treatment of chronic migraine: A critical review

Role of greater occipital nerve block for preventive treatment of chronic migraine: A critical review

Greater occipital nerve block in migraine prophylaxis: Narrative review

Evaluation of the efficacy of peripheral nerve block alone in episodic and chronic migraine patients

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