Pericytes as a Supplementary Source of Osteoblasts in Periosteal Osteogenesis

Díaz‐Flores, Lucio; Gutiérrez, Ricardo; López-Alonso, Antonio; González, Ricardo; Várela, H.

doi:10.1097/00003086-199202000-00042

Cited by 205 publications

(132 citation statements)

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“…Furthermore, a study by Lounev et al (2009) identified the presence of Tie2-cre labelled cells within ectopic osteochondrogenic tissue of HO [56]. Together, this data supports a role for endothelial progenitor cells in throughout the fibroproliferative, adipogenic and osteochondrogenic stages of HO (see Diagram 3) However, the role of endothelial cells/progenitors was recently called into question following the publication of data showing that the Tie2 positive cells found in endochondral bone lacked the expression of VE-Cadherin, a principal endothelial marker protein [93]. Furthermore, Tie2 + cells only accounted for approximately one half of the cells present within the ectopic bone mass [56].…”

Section: Endoderm Endothelial Cellsmentioning

confidence: 74%

Identifying the Cellular Mechanisms Leading to Heterotopic Ossification

et al. 2015

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Section: Endoderm Endothelial Cellsmentioning

confidence: 74%

Identifying the Cellular Mechanisms Leading to Heterotopic Ossification

et al. 2015

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“…Together with dense capillary network this layer contains abundance of endothelial pericytes. 32 Pericytes are polymorphic cells of mesenchymal origin, which contain multiple, branching cytoplasmic processes that partially surround capillaries. Pericytes are found in the microvasculature of connective tissue, nervous tissue, muscle tissue and the lungs.…”

Section: Microscopic Featuresmentioning

confidence: 99%

“…29 Pericytes are cells in physical contact with capillary endothelial cells, with the ability to differentiate into numerous cell types, including osteoblasts. 14,101,133 These cells may serve as a supplementary source of osteoprogenitor cells 32 and may be more important in periosteal bone formation due to their greater abundance in periosteum 20 than in endosteal bone surface apposition. 14 Cultured pericytes mineralize in vitro and synthesize the osteoblast marker, alkaline phosphatase, as well as bone matrix proteins, including osteocalcin, 20 osteonectin, osteopontin, and bone sialoprotein.…”

Section: Microscopic Featuresmentioning

confidence: 99%

RETRACTED: The periosteum

Augustin¹,

Antabak²,

Davila³

2007

Injury

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“…Pericytes have been isolated from the microvasculature of connective tissues; nervous tissue including the cerebral cortex, peripheral nerves, and the retina; muscle tissue; and the lungs [51][52][53][54][55][56][57].…”

Section: Osteogenic Progenitors Are Not Exclusive To Skeletal Tissuesmentioning

confidence: 99%

“…Diaz-Florez et al labeled pericytes and endothelial cells with monastral blue and, consequently, followed the fate of the pericyte in the process of new bone formation [53]. Six days after activation of the periosteum, the dye was found in newly formed osteoblasts.…”

Section: Osteogenic Progenitors Are Not Exclusive To Skeletal Tissuesmentioning

confidence: 99%

Cell Therapy for Bone Disease: A Review of Current Status

et al. 2003

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Bone marrow is a reservoir of pluripotent stem/progenitor cells for mesenchymal tissues. Upon in vitro expansion, in vivo bone-forming efficiency of bone marrow stromal cells (BMSCs) is dramatically lower in comparison with fresh bone marrow, and their in vitro multidifferentiation potentials are gradually lost. Nevertheless, when BMSCs are isolated and expanded in the presence of fibroblast growth factor 2, the percentage of cells able to differentiate into the osteogenic, chondrogenic, and adipogenic lineages is greater. Osteogenic progenitors are not exclusive to skeletal tissues. We could also think of cells in different adult tissues as potentially capable of following an osteochondrogenic differentiation pathway, but, under normal physiological conditions, they are inhibited in this process by the environment and/or the adjacent cell populations. When, for some reason such as pathology, the environment changes dramatically and the inhibiting condition is removed, these cells could become osteoblasts. Bone is repaired via local delivery of cells within a scaffold. Bone formation was first assessed in small animal models. Large animal models were successively developed to prove the feasibility of the tissue engineering approach in a model closer to a real clinical situation. Eventually, pilot clinical studies were performed. Extremely appealing is the possibility of using mesenchymal progenitors in the therapy of genetic bone diseases via systemic infusion. There is experimental evidence to suggest that mesenchymal progenitors delivered by this route engraft with a very low efficiency and do not produce relevant and durable clinical effects. Under some conditions, where the local microenvironment is either altered (i.e., injury) or under important remodeling processes (i.e., fetal growth), engraftment of stem and progenitor cells seems to be enhanced. A better understanding of their engraftment mechanisms will, hopefully, extend the field of therapeutic applications of mesenchymal progenitors.

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Pericytes as a Supplementary Source of Osteoblasts in Periosteal Osteogenesis

Cited by 205 publications

References 0 publications

Identifying the Cellular Mechanisms Leading to Heterotopic Ossification

Identifying the Cellular Mechanisms Leading to Heterotopic Ossification

RETRACTED: The periosteum

Cell Therapy for Bone Disease: A Review of Current Status

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