Periductal Stromal Hyperplasia and Periductal Stromal Tumor

Rowe, J. Jordi

doi:10.1007/978-3-030-74474-8_3

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…The WHO essential diagnostic criteria for PASH include the presence of bland spindle cell myofibroblasts, an anastomosing network of slit-like channels, and dense acellular collagenous stroma. 12 (A) (B) (C) T A B L E 1 Clinical and pathologic features in patients with vulvar fibroadenoma-a review of the literature (including our case). PASH can simulate a vascular lesion; therefore, immunohistochemistry may sometimes be needed to exclude other differential diagnoses such as a low-grade angiosarcoma, which would be positive for CD31.…”

Section: Discussionmentioning

confidence: 99%

Fibroadenoma of the vulva with pseudoangiomatous stromal hyperplasia: A common neoplasm in uncommon site

Homsi,

Sharma,

Przybycin

et al. 2024

J Cutan Pathol

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Mammary‐type tissue in the vulva was first described in 1872 but has been rarely reported in the literature. This tissue was previously considered as ectopic breast tissue that occurs as a result of incomplete regression of the milk line. Similar to native breast tissue, ectopic mammary tissue is hormone‐sensitive and can develop benign changes, such as fibroadenoma, as well as malignant changes. A more recent theory suggests that these benign and malignant mammary‐type entities arise from mammary‐like anogenital glands, which constitute normal vulvar components. We report a case of a 41‐year‐old woman who presented with a chronic asymptomatic cyst on the left vulva that eventually became uncomfortable, especially on standing. The cyst was located on the labium minus, measuring 1.0 × 0.5 cm, with no identified erythema or other skin abnormalities. Excision of the lesion and subsequent microscopic examination showed a circumscribed mass with a nodular overgrowth of epithelial and stromal components, resembling a mammary fibroadenoma with pseudoangiomatous stromal hyperplasia. We bring to attention this rare diagnosis and the importance of considering it in the presence of a vulvar lesion. The malignant and recurrence potential of mammary‐type tissue necessitates excision with clear margins and close monitoring of these patients.

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Section: Discussionmentioning

confidence: 99%

Fibroadenoma of the vulva with pseudoangiomatous stromal hyperplasia: A common neoplasm in uncommon site

Homsi,

Sharma,

Przybycin

et al. 2024

J Cutan Pathol

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“…Pseudoangiomatous stromal hyperplasia (PASH) can exist independently and is mainly or entirely composed of stromal cells ( 1 ). It is a rare benign lesion of the breast that was first described by Vuitch et al.…”

Section: Introductionmentioning

confidence: 99%

A case report and a literature review of double mammary pseudoangiomatous stromal hyperplasia associated with galactoma during pregnancy

Yu,

Shi,

Gao

et al. 2024

Front. Oncol.

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Pseudoangiomatous stromal hyperplasia (PASH) is a benign interstitial hyperplasia of the breast that usually occurs in premenopausal or perimenopausal women. It is usually characterized by localized lesions or clear boundary masses, and diffuse double breast enlargement is rare. PASH is considered a hormone-dependent disease that is commonly progesterone related. There are no imaging characteristics, and both benign and suspicious malignant signs can be seen. The definitive diagnosis of PASH depends on a pathological diagnosis, and it is necessary to be vigilant in distinguishing between benign and malignant tumors with similar breast histopathology. Here, we report the case of a 23-year-old multipara patient with bilateral diffuse pseudoangiomatous stromal hyperplasia of the breast during pregnancy who presented with macromastia and reviewed the literature to further understand the clinical features, pathological diagnosis, differential diagnosis, treatment and prognosis of pseudoangiomatous stromal hyperplasia of the breast.

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Periductal Stromal Hyperplasia and Periductal Stromal Tumor

Cited by 2 publications

References 5 publications

Fibroadenoma of the vulva with pseudoangiomatous stromal hyperplasia: A common neoplasm in uncommon site

Fibroadenoma of the vulva with pseudoangiomatous stromal hyperplasia: A common neoplasm in uncommon site

A case report and a literature review of double mammary pseudoangiomatous stromal hyperplasia associated with galactoma during pregnancy

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